CDC27 (cell division cycle 27)

2003-08-01  

Identity

HGNC
LOCATION
17q21.32
LOCUSID
ALIAS
ANAPC3,APC3,CDC27Hs,D0S1430E,D17S978E,H-NUC,HNUC,NUC2
FUSION GENES

Other Information

Locus ID:

NCBI: 996
MIM: 116946
HGNC: 1728
Ensembl: ENSG00000004897

Variants:

dbSNP: 996
ClinVar: 996
TCGA: ENSG00000004897
COSMIC: CDC27

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000004897ENST00000066544P30260
ENSG00000004897ENST00000526866F6QPS0
ENSG00000004897ENST00000527547G5EA36
ENSG00000004897ENST00000531206P30260
ENSG00000004897ENST00000532893K7EMA6
ENSG00000004897ENST00000533415E9PRZ6
ENSG00000004897ENST00000570740I3L3Y5
ENSG00000004897ENST00000570818I3L2Z8
ENSG00000004897ENST00000571643I3L394
ENSG00000004897ENST00000573502I3L328
ENSG00000004897ENST00000573550I3L3G1
ENSG00000004897ENST00000574304I3L1K3
ENSG00000004897ENST00000575483I3L3H6
ENSG00000004897ENST00000576484I3L225

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50

Pathways

PathwaySourceExternal ID
Cell cycleKEGGko04110
Ubiquitin mediated proteolysisKEGGko04120
Progesterone-mediated oocyte maturationKEGGko04914
Cell cycleKEGGhsa04110
Ubiquitin mediated proteolysisKEGGhsa04120
Progesterone-mediated oocyte maturationKEGGhsa04914
Oocyte meiosisKEGGko04114
Oocyte meiosisKEGGhsa04114
HTLV-I infectionKEGGko05166
HTLV-I infectionKEGGhsa05166
APC/C complexKEGGhsa_M00389
APC/C complexKEGGM00389
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168
Cell CycleREACTOMER-HSA-1640170
Cell Cycle CheckpointsREACTOMER-HSA-69620
Mitotic Spindle CheckpointREACTOMER-HSA-69618
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint componentsREACTOMER-HSA-141405
Inactivation of APC/C via direct inhibition of the APC/C complexREACTOMER-HSA-141430
Cell Cycle, MitoticREACTOMER-HSA-69278
M PhaseREACTOMER-HSA-68886
Mitotic Metaphase and AnaphaseREACTOMER-HSA-2555396
Mitotic AnaphaseREACTOMER-HSA-68882
Separation of Sister ChromatidsREACTOMER-HSA-2467813
Regulation of mitotic cell cycleREACTOMER-HSA-453276
APC/C-mediated degradation of cell cycle proteinsREACTOMER-HSA-174143
Regulation of APC/C activators between G1/S and early anaphaseREACTOMER-HSA-176408
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteinsREACTOMER-HSA-176814
Phosphorylation of the APC/CREACTOMER-HSA-176412
APC/C:Cdc20 mediated degradation of mitotic proteinsREACTOMER-HSA-176409
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpointREACTOMER-HSA-179419
Cdc20:Phospho-APC/C mediated degradation of Cyclin AREACTOMER-HSA-174184
APC-Cdc20 mediated degradation of Nek2AREACTOMER-HSA-179409
APC/C:Cdc20 mediated degradation of Cyclin BREACTOMER-HSA-174048
APC/C:Cdc20 mediated degradation of SecurinREACTOMER-HSA-174154
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphaseREACTOMER-HSA-176407
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1REACTOMER-HSA-174178
Autodegradation of Cdh1 by Cdh1:APC/CREACTOMER-HSA-174084
Cellular responses to stressREACTOMER-HSA-2262752
Cellular SenescenceREACTOMER-HSA-2559583
Senescence-Associated Secretory Phenotype (SASP)REACTOMER-HSA-2559582

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
213363062011How APC/C-Cdc20 changes its substrate specificity in mitosis.62
128534862003Early mitotic degradation of the homeoprotein HOXC10 is potentially linked to cell cycle progression.34
230784092013Recombinant expression, reconstitution and structure of human anaphase-promoting complex (APC/C).28
178271482007The DNA damage response mediator MDC1 directly interacts with the anaphase-promoting complex/cyclosome.21
254902582015Structure of an APC3-APC16 complex: insights into assembly of the anaphase-promoting complex/cyclosome.17
124299482002The dephosphorylated form of the anaphase-promoting complex protein Cdc27/Apc3 concentrates on kinetochores and chromosome arms in mitosis.16
205089832011Centrosome-related genes, genetic variation, and risk of breast cancer.16
259436332015MiR-27a modulates radiosensitivity of triple-negative breast cancer (TNBC) cells by targeting CDC27.14
212090742011Phosphorylation of the anaphase-promoting complex/Cdc27 is involved in TGF-beta signaling.8
221398412012Molecular basis for the association of microcephalin (MCPH1) protein with the cell division cycle protein 27 (Cdc27) subunit of the anaphase-promoting complex.8

Citation

Dessen P

CDC27 (cell division cycle 27)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/40007/cdc27-(cell-division-cycle-27)