Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 1399
MIM: 602007
HGNC: 2363
Ensembl: ENSG00000099942
Variants:
dbSNP: 1399
ClinVar: 1399
TCGA: ENSG00000099942
COSMIC: CRKL
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000099942 | ENST00000354336 | P46109 |
| ENSG00000099942 | ENST00000411769 | P46109 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38052858 | 2024 | Cancer-associated fibroblast exosome LINC00355 promotes epithelial-mesenchymal transition and chemoresistance in colorectal cancer through the miR-34b-5p/CRKL axis. | 3 |
| 38387229 | 2024 | Exploring the short linear motif-mediated protein-protein interactions of CrkL through ProP-PD. | 0 |
| 38403027 | 2024 | CRKL dictates anti-PD-1 resistance by mediating tumor-associated neutrophil infiltration in hepatocellular carcinoma. | 0 |
| 38683131 | 2024 | CRKL but not CRKII contributes to hemin-induced erythroid differentiation of CML. | 0 |
| 38052858 | 2024 | Cancer-associated fibroblast exosome LINC00355 promotes epithelial-mesenchymal transition and chemoresistance in colorectal cancer through the miR-34b-5p/CRKL axis. | 3 |
| 38387229 | 2024 | Exploring the short linear motif-mediated protein-protein interactions of CrkL through ProP-PD. | 0 |
| 38403027 | 2024 | CRKL dictates anti-PD-1 resistance by mediating tumor-associated neutrophil infiltration in hepatocellular carcinoma. | 0 |
| 38683131 | 2024 | CRKL but not CRKII contributes to hemin-induced erythroid differentiation of CML. | 0 |
| 37121446 | 2023 | Identification of CRKL as an oncogenic biomarker for prognosis and immunotherapy in melanoma, and its potential molecular mechanism. | 1 |
| 37121446 | 2023 | Identification of CRKL as an oncogenic biomarker for prognosis and immunotherapy in melanoma, and its potential molecular mechanism. | 1 |
| 33523562 | 2021 | CRKL promotes hepatocarcinoma through enhancing glucose metabolism of cancer cells via activating PI3K/Akt. | 4 |
| 33561443 | 2021 | Quantitative assessment of glioblastoma phenotypes in vitro establishes cell migration as a robust readout of Crk and CrkL activity. | 1 |
| 34114685 | 2021 | Silencing of the CrkL gene reverses the doxorubicin resistance of K562/ADR cells through regulating PI3K/Akt/MRP1 signaling. | 1 |
| 34196458 | 2021 | Central 22q11.2 deletion (LCR22 B-D) in a fetus with severe fetal growth restriction and a mother with severe systemic lupus erythematosus: Further evidence of CRKL haploinsufficiency in the pathogenesis of 22q11.2 deletion syndrome. | 4 |
| 34209812 | 2021 | Bifunctional Role of CrkL during Bone Remodeling. | 1 |
Citation
Dessen P
CRKL (CRK like proto-oncogene, adaptor protein)
Atlas Genet Cytogenet Oncol Haematol. 2003-02-01
Online version: http://atlasgeneticsoncology.org/gene/40150
