CTRC (chymotrypsin C)

2003-05-01  

Identity

HGNC
CTRC
LOCATION
1p36.21
LOCUSID
11330
ALIAS
CLCR,ELA4
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 11330
MIM: 601405
HGNC: 2523
Ensembl: ENSG00000162438

Variants:

dbSNP: 11330
ClinVar: 11330
TCGA: ENSG00000162438
COSMIC: CTRC

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000162438ENST00000375943Q68DR9
ENSG00000162438ENST00000375949Q99895

Expression (GTEx)

0
500
1000
1500
2000
2500
3000
3500
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Metabolism of vitamins and cofactorsREACTOMER-HSA-196854
Metabolism of water-soluble vitamins and cofactorsREACTOMER-HSA-196849
Cobalamin (Cbl, vitamin B12) transport and metabolismREACTOMER-HSA-196741

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
373219412023Risk of chronic pancreatitis in carriers of the c.180C>T (p.Gly60=) CTRC variant: case-control studies and meta-analysis.2
373219412023Risk of chronic pancreatitis in carriers of the c.180C>T (p.Gly60=) CTRC variant: case-control studies and meta-analysis.2
355942812022Risk of chronic pancreatitis in carriers of loss-of-function CTRC variants: A meta-analysis.3
355942812022Risk of chronic pancreatitis in carriers of loss-of-function CTRC variants: A meta-analysis.3
318621842020Chronic pancreatitis with polycystic kidney disease: A rare coincidence?1
320149972020Inactivation of mesotrypsin by chymotrypsin C prevents trypsin inhibitor degradation.7
320457772020Association between genetic variants in CYP2E1 and CTRC genes and susceptibility to alcoholic pancreatitis: A systematic review and meta-analysis.1
329484272020Clinical interpretation of SPINK1 and CTRC variants in pancreatitis.4
318621842020Chronic pancreatitis with polycystic kidney disease: A rare coincidence?1
320149972020Inactivation of mesotrypsin by chymotrypsin C prevents trypsin inhibitor degradation.7
320457772020Association between genetic variants in CYP2E1 and CTRC genes and susceptibility to alcoholic pancreatitis: A systematic review and meta-analysis.1
329484272020Clinical interpretation of SPINK1 and CTRC variants in pancreatitis.4
302776692019Do CTRC mutations affect the development of alcoholic chronic pancreatitis and its course among Poles: Preliminary study.2
302776692019Do CTRC mutations affect the development of alcoholic chronic pancreatitis and its course among Poles: Preliminary study.2
280957862017CTRC gene polymorphism (p.G60=; c.180 C > T) in acute pancreatitis.3

Citation

Dessen P

CTRC (chymotrypsin C)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/40201/ctrc-(chymotrypsin-c)