CEACAM3 (CEA cell adhesion molecule 3)

2003-06-01  

Identity

HGNC
LOCATION
19q13.2
LOCUSID
ALIAS
CD66D,CEA,CGM1,W264,W282

Other Information

Locus ID:

NCBI: 1084
MIM: 609142
HGNC: 1815
Ensembl: ENSG00000170956

Variants:

dbSNP: 1084
ClinVar: 1084
TCGA: ENSG00000170956
COSMIC: CEACAM3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000170956ENST00000344550P40198
ENSG00000170956ENST00000357396P40198
ENSG00000170956ENST00000415495P40198
ENSG00000170956ENST00000415495B7Z5B4
ENSG00000170956ENST00000596544M0QXR5
ENSG00000170956ENST00000630848P40198

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
HemostasisREACTOMER-HSA-109582
Cell surface interactions at the vascular wallREACTOMER-HSA-202733
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
147071132004Granulocyte CEACAM3 is a phagocytic receptor of the innate immune system that mediates recognition and elimination of human-specific pathogens.59
277487682016Helicobacter pylori adhesin HopQ engages in a virulence-enhancing interaction with human CEACAMs.52
277487562016Helicobacter pylori exploits human CEACAMs via HopQ for adherence and translocation of CagA.42
220647172012Defining the roles of human carcinoembryonic antigen-related cellular adhesion molecules during neutrophil responses to Neisseria gonorrhoeae.36
175068202007The specific innate immune receptor CEACAM3 triggers neutrophil bactericidal activities via a Syk kinase-dependent pathway.31
125712362003Phosphatidylinositol 3-kinases in carcinoembryonic antigen-related cellular adhesion molecule-mediated internalization of Neisseria gonorrhoeae.22
190772072008Interdependency of CEACAM-1, -3, -6, and -8 induced human neutrophil adhesion to endothelial cells.16
224699502012HemITAM signaling by CEACAM3, a human granulocyte receptor recognizing bacterial pathogens.14
212169682011Phosphatidylinositol 3'-kinase activity is critical for initiating the oxidative burst and bacterial destruction during CEACAM3-mediated phagocytosis.13

Citation

Dessen P

CEACAM3 (CEA cell adhesion molecule 3)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/40045/ceacam3-(cea-cell-adhesion-molecule-3)