CDK8 (cyclin dependent kinase 8)

2003-08-01 Affiliation

Identity

HGNC

CDK8

LOCATION

13q12.13

LOCUSID

1024

ALIAS

IDDHBA,K35

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 1024
MIM: 603184
HGNC: 1779
Ensembl: ENSG00000132964

Variants:

dbSNP: 1024
ClinVar: 1024
TCGA: ENSG00000132964
COSMIC: CDK8

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000132964	ENST00000381527	P49336
ENSG00000132964	ENST00000465820	A0A0D9SFZ2
ENSG00000132964	ENST00000536792	F5H6D4
ENSG00000132964	ENST00000625988	A0A0D9SEP3

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Disease	REACTOME	R-HSA-1643685
Diseases of signal transduction	REACTOME	R-HSA-5663202
Signaling by NOTCH1 in Cancer	REACTOME	R-HSA-2644603
Signaling by NOTCH1 PEST Domain Mutants in Cancer	REACTOME	R-HSA-2644602
Constitutive Signaling by NOTCH1 PEST Domain Mutants	REACTOME	R-HSA-2644606
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	REACTOME	R-HSA-2894858
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	REACTOME	R-HSA-2894862
Signal Transduction	REACTOME	R-HSA-162582
Signaling by TGF-beta Receptor Complex	REACTOME	R-HSA-170834
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	REACTOME	R-HSA-2173793
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	REACTOME	R-HSA-2173796
Signaling by NOTCH	REACTOME	R-HSA-157118
Signaling by NOTCH1	REACTOME	R-HSA-1980143
NOTCH1 Intracellular Domain Regulates Transcription	REACTOME	R-HSA-2122947
Gene Expression	REACTOME	R-HSA-74160
Generic Transcription Pathway	REACTOME	R-HSA-212436
Metabolism	REACTOME	R-HSA-1430728
Metabolism of lipids and lipoproteins	REACTOME	R-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolism	REACTOME	R-HSA-535734
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)	REACTOME	R-HSA-400206
PPARA activates gene expression	REACTOME	R-HSA-1989781
Developmental Biology	REACTOME	R-HSA-1266738
Transcriptional regulation of white adipocyte differentiation	REACTOME	R-HSA-381340

References

Pubmed ID	Year	Title	Citations
18794900	2008	CDK8 is a colorectal cancer oncogene that regulates beta-catenin activity.	255
20098423	2010	CDK8 is a positive regulator of transcriptional elongation within the serum response network.	162
21179167	2010	The histone variant macroH2A suppresses melanoma progression through regulation of CDK8.	145
19240132	2009	The human CDK8 subcomplex is a molecular switch that controls Mediator coactivator function.	142
23746844	2013	HIF1A employs CDK8-mediator to stimulate RNAPII elongation in response to hypoxia.	124
17612495	2007	CDK8 is a stimulus-specific positive coregulator of p53 target genes.	121
18794899	2008	E2F1 represses beta-catenin transcription and is antagonized by both pRB and CDK8.	121
26416749	2015	Mediator kinase inhibition further activates super-enhancer-associated genes in AML.	103
19047373	2009	The human CDK8 subcomplex is a histone kinase that requires Med12 for activity and can function independently of mediator.	83
23352233	2013	CDK8 kinase phosphorylates transcription factor STAT1 to selectively regulate the interferon response.	82

Citation

Dessen P

CDK8 (cyclin dependent kinase 8)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/40036/cdk8-(cyclin-dependent-kinase-8)