Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 27030
MIM: 604395
HGNC: 7128
Ensembl: ENSG00000119684
Variants:
dbSNP: 27030
ClinVar: 27030
TCGA: ENSG00000119684
COSMIC: MLH3
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Mismatch repair | KEGG | ko03430 |
| Mismatch repair | KEGG | hsa03430 |
| Cell Cycle | REACTOME | R-HSA-1640170 |
| Meiosis | REACTOME | R-HSA-1500620 |
| Meiotic recombination | REACTOME | R-HSA-912446 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 33517345 | 2021 | A loss-of-function variant in DNA mismatch repair gene MLH3 underlies severe oligozoospermia. | 8 |
| 34933735 | 2021 | Exonic sequencing and MLH3 gene expression analysis of breast cancer patients. | 1 |
| 33517345 | 2021 | A loss-of-function variant in DNA mismatch repair gene MLH3 underlies severe oligozoospermia. | 8 |
| 34933735 | 2021 | Exonic sequencing and MLH3 gene expression analysis of breast cancer patients. | 1 |
| 32015124 | 2020 | Human MutLγ, the MLH1-MLH3 heterodimer, is an endonuclease that promotes DNA expansion. | 40 |
| 32814904 | 2020 | Regulation of the MLH1-MLH3 endonuclease in meiosis. | 68 |
| 33453991 | 2020 | Genetic evidence for the involvement of mismatch repair proteins, PMS2 and MLH3, in a late step of homologous recombination. | 16 |
| 32015124 | 2020 | Human MutLγ, the MLH1-MLH3 heterodimer, is an endonuclease that promotes DNA expansion. | 40 |
| 32814904 | 2020 | Regulation of the MLH1-MLH3 endonuclease in meiosis. | 68 |
| 33453991 | 2020 | Genetic evidence for the involvement of mismatch repair proteins, PMS2 and MLH3, in a late step of homologous recombination. | 16 |
| 30573798 | 2019 | Biallelic germline nonsense variant of MLH3 underlies polyposis predisposition. | 25 |
| 31342644 | 2019 | The association of four SNPs in DNA mismatch repair genes with idiopathic male infertility in northwest China. | 3 |
| 30573798 | 2019 | Biallelic germline nonsense variant of MLH3 underlies polyposis predisposition. | 25 |
| 31342644 | 2019 | The association of four SNPs in DNA mismatch repair genes with idiopathic male infertility in northwest China. | 3 |
| 29529236 | 2018 | GAA•TTC repeat expansion in human cells is mediated by mismatch repair complex MutLγ and depends upon the endonuclease domain in MLH3 isoform one. | 24 |
Citation
Dessen P
MLH3 (mutL homolog 3)
Atlas Genet Cytogenet Oncol Haematol. 2003-02-01
Online version: http://atlasgeneticsoncology.org/gene/381/mlh3-(mutl-homolog-3)
