MED23 (mediator complex subunit 23)

2003-06-01  

Identity

HGNC
LOCATION
6q23.2
LOCUSID
ALIAS
ARC130,CRSP130,CRSP133,CRSP3,DRIP130,MRT18,SUR-2,SUR2
FUSION GENES

Other Information

Locus ID:

NCBI: 9439
MIM: 605042
HGNC: 2372
Ensembl: ENSG00000112282

Variants:

dbSNP: 9439
ClinVar: 9439
TCGA: ENSG00000112282
COSMIC: MED23

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000112282ENST00000354577Q9ULK4
ENSG00000112282ENST00000368053Q9ULK4
ENSG00000112282ENST00000368058Q5JWT2
ENSG00000112282ENST00000368060Q9ULK4
ENSG00000112282ENST00000368068Q9ULK4
ENSG00000112282ENST00000539158Q9ULK4

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolismREACTOMER-HSA-535734
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)REACTOMER-HSA-400206
PPARA activates gene expressionREACTOMER-HSA-1989781
Developmental BiologyREACTOMER-HSA-1266738
Transcriptional regulation of white adipocyte differentiationREACTOMER-HSA-381340

References

Pubmed IDYearTitleCitations
379999792023LINC00921 reduces lung cancer radiosensitivity by destabilizing NUDT21 and driving aberrant MED23 alternative polyadenylation.0
379999792023LINC00921 reduces lung cancer radiosensitivity by destabilizing NUDT21 and driving aberrant MED23 alternative polyadenylation.0
301400542018Crystal structure of human Mediator subunit MED23.9
301400542018Crystal structure of human Mediator subunit MED23.9
273119652016MED23-associated refractory epilepsy successfully treated with the ketogenic diet.7
275798962016A 7-Gene Signature Depicts the Biochemical Profile of Early Prefibrotic Myelofibrosis.5
279145002016Effect of l-arginine, asymmetric dimethylarginine, and symmetric dimethylarginine on ischemic heart disease risk: A Mendelian randomization study.9
273119652016MED23-associated refractory epilepsy successfully treated with the ketogenic diet.7
275798962016A 7-Gene Signature Depicts the Biochemical Profile of Early Prefibrotic Myelofibrosis.5
279145002016Effect of l-arginine, asymmetric dimethylarginine, and symmetric dimethylarginine on ischemic heart disease risk: A Mendelian randomization study.9
256843932015Mediator subunit 23 overexpression as a novel target for suppressing proliferation and tumorigenesis in hepatocellular carcinoma.10
258454692015MED23-associated intellectual disability in a non-consanguineous family.12
261528462015Mutational Heterogeneity of MED23 Gene in Colorectal Cancers.3
256843932015Mediator subunit 23 overexpression as a novel target for suppressing proliferation and tumorigenesis in hepatocellular carcinoma.10
258454692015MED23-associated intellectual disability in a non-consanguineous family.12

Citation

Dessen P

MED23 (mediator complex subunit 23)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/40153/med23-(mediator-complex-subunit-23)