CTBP2 (C-terminal binding protein 2)

2003-05-01 Affiliation

Identity

HGNC

CTBP2

LOCATION

10q26.13

LOCUSID

1488

ALIAS

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 1488
MIM: 602619
HGNC: 2495
Ensembl: ENSG00000175029

Variants:

dbSNP: 1488
ClinVar: 1488
TCGA: ENSG00000175029
COSMIC: CTBP2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000175029	ENST00000309035	P56545
ENSG00000175029	ENST00000334808	P56545
ENSG00000175029	ENST00000337195	P56545
ENSG00000175029	ENST00000395705	A0A087WYL1
ENSG00000175029	ENST00000411419	P56545
ENSG00000175029	ENST00000494626	P56545
ENSG00000175029	ENST00000531469	P56545

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Wnt signaling pathway	KEGG	ko04310
Notch signaling pathway	KEGG	ko04330
Chronic myeloid leukemia	KEGG	ko05220
Wnt signaling pathway	KEGG	hsa04310
Notch signaling pathway	KEGG	hsa04330
Pathways in cancer	KEGG	hsa05200
Chronic myeloid leukemia	KEGG	hsa05220
Disease	REACTOME	R-HSA-1643685
Diseases of signal transduction	REACTOME	R-HSA-5663202
Signaling by WNT in cancer	REACTOME	R-HSA-4791275
TCF7L2 mutants don't bind CTBP	REACTOME	R-HSA-5339700
Signal Transduction	REACTOME	R-HSA-162582
Signaling by Wnt	REACTOME	R-HSA-195721
Degradation of beta-catenin by the destruction complex	REACTOME	R-HSA-195253
Repression of WNT target genes	REACTOME	R-HSA-4641265

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
18264096	2008	Multiple loci identified in a genome-wide association study of prostate cancer.	448
19240061	2009	Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.	75
16385451	2006	A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.	69
20379614	2010	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.	62
19318432	2009	Generalizability of associations from prostate cancer genome-wide association studies in multiple populations.	60
21071540	2011	Validation of genome-wide prostate cancer associations in men of African descent.	51
19902474	2010	Replication of prostate cancer risk loci on 8q24, 11q13, 17q12, 19q33, and Xp11 in African Americans.	39
19900942	2009	Prognostic significance of prostate cancer susceptibility variants on prostate-specific antigen recurrence after radical prostatectomy.	38
19549807	2009	Prostate cancer risk associated loci in African Americans.	37
20564319	2010	Prostate cancer risk-associated variants reported from genome-wide association studies: meta-analysis and their contribution to genetic Variation.	36

Citation

Dessen P

CTBP2 (C-terminal binding protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/40186/ctbp2-(c-terminal-binding-protein-2)