CUL4B (cullin 4B)

Identity

HGNC

CUL4B

LOCATION

Xq24

LOCUSID

8450

ALIAS

CUL-4B,MRXHF2,MRXS15,MRXSC,SFM2

FUSION GENES

Show Gene Fusions

Other Information

Locus ID:

NCBI: 8450
MIM: 300304
HGNC: 2555
Ensembl: ENSG00000158290

Variants:

dbSNP: 8450
ClinVar: 8450
TCGA: ENSG00000158290
COSMIC: CUL4B

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000158290	ENST00000336592	K4DI93
ENSG00000158290	ENST00000371322	Q13620
ENSG00000158290	ENST00000371323	A6NE76
ENSG00000158290	ENST00000404115	Q13620

Expression (GTEx)

0

10

20

30

40

50

60

70

80

90

100

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Cul4-DDB1-CSA complex	KEGG	hsa_M00386
Cul4-DDB1-CSA complex	KEGG	M00386
Cul4-DDB1-DDB2 complex	KEGG	hsa_M00385
Cul4-DDB1-DDB2 complex	KEGG	M00385
DNA Damage Bypass	REACTOME	R-HSA-73893
DNA Damage Recognition in GG-NER	REACTOME	R-HSA-5696394
DNA Repair	REACTOME	R-HSA-73894
Dual Incision in GG-NER	REACTOME	R-HSA-5696400
Dual incision in TC-NER	REACTOME	R-HSA-6782135
Formation of Incision Complex in GG-NER	REACTOME	R-HSA-5696395

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Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
36476360	2023	CUL4B-associated epilepsy: Report of a novel truncating variant promoting drug-resistant seizures and systematic review of the literature.	2
36476360	2023	CUL4B-associated epilepsy: Report of a novel truncating variant promoting drug-resistant seizures and systematic review of the literature.	2
36939378	2023	MEN1 Degradation Induced by Neddylation and the CUL4B-DCAF7 Axis Promotes Pancreatic Neuroendocrine Tumor Progression.	4
36939378	2023	MEN1 Degradation Induced by Neddylation and the CUL4B-DCAF7 Axis Promotes Pancreatic Neuroendocrine Tumor Progression.	4
37158446	2023	Knockdown of circMFN2 inhibits cell progression and glycolysis by miR-198/CUL4B pathway in ovarian cancer.	2
37158446	2023	Knockdown of circMFN2 inhibits cell progression and glycolysis by miR-198/CUL4B pathway in ovarian cancer.	2
37365982	2023	The CUL4B-based E3 ubiquitin ligase regulates mitosis and brain development by recruiting phospho-specific DCAFs.	3
37365982	2023	The CUL4B-based E3 ubiquitin ligase regulates mitosis and brain development by recruiting phospho-specific DCAFs.	3
37686215	2023	Cullin 4B Ubiquitin Ligase Is Important for Cell Survival and Regulates TGF-β1 Expression in Pleural Mesothelioma.	1
38254314	2024	Circ_0011058 alleviates RA pathology through the circ_0011058/miR-335-5p/CUL4B signal axis.	0

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Citation

Dessen P

CUL4B (cullin 4B)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40215/cul4b-(cullin-4b)