CDK13 (cyclin dependent kinase 13)

2003-11-01  

Identity

HGNC
LOCATION
7p14.1
LOCUSID
ALIAS
CDC2L,CDC2L5,CHDFIDD,CHED,hCDK13
FUSION GENES

Other Information

Locus ID:

NCBI: 8621
MIM: 603309
HGNC: 1733
Ensembl: ENSG00000065883

Variants:

dbSNP: 8621
ClinVar: 8621
TCGA: ENSG00000065883
COSMIC: CDK13

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000065883ENST00000181839Q14004
ENSG00000065883ENST00000181839A0A024RA85
ENSG00000065883ENST00000340829Q14004
ENSG00000065883ENST00000340829A0A024RA66
ENSG00000065883ENST00000484589A0A2R8YD28
ENSG00000065883ENST00000611390A0A087X209
ENSG00000065883ENST00000613626Q9BVE2
ENSG00000065883ENST00000642592A0A2R8YEB7
ENSG00000065883ENST00000642626A0A2R8YCQ1
ENSG00000065883ENST00000643859A0A2R8Y7W5
ENSG00000065883ENST00000643868A0A2R8YFE7
ENSG00000065883ENST00000643915A0A2R8YF61
ENSG00000065883ENST00000645470A0A2R8Y644
ENSG00000065883ENST00000646039A0A2R8Y4Z0
ENSG00000065883ENST00000646437A0A2R8Y7Y0

Expression (GTEx)

0
5
10
15
20
25
30
35

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
TP53 Regulates Transcription of DNA Repair GenesREACTOMER-HSA-6796648
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
274799072016Distinct genetic architectures for syndromic and nonsyndromic congenital heart defects identified by exome sequencing.73
255614692015Characterization of human cyclin-dependent kinase 12 (CDK12) and CDK13 complexes in C-terminal domain phosphorylation, gene transcription, and RNA processing.48
167218272006CDC2L5, a Cdk-like kinase with RS domain, interacts with the ASF/SF2-associated protein p32 and affects splicing in vivo.28
229128322012Frequent amplification of CENPF, GMNN and CDK13 genes in hepatocellular carcinomas.25
225470582012Cyclin K-containing kinase complexes maintain self-renewal in murine embryonic stem cells.24
252167002015Protein deep sequencing applied to biobank samples from patients with pancreatic cancer.20
288070082017Phenotypic and molecular characterisation of CDK13-related congenital heart defects, dysmorphic facial features and intellectual developmental disorders.10
303190072019Human CDK12 and CDK13, multi-tasking CTD kinases for the new millenium.9
290214032018Heterozygous mutations affecting the protein kinase domain of CDK13 cause a syndromic form of developmental delay and intellectual disability.8
268864222016CDK13, a Kinase Involved in Pre-mRNA Splicing, Is a Component of the Perinucleolar Compartment.4

Citation

Dessen P

CDK13 (cyclin dependent kinase 13)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/40009/cdk13-(cyclin-dependent-kinase-13)