CTPS2 (CTP synthase 2)

2003-05-01  

Identity

HGNC
LOCATION
Xp22.2
LOCUSID
ALIAS
GATD5B
FUSION GENES

Other Information

Locus ID:

NCBI: 56474
MIM: 300380
HGNC: 2520
Ensembl: ENSG00000047230

Variants:

dbSNP: 56474
ClinVar: 56474
TCGA: ENSG00000047230
COSMIC: CTPS2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000047230ENST00000359276Q9NRF8
ENSG00000047230ENST00000359276A0A024RC00
ENSG00000047230ENST00000380241Q9NRF8
ENSG00000047230ENST00000380241A0A024RC00
ENSG00000047230ENST00000443824Q9NRF8
ENSG00000047230ENST00000443824A0A024RC00
ENSG00000047230ENST00000455276H0Y5S6

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
Pyrimidine metabolismKEGGko00240
Pyrimidine metabolismKEGGhsa00240
Metabolic pathwaysKEGGhsa01100
Pyrimidine ribonucleotide biosynthesis, UMP => UDP/UTP,CDP/CTPKEGGhsa_M00052
Pyrimidine ribonucleotide biosynthesis, UMP => UDP/UTP,CDP/CTPKEGGM00052
MetabolismREACTOMER-HSA-1430728
Metabolism of nucleotidesREACTOMER-HSA-15869
Synthesis and interconversion of nucleotide di- and triphosphatesREACTOMER-HSA-499943

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
318733032020Coupled structural transitions enable highly cooperative regulation of human CTPS2 filaments.35
318733032020Coupled structural transitions enable highly cooperative regulation of human CTPS2 filaments.35
212522872011Comprehensive evaluation of the contribution of X chromosome genes to platinum sensitivity.4
213785022011Low cytosine triphosphate synthase 2 expression renders resistance to 5-fluorouracil in colorectal cancer.8
212522872011Comprehensive evaluation of the contribution of X chromosome genes to platinum sensitivity.4
213785022011Low cytosine triphosphate synthase 2 expression renders resistance to 5-fluorouracil in colorectal cancer.8
207392752010Regulation of human cytidine triphosphate synthetase 2 by phosphorylation.23
207392752010Regulation of human cytidine triphosphate synthetase 2 by phosphorylation.23

Citation

Dessen P

CTPS2 (CTP synthase 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/40200/ctps2-(ctp-synthase-2)