LEF1 (lymphoid enhancer binding factor 1)

2003-02-01  

Identity

HGNC
LOCATION
4q25
LOCUSID
ALIAS
LEF-1,TCF10,TCF1ALPHA,TCF7L3
FUSION GENES

Other Information

Locus ID:

NCBI: 51176
MIM: 153245
HGNC: 6551
Ensembl: ENSG00000138795

Variants:

dbSNP: 51176
ClinVar: 51176
TCGA: ENSG00000138795
COSMIC: LEF1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000138795ENST00000265165Q9UJU2
ENSG00000138795ENST00000265165A0A024RDI7
ENSG00000138795ENST00000379951Q9UJU2
ENSG00000138795ENST00000438313Q9UJU2
ENSG00000138795ENST00000504950D6RID7
ENSG00000138795ENST00000506680Q9UJU2
ENSG00000138795ENST00000510624Q9UJU2
ENSG00000138795ENST00000512172D6RIV1
ENSG00000138795ENST00000515500D6RAB1

Expression (GTEx)

0
5
10
15
20
25

Pathways

PathwaySourceExternal ID
Wnt signaling pathwayKEGGko04310
Adherens junctionKEGGko04520
MelanogenesisKEGGko04916
Colorectal cancerKEGGko05210
Endometrial cancerKEGGko05213
Prostate cancerKEGGko05215
Thyroid cancerKEGGko05216
Basal cell carcinomaKEGGko05217
Acute myeloid leukemiaKEGGko05221
Wnt signaling pathwayKEGGhsa04310
Adherens junctionKEGGhsa04520
MelanogenesisKEGGhsa04916
Pathways in cancerKEGGhsa05200
Colorectal cancerKEGGhsa05210
Endometrial cancerKEGGhsa05213
Prostate cancerKEGGhsa05215
Thyroid cancerKEGGhsa05216
Basal cell carcinomaKEGGhsa05217
Acute myeloid leukemiaKEGGhsa05221
Arrhythmogenic right ventricular cardiomyopathy (ARVC)KEGGko05412
Arrhythmogenic right ventricular cardiomyopathy (ARVC)KEGGhsa05412
Hippo signaling pathwayKEGGhsa04390
Hippo signaling pathwayKEGGko04390
Wnt signalingKEGGhsa_M00677
Wnt signalingKEGGM00677
Signal TransductionREACTOMER-HSA-162582
Signaling by WntREACTOMER-HSA-195721
Degradation of beta-catenin by the destruction complexREACTOMER-HSA-195253
Repression of WNT target genesREACTOMER-HSA-4641265
TCF dependent signaling in response to WNTREACTOMER-HSA-201681
Formation of the beta-catenin:TCF transactivating complexREACTOMER-HSA-201722
Binding of TCF/LEF:CTNNB1 to target gene promotersREACTOMER-HSA-4411364
Deactivation of the beta-catenin transactivating complexREACTOMER-HSA-3769402
Beta-catenin independent WNT signalingREACTOMER-HSA-3858494
Ca2+ pathwayREACTOMER-HSA-4086398
Breast cancerKEGGko05224
Breast cancerKEGGhsa05224

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
381694252024Downregulation of TCF7 and LEF1 is a key determinant of tumor-infiltrating regulatory T-cell function.0
381694252024Downregulation of TCF7 and LEF1 is a key determinant of tumor-infiltrating regulatory T-cell function.0
364847362023LEF1 Drives a Central Memory Program and Supports Antitumor Activity of Natural Killer T Cells.5
366477952023Onychomatricoma: a clinicopathological, immunohistochemical, and molecular study of 10 cases highlighting recurrent RB1 deletion and the potential diagnostic value of LEF-1.1
368773082023Altered levels of lymphocyte enhancer-binding factor-1 modulates the pigmentation in acral and non-acral lesions of non-segmental vitiligo patients: a follow-up-based study in North India.1
369970012023Proteogenomic Profiling of High-Grade B-Cell Lymphoma With 11q Aberrations and Burkitt Lymphoma Reveals Lymphoid Enhancer Binding Factor 1 as a Novel Biomarker.0
371063792023The β-catenin-LINC00183-miR-371b-5p-Smad2/LEF1 axis promotes adult T-cell lymphoblastic lymphoma progression and chemoresistance.7
374622052023PRAME and LEF1 in Combined Deep Penetrating Nevus and Combined Blue Nevus: Utility and Pitfalls.0
375237932023PD1 is transcriptionally regulated by LEF1 in mature T cells.1
375304852023Constant small-cell changes and variable LEF1 expression in DUSP22-rearranged primary cutaneous anaplastic large-cell lymphoma: Analysis of the repeated biopsies of three patients.0
375533622023Carcinogenesis promotion in oral squamous cell carcinoma: KDM4A complex-mediated gene transcriptional suppression by LEF1.1
379610302023LEF1 isoforms regulate cellular senescence and aging.2
381132732023A distinct isoform of lymphoid enhancer binding factor 1 (LEF1) epigenetically restricts EBV reactivation to maintain viral latency.1
364847362023LEF1 Drives a Central Memory Program and Supports Antitumor Activity of Natural Killer T Cells.5
366477952023Onychomatricoma: a clinicopathological, immunohistochemical, and molecular study of 10 cases highlighting recurrent RB1 deletion and the potential diagnostic value of LEF-1.1

Citation

Dessen P

LEF1 (lymphoid enhancer binding factor 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/401/lef1-(lymphoid-enhancer-binding-factor-1)