CDC27 (cell division cycle 27)

2003-08-01  

Identity

HGNC
CDC27
LOCATION
17q21.32
LOCUSID
996
ALIAS
ANAPC3,APC3,CDC27Hs,D0S1430E,D17S978E,H-NUC,HNUC,NUC2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 996
MIM: 116946
HGNC: 1728
Ensembl: ENSG00000004897

Variants:

dbSNP: 996
ClinVar: 996
TCGA: ENSG00000004897
COSMIC: CDC27

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000004897ENST00000066544P30260
ENSG00000004897ENST00000526866F6QPS0
ENSG00000004897ENST00000527547G5EA36
ENSG00000004897ENST00000531206P30260
ENSG00000004897ENST00000532893K7EMA6
ENSG00000004897ENST00000533415E9PRZ6
ENSG00000004897ENST00000570740I3L3Y5
ENSG00000004897ENST00000570818I3L2Z8
ENSG00000004897ENST00000571643I3L394
ENSG00000004897ENST00000573502I3L328
ENSG00000004897ENST00000573550I3L3G1
ENSG00000004897ENST00000574304I3L1K3
ENSG00000004897ENST00000575483I3L3H6
ENSG00000004897ENST00000576484I3L225

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cell cycleKEGGko04110
Ubiquitin mediated proteolysisKEGGko04120
Progesterone-mediated oocyte maturationKEGGko04914
Cell cycleKEGGhsa04110
Ubiquitin mediated proteolysisKEGGhsa04120
Progesterone-mediated oocyte maturationKEGGhsa04914
Oocyte meiosisKEGGko04114
Oocyte meiosisKEGGhsa04114
HTLV-I infectionKEGGko05166
HTLV-I infectionKEGGhsa05166
APC/C complexKEGGhsa_M00389
APC/C complexKEGGM00389
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168
Cell CycleREACTOMER-HSA-1640170
Cell Cycle CheckpointsREACTOMER-HSA-69620
Mitotic Spindle CheckpointREACTOMER-HSA-69618
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint componentsREACTOMER-HSA-141405
Inactivation of APC/C via direct inhibition of the APC/C complexREACTOMER-HSA-141430
Cell Cycle, MitoticREACTOMER-HSA-69278
M PhaseREACTOMER-HSA-68886
Mitotic Metaphase and AnaphaseREACTOMER-HSA-2555396
Mitotic AnaphaseREACTOMER-HSA-68882
Separation of Sister ChromatidsREACTOMER-HSA-2467813
Regulation of mitotic cell cycleREACTOMER-HSA-453276
APC/C-mediated degradation of cell cycle proteinsREACTOMER-HSA-174143
Regulation of APC/C activators between G1/S and early anaphaseREACTOMER-HSA-176408
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteinsREACTOMER-HSA-176814
Phosphorylation of the APC/CREACTOMER-HSA-176412
APC/C:Cdc20 mediated degradation of mitotic proteinsREACTOMER-HSA-176409
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpointREACTOMER-HSA-179419
Cdc20:Phospho-APC/C mediated degradation of Cyclin AREACTOMER-HSA-174184
APC-Cdc20 mediated degradation of Nek2AREACTOMER-HSA-179409
APC/C:Cdc20 mediated degradation of Cyclin BREACTOMER-HSA-174048
APC/C:Cdc20 mediated degradation of SecurinREACTOMER-HSA-174154
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphaseREACTOMER-HSA-176407
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1REACTOMER-HSA-174178
Autodegradation of Cdh1 by Cdh1:APC/CREACTOMER-HSA-174084
Cellular responses to stressREACTOMER-HSA-2262752
Cellular SenescenceREACTOMER-HSA-2559583
Senescence-Associated Secretory Phenotype (SASP)REACTOMER-HSA-2559582

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
387319252024Functional and Genetic Analyses Unveil the Implication of CDC27 in Hemifacial Microsomia.0
387319252024Functional and Genetic Analyses Unveil the Implication of CDC27 in Hemifacial Microsomia.0
354189862022A Novel Gene CDC27 Causes SLE and Is Associated With the Disease Activity.2
355616482022Circ_0000775 promotes the migration, invasion and EMT of hepatic carcinoma cells by recruiting IGF2BP2 to stabilize CDC27.2
354189862022A Novel Gene CDC27 Causes SLE and Is Associated With the Disease Activity.2
355616482022Circ_0000775 promotes the migration, invasion and EMT of hepatic carcinoma cells by recruiting IGF2BP2 to stabilize CDC27.2
327107282020Hsa_circ_0044226 knockdown attenuates progression of pulmonary fibrosis by inhibiting CDC27.11
327107282020Hsa_circ_0044226 knockdown attenuates progression of pulmonary fibrosis by inhibiting CDC27.11
303084982018CDC27 Facilitates Gastric Cancer Cell Proliferation, Invasion and Metastasis via Twist-Induced Epithelial-Mesenchymal Transition.18
303084982018CDC27 Facilitates Gastric Cancer Cell Proliferation, Invasion and Metastasis via Twist-Induced Epithelial-Mesenchymal Transition.18
279746732017mir-218-2 promotes glioblastomas growth, invasion and drug resistance by targeting CDC27.10
280044262017Inhibition of Anaphase-Promoting Complex by Silence APC/C(Cdh1) to Enhance Radiosensitivity of Nasopharyngeal Carcinoma Cells.5
282578442017UBE2S associated with OSCC proliferation by promotion of P21 degradation via the ubiquitin-proteasome system.12
279746732017mir-218-2 promotes glioblastomas growth, invasion and drug resistance by targeting CDC27.10
280044262017Inhibition of Anaphase-Promoting Complex by Silence APC/C(Cdh1) to Enhance Radiosensitivity of Nasopharyngeal Carcinoma Cells.5

Citation

Dessen P

CDC27 (cell division cycle 27)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/40007/cdc27-(cell-division-cycle-27)