CHI3L1 (chitinase 3 like 1)

2003-02-01  

Identity

HGNC
LOCATION
1q32.1
LOCUSID
ALIAS
ASRT7,CGP-39,GP-39,GP39,HC-gp39,HCGP-3P,YK-40,YKL-40,YKL40,YYL-40,hCGP-39
FUSION GENES

Other Information

Locus ID:

NCBI: 1116
MIM: 601525
HGNC: 1932
Ensembl: ENSG00000133048

Variants:

dbSNP: 1116
ClinVar: 1116
TCGA: ENSG00000133048
COSMIC: CHI3L1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000133048ENST00000255409P36222
ENSG00000133048ENST00000255409A0A024R969
ENSG00000133048ENST00000404436H0Y3U8

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Neutrophil degranulationREACTOMER-HSA-6798695

References

Pubmed IDYearTitleCitations
184037592008Effect of variation in CHI3L1 on serum YKL-40 level, risk of asthma, and lung function.182
184037592008Effect of variation in CHI3L1 on serum YKL-40 level, risk of asthma, and lung function.182
197677682009YKL-40, a secreted glycoprotein, promotes tumor angiogenesis.103
120718452002The chitinase 3-like protein human cartilage glycoprotein 39 (HC-gp39) stimulates proliferation of human connective-tissue cells and activates both extracellular signal-regulated kinase- and protein kinase B-mediated signalling pathways.86
188021212008YKL-40 is elevated in patients with chronic obstructive pulmonary disease and activates alveolar macrophages.79
213858702011Role of YKL-40 in the angiogenesis, radioresistance, and progression of glioblastoma.77
168186902006Prognostic associations of activated mitogen-activated protein kinase and Akt pathways in glioblastoma.63
158672312005YKL-40 expression is associated with poorer response to radiation and shorter overall survival in glioblastoma.61
205407362010In vivo CHI3L1 (YKL-40) expression in astrocytes in acute and chronic neurological diseases.61
202371292010Cerebrospinal fluid chitinase 3-like 1 levels are associated with conversion to multiple sclerosis.57

Citation

Dessen P

CHI3L1 (chitinase 3 like 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40075/chi3l1-(chitinase-3-like-1)