CRMP1 (collapsin response mediator protein 1)

2003-02-01  

Identity

HGNC
CRMP1
LOCATION
4p16.2
LOCUSID
1400
ALIAS
CRMP-1,DPYSL1,DRP-1,DRP1,ULIP-3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 1400
MIM: 602462
HGNC: 2365
Ensembl: ENSG00000072832

Variants:

dbSNP: 1400
ClinVar: 1400
TCGA: ENSG00000072832
COSMIC: CRMP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000072832ENST00000324989Q14194
ENSG00000072832ENST00000324989X5DNI1
ENSG00000072832ENST00000397890Q14194
ENSG00000072832ENST00000512574E9PD68

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
Semaphorin interactionsREACTOMER-HSA-373755
CRMPs in Sema3A signalingREACTOMER-HSA-399956

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
161690702005A human protein-protein interaction network: a resource for annotating the proteome.843
166116312006Distinct priming kinases contribute to differential regulation of collapsin response mediator proteins by glycogen synthase kinase-3 in vivo.71
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
149968582004Connective tissue growth factor and its role in lung adenocarcinoma invasion and metastasis.49
217471642011The ability of LCRMP-1 to promote cancer invasion by enhancing filopodia formation is antagonized by CRMP-1.31
126506092003Collapsin response mediator protein-1: a novel invasion-suppressor gene.23
260329582015Activation of the Mitochondrial Fragmentation Protein DRP1 Correlates with BRAF(V600E) Melanoma.21
227986272012Proteomic, genomic and translational approaches identify CRMP1 for a role in schizophrenia and its underlying traits.20
124826102002p80 ROKalpha binding protein is a novel splice variant of CRMP-1 which associates with CRMP-2 and modulates RhoA-induced neuronal morphology.17
193623862010Long form collapsin response mediator protein-1 (LCRMP-1) expression is associated with clinical outcome and lymph node metastasis in non-small cell lung cancer patients.16

Citation

Dessen P

CRMP1 (collapsin response mediator protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40151/crmp1-(collapsin-response-mediator-protein-1)