CDK11B (cyclin dependent kinase 11B)

2003-06-01  

Identity

HGNC
CDK11B
LOCATION
1p36.33
LOCUSID
984
ALIAS
CDC2L1,CDK11,CDK11-p110,CDK11-p46,CDK11-p58,CLK-1,PITSLREA,PK58,p58,p58CDC2L1,p58CLK-1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 984
MIM: 176873
HGNC: 1729
Ensembl: ENSG00000248333

Variants:

dbSNP: 984
ClinVar: 984
TCGA: ENSG00000248333
COSMIC: CDK11B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000248333ENST00000340677P21127
ENSG00000248333ENST00000341832P21127
ENSG00000248333ENST00000407249P21127
ENSG00000248333ENST00000611150A0A087X1I0
ENSG00000248333ENST00000615951A0A087WYI9
ENSG00000248333ENST00000626918A0A0D9SEI3
ENSG00000248333ENST00000629289A0A0D9SER5
ENSG00000248333ENST00000629312A0A0D9SEN2

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G2-G2/M phasesREACTOMER-HSA-453274
G2/M TransitionREACTOMER-HSA-69275
Centrosome maturationREACTOMER-HSA-380287
Recruitment of mitotic centrosome proteins and complexesREACTOMER-HSA-380270

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
380196132024CDK11 facilitates centromeric transcription to maintain centromeric cohesion during mitosis.2
380196132024CDK11 facilitates centromeric transcription to maintain centromeric cohesion during mitosis.2
368557762023Therapeutic potential of CDK11 in cancer.2
369887712023CDK10, CDK11, FOXO1, and FOXO3 Gene Expression in Alzheimer's Disease Encephalic Samples.1
368557762023Therapeutic potential of CDK11 in cancer.2
369887712023CDK10, CDK11, FOXO1, and FOXO3 Gene Expression in Alzheimer's Disease Encephalic Samples.1
320304512020A cyclin-dependent kinase, CDK11/p58, represses cap-dependent translation during mitosis.4
323670682020CDK11 is required for transcription of replication-dependent histone genes.19
325877722020CDK11 negatively regulates Wnt/β-catenin signaling in the endosomal compartment by affecting microtubule stability.3
320304512020A cyclin-dependent kinase, CDK11/p58, represses cap-dependent translation during mitosis.4
323670682020CDK11 is required for transcription of replication-dependent histone genes.19
325877722020CDK11 negatively regulates Wnt/β-catenin signaling in the endosomal compartment by affecting microtubule stability.3
307227252019CDK11(p110) plays a critical role in the tumorigenicity of esophageal squamous cell carcinoma cells and is a potential drug target.9
316107982019Transcriptional activation of CBFβ by CDK11(p110) is necessary to promote osteosarcoma cell proliferation.4
307227252019CDK11(p110) plays a critical role in the tumorigenicity of esophageal squamous cell carcinoma cells and is a potential drug target.9

Citation

Dessen P

CDK11B (cyclin dependent kinase 11B)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/40008/cdk11b-(cyclin-dependent-kinase-11b)