CHAF1B (chromatin assembly factor 1 subunit B)

2003-12-01  

Identity

HGNC
LOCATION
21q22.12
LOCUSID
ALIAS
CAF-1,CAF-IP60,CAF1,CAF1A,CAF1P60,MPHOSPH7,MPP7

Other Information

Locus ID:

NCBI: 8208
MIM: 601245
HGNC: 1911
Ensembl: ENSG00000159259

Variants:

dbSNP: 8208
ClinVar: 8208
TCGA: ENSG00000159259
COSMIC: CHAF1B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000159259ENST00000314103Q13112

Expression (GTEx)

0
5
10
15

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
118976622002Human Asf1 and CAF-1 interact and synergize in a repair-coupled nucleosome assembly pathway.111
194984642009The HP1alpha-CAF1-SetDB1-containing complex provides H3K9me1 for Suv39-mediated K9me3 in pericentric heterochromatin.86
169809722006Structure of a human ASF1a-HIRA complex and insights into specificity of histone chaperone complex assembly.76
150240742004Silencing of chromatin assembly factor 1 in human cells leads to cell death and loss of chromatin assembly during DNA synthesis.46
210836012010Clinical significance and prognostic value of chromatin assembly factor-1 overexpression in human solid tumours.21
201786512010Overexpression of Chromatin Assembly Factor-1/p60 helps to predict the prognosis of melanoma patients.17
193094892009Overexpression of chromatin assembly factor-1 (CAF-1) p60 is predictive of adverse behaviour of prostatic cancer.15
240399142013Prognostic significance of EDN/RB, HJURP, p60/CAF-1 and PDLI4, four new markers in high-grade gliomas.15
211099522011The proliferation marker Chromatin Assembly Factor-1 is of clinical value in predicting the biological behaviour of salivary gland tumours.10
231098372012Tissue microarray-based evaluation of Chromatin Assembly Factor-1 (CAF-1)/p60 as tumour prognostic marker.7

Citation

Dessen P

CHAF1B (chromatin assembly factor 1 subunit B)

Atlas Genet Cytogenet Oncol Haematol. 2003-12-01

Online version: http://atlasgeneticsoncology.org/gene/40068/chaf1b-(chromatin-assembly-factor-1-subunit-b)