CDKN2D (cyclin dependent kinase inhibitor 2D)

2003-02-01  

Identity

HGNC
LOCATION
19p13.2
LOCUSID
ALIAS
INK4D,p19,p19-INK4D
FUSION GENES

Other Information

Locus ID:

NCBI: 1032
MIM: 600927
HGNC: 1790
Ensembl: ENSG00000129355

Variants:

dbSNP: 1032
ClinVar: 1032
TCGA: ENSG00000129355
COSMIC: CDKN2D

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000129355ENST00000335766P55273
ENSG00000129355ENST00000335766A0A024R796
ENSG00000129355ENST00000393599P55273
ENSG00000129355ENST00000393599A0A024R796

Expression (GTEx)

0
50
100
150
200
250

Pathways

PathwaySourceExternal ID
Cell cycleKEGGko04110
Cell cycleKEGGhsa04110
FoxO signaling pathwayKEGGhsa04068
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G1-G1/S phasesREACTOMER-HSA-453279
G1 PhaseREACTOMER-HSA-69236
Cyclin D associated events in G1REACTOMER-HSA-69231
Cellular responses to stressREACTOMER-HSA-2262752
Cellular SenescenceREACTOMER-HSA-2559583
Oncogene Induced SenescenceREACTOMER-HSA-2559585
Oxidative Stress Induced SenescenceREACTOMER-HSA-2559580
Senescence-Associated Secretory Phenotype (SASP)REACTOMER-HSA-2559582

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
191415852009Rare germline mutations in cyclin-dependent kinase inhibitor genes in multiple endocrine neoplasia type 1 and related states.70
174094092007Tagging single nucleotide polymorphisms in cell cycle control genes and susceptibility to invasive epithelial ovarian cancer.47
151078222004Histone deacetylase inhibitors activate INK4d gene through Sp1 site in its promoter.27
194307072009Identification of aberrant cell cycle regulation in Epstein-Barr virus-associated nasopharyngeal carcinoma by cDNA microarray and gene set enrichment analysis.26
181742432008Association of single-nucleotide polymorphisms in the cell cycle genes with breast cancer in the British population.24
191245062009Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer.22
117860242002Protein folding and stability of human CDK inhibitor p19(INK4d).20
126981962003Antitumour effect of cyclin-dependent kinase inhibitors (p16(INK4A), p18(INK4C), p19(INK4D), p21(WAF1/CIP1) and p27(KIP1)) on malignant glioma cells.17
185078372008Effects of common germline genetic variation in cell cycle control genes on breast cancer survival: results from a population-based cohort.17
197386112009Cell cycle genes and ovarian cancer susceptibility: a tagSNP analysis.17

Citation

Dessen P

CDKN2D (cyclin dependent kinase inhibitor 2D)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40038/cdkn2d-(cyclin-dependent-kinase-inhibitor-2d)