CNOT2 (CCR4-NOT transcription complex subunit 2)

2003-12-01  

Identity

HGNC
CNOT2
LOCATION
12q15
LOCUSID
4848
ALIAS
CDC36,HSPC131,IDNADFS,NOT2,NOT2H
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 4848
MIM: 604909
HGNC: 7878
Ensembl: ENSG00000111596

Variants:

dbSNP: 4848
ClinVar: 4848
TCGA: ENSG00000111596
COSMIC: CNOT2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000111596ENST00000229195Q9NZN8
ENSG00000111596ENST00000229195A0A024RBD8
ENSG00000111596ENST00000418359Q9NZN8
ENSG00000111596ENST00000418359A0A024RBD8
ENSG00000111596ENST00000546673H0YI11
ENSG00000111596ENST00000547780F8VPX5
ENSG00000111596ENST00000547867F8VRJ3
ENSG00000111596ENST00000548159F8VV52
ENSG00000111596ENST00000548338H0YI80
ENSG00000111596ENST00000548599F8VVD4
ENSG00000111596ENST00000548741F8VSK9
ENSG00000111596ENST00000549709H0YHT8
ENSG00000111596ENST00000549750F8VVY1
ENSG00000111596ENST00000550160F8VRS8
ENSG00000111596ENST00000550194F8VX63
ENSG00000111596ENST00000550641F8VUB4
ENSG00000111596ENST00000551043Q9NZN8
ENSG00000111596ENST00000551043A0A024RBD8
ENSG00000111596ENST00000551132F8VWH8
ENSG00000111596ENST00000551661F8VV05
ENSG00000111596ENST00000551710H0YHT6
ENSG00000111596ENST00000551873F8VQD8
ENSG00000111596ENST00000552151A0A087X050
ENSG00000111596ENST00000552231F8VP97
ENSG00000111596ENST00000552319F8VS14
ENSG00000111596ENST00000552483F8VQF4
ENSG00000111596ENST00000552599H0YH84
ENSG00000111596ENST00000552915F8W145
ENSG00000111596ENST00000553020F8VSK9

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
RNA degradationKEGGko03018
RNA degradationKEGGhsa03018
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
Deadenylation-dependent mRNA decayREACTOMER-HSA-429914
Deadenylation of mRNAREACTOMER-HSA-429947
TP53 Regulates Transcription of Cell Cycle GenesREACTOMER-HSA-6791312
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertainREACTOMER-HSA-6804115

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
340186732021CNOT2 haploinsufficiency in a 40-year-old man with intellectual disability, autism, and seizures.2
346801252021Inhibition of CNOT2 Induces Apoptosis via MID1IP1 in Colorectal Cancer Cells by Activating p53.10
340186732021CNOT2 haploinsufficiency in a 40-year-old man with intellectual disability, autism, and seizures.2
346801252021Inhibition of CNOT2 Induces Apoptosis via MID1IP1 in Colorectal Cancer Cells by Activating p53.10
318942592020CCR4‑NOT transcription complex subunit 2 regulates TRAIL sensitivity in non‑small‑cell lung cancer cells via the STAT3 pathway.0
318942592020CCR4‑NOT transcription complex subunit 2 regulates TRAIL sensitivity in non‑small‑cell lung cancer cells via the STAT3 pathway.0
311552932019CNOT2 facilitates dengue virus infection via negatively modulating IFN-Independent Non-Canonical JAK/STAT pathway.5
311552932019CNOT2 facilitates dengue virus infection via negatively modulating IFN-Independent Non-Canonical JAK/STAT pathway.5
290248112018CNOT2 promotes proliferation and angiogenesis via VEGF signaling in MDA-MB-231 breast cancer cells.31
290248112018CNOT2 promotes proliferation and angiogenesis via VEGF signaling in MDA-MB-231 breast cancer cells.31
286156932017The CCR4-NOT complex contributes to repression of Major Histocompatibility Complex class II transcription.15
286156932017The CCR4-NOT complex contributes to repression of Major Histocompatibility Complex class II transcription.15
272735142016The transcription factor ERG recruits CCR4-NOT to control mRNA decay and mitotic progression.24
272735142016The transcription factor ERG recruits CCR4-NOT to control mRNA decay and mitotic progression.24
241212322013Structure and assembly of the NOT module of the human CCR4-NOT complex.72

Citation

Dessen P

CNOT2 (CCR4-NOT transcription complex subunit 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-12-01

Online version: http://atlasgeneticsoncology.org/gene/40114/cnot2-(ccr4-not-transcription-complex-subunit-2)