RCC1 (regulator of chromosome condensation 1)

2003-11-01  

Identity

HGNC
RCC1
LOCATION
1p35.3
LOCUSID
1104
ALIAS
CHC1,RCC1-I,SNHG3-RCC1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 1104
MIM: 179710
HGNC: 1913
Ensembl: ENSG00000180198

Variants:

dbSNP: 1104
ClinVar: 1104
TCGA: ENSG00000180198
COSMIC: RCC1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000180198ENST00000373831P18754
ENSG00000180198ENST00000373831A0A0S2Z404
ENSG00000180198ENST00000373832P18754
ENSG00000180198ENST00000373832Q5T081
ENSG00000180198ENST00000373833P18754
ENSG00000180198ENST00000373833Q5T081
ENSG00000180198ENST00000398958P18754
ENSG00000180198ENST00000398958Q5T081
ENSG00000180198ENST00000411533C9JW69
ENSG00000180198ENST00000419074C9JMJ4
ENSG00000180198ENST00000427469C9JRH2
ENSG00000180198ENST00000430407C9JQZ4
ENSG00000180198ENST00000434290C9J3R0
ENSG00000180198ENST00000486790M0R1Q8
ENSG00000180198ENST00000649185P18754
ENSG00000180198ENST00000649185A0A0S2Z404

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
DiseaseREACTOMER-HSA-1643685
Infectious diseaseREACTOMER-HSA-5663205
HIV InfectionREACTOMER-HSA-162906
HIV Life CycleREACTOMER-HSA-162587
Late Phase of HIV Life CycleREACTOMER-HSA-162599
Rev-mediated nuclear export of HIV RNAREACTOMER-HSA-165054
Host Interactions of HIV factorsREACTOMER-HSA-162909
Interactions of Rev with host cellular proteinsREACTOMER-HSA-177243
Nuclear import of Rev proteinREACTOMER-HSA-180746

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
385613752024Targeting RCC1 to block the human soft-tissue sarcoma by disrupting nucleo-cytoplasmic trafficking of Skp2.0
385613752024Targeting RCC1 to block the human soft-tissue sarcoma by disrupting nucleo-cytoplasmic trafficking of Skp2.0
377470772023RCC1 functions as a tumor facilitator in clear cell renal cell carcinoma by dysregulating cell cycle, apoptosis, and EZH2 stability.1
380870572023A novel DNA methylation signature revealed GDF6 and RCC1 as potential prognostic biomarkers correlated with cell proliferation in clear cell renal cell carcinoma.0
377470772023RCC1 functions as a tumor facilitator in clear cell renal cell carcinoma by dysregulating cell cycle, apoptosis, and EZH2 stability.1
380870572023A novel DNA methylation signature revealed GDF6 and RCC1 as potential prognostic biomarkers correlated with cell proliferation in clear cell renal cell carcinoma.0
335397872021PRMT6 methylation of RCC1 regulates mitosis, tumorigenicity, and radiation response of glioblastoma stem cells.44
336304172021Down-regulation of RCC1 sensitizes immunotherapy by up-regulating PD-L1 via p27(kip1) /CDK4 axis in non-small cell lung cancer.10
343566192021Phosphorylation of RCC1 on Serine 11 Facilitates G1/S Transition in HPV E7-Expressing Cells.3
349248212021RCC1 Expression as a Prognostic Marker in Colorectal Liver Oligometastases.4
335397872021PRMT6 methylation of RCC1 regulates mitosis, tumorigenicity, and radiation response of glioblastoma stem cells.44
336304172021Down-regulation of RCC1 sensitizes immunotherapy by up-regulating PD-L1 via p27(kip1) /CDK4 axis in non-small cell lung cancer.10
343566192021Phosphorylation of RCC1 on Serine 11 Facilitates G1/S Transition in HPV E7-Expressing Cells.3
349248212021RCC1 Expression as a Prognostic Marker in Colorectal Liver Oligometastases.4
325948332020RanBP1 controls the Ran pathway in mammalian cells through regulation of mitotic RCC1 dynamics.11

Citation

Dessen P

RCC1 (regulator of chromosome condensation 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/40069/rcc1-(regulator-of-chromosome-condensation-1)