CEBPB (CCAAT enhancer binding protein beta)

2003-02-01  

Identity

HGNC
LOCATION
20q13.13
LOCUSID
ALIAS
C/EBP-beta,IL6DBP,NF-IL6,TCF5
FUSION GENES

Other Information

Locus ID:

NCBI: 1051
MIM: 189965
HGNC: 1834
Ensembl: ENSG00000172216

Variants:

dbSNP: 1051
ClinVar: 1051
TCGA: ENSG00000172216
COSMIC: CEBPB

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000172216ENST00000303004P17676

Expression (GTEx)

0
50
100
150
200
250
300
350
400

Pathways

PathwaySourceExternal ID
TuberculosisKEGGko05152
TuberculosisKEGGhsa05152
Transcriptional misregulation in cancerKEGGko05202
Transcriptional misregulation in cancerKEGGhsa05202
TNF signaling pathwayKEGGhsa04668
TNF signaling pathwayKEGGko04668
Developmental BiologyREACTOMER-HSA-1266738
Transcriptional regulation of white adipocyte differentiationREACTOMER-HSA-381340
Cellular responses to stressREACTOMER-HSA-2262752
Cellular SenescenceREACTOMER-HSA-2559583
Senescence-Associated Secretory Phenotype (SASP)REACTOMER-HSA-2559582
IL-17 signaling pathwayKEGGko04657
IL-17 signaling pathwayKEGGhsa04657

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
200329752010The transcriptional network for mesenchymal transformation of brain tumours.511
19340611991A liver-enriched transcriptional activator protein, LAP, and a transcriptional inhibitory protein, LIP, are translated from the same mRNA.341
196414922009Initiation of myoblast to brown fat switch by a PRDM16-C/EBP-beta transcriptional complex.270
109219062000Translational control of C/EBPalpha and C/EBPbeta isoform expression.191
206054852010Tumor-induced tolerance and immune suppression depend on the C/EBPbeta transcription factor.149
169596122006C/EBPbeta at the core of the TGFbeta cytostatic response and its evasion in metastatic breast cancer cells.115
153855332004Amino acid deprivation induces the transcription rate of the human asparagine synthetase gene through a timed program of expression and promoter binding of nutrient-responsive basic region/leucine zipper transcription factors as well as localized histone acetylation.87
117566622002CCAAT/enhancer binding protein-beta is a mediator of keratinocyte survival and skin tumorigenesis involving oncogenic Ras signaling.84
147593692004Ras induces mediator complex exchange on C/EBP beta.79
179213242007IL-17 stimulates MMP-1 expression in primary human cardiac fibroblasts via p38 MAPK- and ERK1/2-dependent C/EBP-beta , NF-kappaB, and AP-1 activation.79

Citation

Dessen P

CEBPB (CCAAT enhancer binding protein beta)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40051/cebpb-(ccaat-enhancer-binding-protein-beta)