CTBP1 (C-terminal binding protein 1)

2003-02-01  

Identity

HGNC
CTBP1
LOCATION
4p16.3
LOCUSID
1487
ALIAS
BARS,HADDTS
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 1487
MIM: 602618
HGNC: 2494
Ensembl: ENSG00000159692

Variants:

dbSNP: 1487
ClinVar: 1487
TCGA: ENSG00000159692
COSMIC: CTBP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000159692ENST00000290921Q13363
ENSG00000159692ENST00000290921X5D8Y5
ENSG00000159692ENST00000382952Q13363
ENSG00000159692ENST00000503594H0Y8U5
ENSG00000159692ENST00000504092H0Y8W7
ENSG00000159692ENST00000504784H0Y913
ENSG00000159692ENST00000506180D6RAX2
ENSG00000159692ENST00000510568E7EUB3
ENSG00000159692ENST00000510739H0Y9M9
ENSG00000159692ENST00000513420E9PGB1
ENSG00000159692ENST00000514210E7EPF8
ENSG00000159692ENST00000515399E7ESU7
ENSG00000159692ENST00000629223A0A0D9SGE6

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Wnt signaling pathwayKEGGko04310
Notch signaling pathwayKEGGko04330
Chronic myeloid leukemiaKEGGko05220
Wnt signaling pathwayKEGGhsa04310
Notch signaling pathwayKEGGhsa04330
Pathways in cancerKEGGhsa05200
Chronic myeloid leukemiaKEGGhsa05220
DiseaseREACTOMER-HSA-1643685
Diseases of signal transductionREACTOMER-HSA-5663202
Signaling by WNT in cancerREACTOMER-HSA-4791275
TCF7L2 mutants don't bind CTBPREACTOMER-HSA-5339700
Signal TransductionREACTOMER-HSA-162582
Signaling by WntREACTOMER-HSA-195721
Degradation of beta-catenin by the destruction complexREACTOMER-HSA-195253
Repression of WNT target genesREACTOMER-HSA-4641265
TCF dependent signaling in response to WNTREACTOMER-HSA-201681
Deactivation of the beta-catenin transactivating complexREACTOMER-HSA-3769402

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
366298822023Elevation of hsa-miR-7-5p level mediated by CtBP1-p300-AP1 complex targets ATXN1 to trigger NF-κB-dependent inflammation response.0
366889592023The CRL4(DCAF6) E3 ligase ubiquitinates CtBP1/2 to induce apoptotic signalling and promote intervertebral disc degeneration.4
367642102023Succinylation of CTBP1 mediated by KAT2A suppresses its inhibitory activity on the transcription of CDH1 to promote the progression of prostate cancer.5
366298822023Elevation of hsa-miR-7-5p level mediated by CtBP1-p300-AP1 complex targets ATXN1 to trigger NF-κB-dependent inflammation response.0
366889592023The CRL4(DCAF6) E3 ligase ubiquitinates CtBP1/2 to induce apoptotic signalling and promote intervertebral disc degeneration.4
367642102023Succinylation of CTBP1 mediated by KAT2A suppresses its inhibitory activity on the transcription of CDH1 to promote the progression of prostate cancer.5
349979672022NADH/NAD(+) binding and linked tetrameric assembly of the oncogenic transcription factors CtBP1 and CtBP2.4
363316892022CTBP1 and CTBP2 mutations underpinning neurological disorders: a systematic review.3
349979672022NADH/NAD(+) binding and linked tetrameric assembly of the oncogenic transcription factors CtBP1 and CtBP2.4
363316892022CTBP1 and CTBP2 mutations underpinning neurological disorders: a systematic review.3
325834252021LINC01426 contributes to clear cell renal cell carcinoma progression by modulating CTBP1/miR-423-5p/FOXM1 axis via interacting with IGF2BP1.16
332646052021Cryo-EM structure of CtBP2 confirms tetrameric architecture.13
335243972021NAD(H) phosphates mediate tetramer assembly of human C-terminal binding protein (CtBP).5
341470292021Downregulation of HERC5 E3 ligase attenuates the ubiquitination of CtBP1 to inhibit apoptosis in colorectal cancer cells.6
345867412021CircIMMP2L promotes esophageal squamous cell carcinoma malignant progression via CtBP1 nuclear retention dependent epigenetic modification.5

Citation

Dessen P

CTBP1 (C-terminal binding protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40185/ctbp1-(c-terminal-binding-protein-1)