School of Pharmacy, University of Colorado Health Sciences Center, Denver 80262, USA
Certain compounds such as antitumor quinones, however, can be bioactivated by two electron reduction and in these cases NQO1 serves as an activating enzyme. Because of the high levels of NQO1 in certain tumors, this has led to an interest in designing compounds which can be efficiently bioactivated by NQO1 as antitumor agents.
NQO1 (NAD (P)H dehydrogenase, quinone 1)
Atlas Genet Cytogenet Oncol Haematol. 2004-06-01
Online version: http://atlasgeneticsoncology.org/gene/375/nqo1-(nad-(p)h-dehydrogenase-quinone-1)
2001-12-01 NQO1 (NAD (P)H dehydrogenase, quinone 1) by David Ross