CTF1 (cardiotrophin 1)

2003-12-01  

Identity

HGNC
LOCATION
16p11.2
LOCUSID
ALIAS
CT-1,CT1
FUSION GENES

Other Information

Locus ID:

NCBI: 1489
MIM: 600435
HGNC: 2499
Ensembl: ENSG00000150281

Variants:

dbSNP: 1489
ClinVar: 1489
TCGA: ENSG00000150281
COSMIC: CTF1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000150281ENST00000279804Q16619
ENSG00000150281ENST00000395019Q16619

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Jak-STAT signaling pathwayKEGGko04630
Cytokine-cytokine receptor interactionKEGGhsa04060
Jak-STAT signaling pathwayKEGGhsa04630
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Interleukin-6 family signalingREACTOMER-HSA-6783589
IL-6-type cytokine receptor ligand interactionsREACTOMER-HSA-6788467

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
179402132008Cardiotrophin-1 is expressed in adipose tissue and upregulated in the metabolic syndrome.23
204740832010A novel custom resequencing array for dilated cardiomyopathy.20
122349452002Augmented expression of cardiotrophin-1 in failing human hearts is accompanied by diminished glycoprotein 130 receptor protein abundance.16
153399202004Effects of cardiotrophin on adipocytes.16
127072692003Leukemia inhibitory factor (LIF), cardiotrophin-1, and oncostatin M share structural binding determinants in the immunoglobulin-like domain of LIF receptor.15
191557932009Association of plasma cardiotrophin-1 with stage C heart failure in hypertensive patients: potential diagnostic implications.13
243660782014Association of cardiotrophin-1 with myocardial fibrosis in hypertensive patients with heart failure.13
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11
192736042009Transcription factor CTF1 acts as a chromatin domain boundary that shields human telomeric genes from silencing.9

Citation

Dessen P

CTF1 (cardiotrophin 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-12-01

Online version: http://atlasgeneticsoncology.org/gene/40191/ctf1-(cardiotrophin-1)