CRIM1 (cysteine rich transmembrane BMP regulator 1)

2003-12-01 Affiliation

Identity

HGNC

CRIM1

LOCATION

2p22.2

LOCUSID

51232

ALIAS

CRIM-1,S52

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 51232
MIM: 606189
HGNC: 2359
Ensembl: ENSG00000150938

Variants:

dbSNP: 51232
ClinVar: 51232
TCGA: ENSG00000150938
COSMIC: CRIM1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000150938	ENST00000280527	Q9NZV1
ENSG00000150938	ENST00000413985	H7C1Z0
ENSG00000150938	ENST00000426856	H7C2T6
ENSG00000150938	ENST00000428774	H7C458

Expression (GTEx)

100

150

200

250

300

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
37382169	2023	CircCRIM1 mediates proliferation, migration, and invasion of trophoblast cell through regulating miR-942-5p/IL1RAP axis.	0
37807311	2023	Silencing of long non-coding RNA SDCBP2-AS1/microRNA-656-3p/CRIM1 axis promotes ferroptosis of lung cancer cells.	0
37382169	2023	CircCRIM1 mediates proliferation, migration, and invasion of trophoblast cell through regulating miR-942-5p/IL1RAP axis.	0
37807311	2023	Silencing of long non-coding RNA SDCBP2-AS1/microRNA-656-3p/CRIM1 axis promotes ferroptosis of lung cancer cells.	0
32611418	2020	Homozygote CRIM1 variant is associated with thiopurine-induced neutropenia in leukemic patients with both wildtype NUDT15 and TPMT.	3
32611418	2020	Homozygote CRIM1 variant is associated with thiopurine-induced neutropenia in leukemic patients with both wildtype NUDT15 and TPMT.	3
30365943	2019	A novel role for CRIM1 in the corneal response to UV and pterygium development.	7
30365943	2019	A novel role for CRIM1 in the corneal response to UV and pterygium development.	7
29607933	2018	Reduction of Membrane Protein CRIM1 Decreases E-Cadherin and Increases Claudin-1 and MMPs, Enhancing the Migration and Invasion of Renal Carcinoma Cells.	17
29607933	2018	Reduction of Membrane Protein CRIM1 Decreases E-Cadherin and Increases Claudin-1 and MMPs, Enhancing the Migration and Invasion of Renal Carcinoma Cells.	17
27803996	2017	CRIM1 is necessary for coronary vascular endothelial cell development and homeostasis.	7
27803996	2017	CRIM1 is necessary for coronary vascular endothelial cell development and homeostasis.	7
25561690	2015	CRIM1 haploinsufficiency causes defects in eye development in human and mouse.	15
25956066	2015	Inhibition of the proliferation and acceleration of migration of vascular endothelial cells by increased cysteine-rich motor neuron 1.	2
26653968	2015	CRIM1, a newfound cancer-related player, regulates the adhesion and migration of lung cancer cells.	17

Citation

Dessen P

CRIM1 (cysteine rich transmembrane BMP regulator 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-12-01

Online version: http://atlasgeneticsoncology.org/gene/40148/crim1-(cysteine-rich-transmembrane-bmp-regulator-1)