CSF3 (colony stimulating factor 3)

2003-02-01  

Identity

HGNC
CSF3
LOCATION
17q21.1
LOCUSID
1440
ALIAS
C17orf33,CSF3OS,GCSF

Other Information

Locus ID:

NCBI: 1440
MIM: 138970
HGNC: 2438
Ensembl: ENSG00000108342

Variants:

dbSNP: 1440
ClinVar: 1440
TCGA: ENSG00000108342
COSMIC: CSF3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000108342ENST00000225474P09919
ENSG00000108342ENST00000331769Q8N4W3
ENSG00000108342ENST00000394148P09919
ENSG00000108342ENST00000394149P09919
ENSG00000108342ENST00000394149Q6FH65
ENSG00000108342ENST00000577675J3KTH8
ENSG00000108342ENST00000579852J3QRD4
ENSG00000108342ENST00000583218J3QRX2

Expression (GTEx)

0
5
10
15
20
25
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Jak-STAT signaling pathwayKEGGko04630
Hematopoietic cell lineageKEGGko04640
Cytokine-cytokine receptor interactionKEGGhsa04060
Jak-STAT signaling pathwayKEGGhsa04630
Hematopoietic cell lineageKEGGhsa04640
MalariaKEGGko05144
MalariaKEGGhsa05144
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Interleukin-10 signalingREACTOMER-HSA-6783783
IL-17 signaling pathwayKEGGko04657
IL-17 signaling pathwayKEGGhsa04657

References

Pubmed IDYearTitleCitations
160373942005G-CSF potently inhibits osteoblast activity and CXCL12 mRNA expression in the bone marrow.157
177034122007Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.100
120345752002Interleukin-17 stimulates the expression of interleukin-8, growth-related oncogene-alpha, and granulocyte-colony-stimulating factor by human airway epithelial cells.90
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
210796122011Mechanisms of G-CSF-mediated hematopoietic stem and progenitor mobilization.75
189528972009Serum amyloid A induces G-CSF expression and neutrophilia via Toll-like receptor 2.67
167355972006G-CSF and AMD3100 mobilize monocytes into the blood that stimulate angiogenesis in vivo through a paracrine mechanism.60
212244712011G-CSF-mediated thrombopoietin release triggers neutrophil motility and mobilization from bone marrow via induction of Cxcr2 ligands.58
118772882002Effects of administration of progenipoietin 1, Flt-3 ligand, granulocyte colony-stimulating factor, and pegylated granulocyte-macrophage colony-stimulating factor on dendritic cell subsets in mice.48
126767912003G-CSF as immune regulator in T cells expressing the G-CSF receptor: implications for transplantation and autoimmune diseases.47

Citation

Dessen P

CSF3 (colony stimulating factor 3)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40164/csf3-(colony-stimulating-factor-3)