CEACAM8 (CEA cell adhesion molecule 8)

2003-06-01  

Identity

HGNC
CEACAM8
LOCATION
19q13.2
LOCUSID
1088
ALIAS
CD66b,CD67,CGM6,NCA-95

Other Information

Locus ID:

NCBI: 1088
MIM: 615747
HGNC: 1820
Ensembl: ENSG00000124469

Variants:

dbSNP: 1088
ClinVar: 1088
TCGA: ENSG00000124469
COSMIC: CEACAM8

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000124469ENST00000244336P31997
ENSG00000124469ENST00000244336Q0Z7S6
ENSG00000124469ENST00000599005M0R1X3

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
HemostasisREACTOMER-HSA-109582
Cell surface interactions at the vascular wallREACTOMER-HSA-202733
Extracellular matrix organizationREACTOMER-HSA-1474244
Fibronectin matrix formationREACTOMER-HSA-1566977
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
180563922007CD66b regulates adhesion and activation of human eosinophils.32
247433042014Soluble CEACAM8 interacts with CEACAM1 inhibiting TLR2-triggered immune responses.17
190772072008Interdependency of CEACAM-1, -3, -6, and -8 induced human neutrophil adhesion to endothelial cells.16
264834852015Diverse oligomeric states of CEACAM IgV domains.11
179097992008High expression of CEACAM6 and CEACAM8 mRNA in acute lymphoblastic leukemias.8
214706772011High expression of carcinoembryonic antigen-related cell adhesion molecule (CEACAM) 6 and 8 in primary myelofibrosis.4
236860792013Fasting glucose level modulates cell surface expression of CD11b and CD66b in granulocytes and monocytes of patients with type 2 diabetes.4
278634782016Prognostic value of CD66b positive tumor-infiltrating neutrophils in testicular germ cell tumor.2
275798962016A 7-Gene Signature Depicts the Biochemical Profile of Early Prefibrotic Myelofibrosis.1
261766692015CD66b Overexpression and Loss of C5a Receptors as Surface Markers for Staphylococcus aureus-Induced Neutrophil Dysfunction.0

Citation

Dessen P

CEACAM8 (CEA cell adhesion molecule 8)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/40049/ceacam8-(cea-cell-adhesion-molecule-8)