Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 1445
MIM: 124095
HGNC: 2444
Ensembl: ENSG00000103653
Variants:
dbSNP: 1445
ClinVar: 1445
TCGA: ENSG00000103653
COSMIC: CSK
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA30086 | KDR | Gene | Pathway | associated | 20124951 | ||
| PA34183 | RAF1 | Gene | Pathway | associated | 20124951 | ||
| PA444552 | Hypertension | Disease | ClinicalAnnotation | associated | PD | 31327267 | |
| PA449899 | hydrochlorothiazide | Chemical | ClinicalAnnotation | associated | PD | 31327267 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 35393453 | 2022 | SH3-domain mutations selectively disrupt Csk homodimerization or PTPN22 binding. | 4 |
| 35393453 | 2022 | SH3-domain mutations selectively disrupt Csk homodimerization or PTPN22 binding. | 4 |
| 33887528 | 2021 | Molecular mapping of platelet hyperreactivity in diabetes: the stress proteins complex HSPA8/Hsp90/CSK2α and platelet aggregation in diabetic and normal platelets. | 6 |
| 33887528 | 2021 | Molecular mapping of platelet hyperreactivity in diabetes: the stress proteins complex HSPA8/Hsp90/CSK2α and platelet aggregation in diabetic and normal platelets. | 6 |
| 32201077 | 2020 | CSK promotes innate immune response to DNA virus by phosphorylating MITA. | 10 |
| 32376886 | 2020 | Depletion of Csk preferentially reduces the protein level of LynA in a Cbl-dependent manner in cancer cells. | 2 |
| 32201077 | 2020 | CSK promotes innate immune response to DNA virus by phosphorylating MITA. | 10 |
| 32376886 | 2020 | Depletion of Csk preferentially reduces the protein level of LynA in a Cbl-dependent manner in cancer cells. | 2 |
| 31125786 | 2019 | SUMOylation of Csk Negatively Modulates its Tumor Suppressor Function. | 5 |
| 31292214 | 2019 | Carboxyl-Terminal Src Kinase Binds CD28 upon Activation and Mutes Downstream Signaling. | 3 |
| 31125786 | 2019 | SUMOylation of Csk Negatively Modulates its Tumor Suppressor Function. | 5 |
| 31292214 | 2019 | Carboxyl-Terminal Src Kinase Binds CD28 upon Activation and Mutes Downstream Signaling. | 3 |
| 29503074 | 2018 | Dimerization of the Pragmin Pseudo-Kinase Regulates Protein Tyrosine Phosphorylation. | 21 |
| 30041015 | 2018 | Oligodendrocyte differentiation from human neural stem cells: A novel role for c-Src. | 5 |
| 30116247 | 2018 | Positive and Negative Regulatory Roles of C-Terminal Src Kinase (CSK) in FcεRI-Mediated Mast Cell Activation, Independent of the Transmembrane Adaptor PAG/CSK-Binding Protein. | 8 |
Citation
Dessen P
CSK (C-terminal Src kinase)
Atlas Genet Cytogenet Oncol Haematol. 2003-02-01
Online version: http://atlasgeneticsoncology.org/gene/40166/csk-(c-terminal-src-kinase)
