CTAG2 (cancer/testis antigen 2)

2003-06-01  

Identity

HGNC
CTAG2
LOCATION
Xq28
LOCUSID
30848
ALIAS
CAMEL,CT2,CT6.2,CT6.2a,CT6.2b,ESO2,LAGE-1,LAGE2B

Other Information

Locus ID:

NCBI: 30848
MIM: 300396
HGNC: 2492
Ensembl: ENSG00000126890

Variants:

dbSNP: 30848
ClinVar: 30848
TCGA: ENSG00000126890
COSMIC: CTAG2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000126890ENST00000247306O75638
ENSG00000126890ENST00000369585O75638

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
145229382003NY-ESO-1 and LAGE-1 cancer-testis antigens are potential targets for immunotherapy in epithelial ovarian cancer.91
182371052008Prognostic impact of cancer/testis antigen expression in advanced stage multiple myeloma patients.49
223841672012NYESO-1/LAGE-1s and PRAME are targets for antigen specific T cells in chondrosarcoma following treatment with 5-Aza-2-deoxycitabine.16
155402282005Dominant B cell epitope from NY-ESO-1 recognized by sera from a wide spectrum of cancer patients: implications as a potential biomarker.12
125387122003CD4+ Th2 cell recognition of HLA-DR-restricted epitopes derived from CAMEL: a tumor antigen translated in an alternative open reading frame.10
145598442003The alternative open reading frame of LAGE-1 gives rise to multiple promiscuous HLA-DR-restricted epitopes recognized by T-helper 1-type tumor-reactive CD4+ T cells.10
192126312009Comparisons for detecting NY-ESO-1 mRNA expression levels in hepatocellular carcinoma tissues.8
248852972014Reexpression of LSAMP inhibits tumor growth in a preclinical osteosarcoma model.8
164465482006A new specific gene expression in squamous cell carcinoma of the esophagus detected using representational difference analysis and cDNA microarray.5
211314222011Epitope hierarchy of spontaneous CD4+ T cell responses to LAGE-1.5

Citation

Dessen P

CTAG2 (cancer/testis antigen 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/40184/ctag2-(cancer-testis-antigen-2)