CUL5 (cullin 5)

2003-06-01  

Identity

HGNC
LOCATION
11q22.3
LOCUSID
ALIAS
CUL-5,VACM-1,VACM1
FUSION GENES

Other Information

Locus ID:

NCBI: 8065
MIM: 601741
HGNC: 2556
Ensembl: ENSG00000166266

Variants:

dbSNP: 8065
ClinVar: 8065
TCGA: ENSG00000166266
COSMIC: CUL5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000166266ENST00000393094Q93034
ENSG00000166266ENST00000531427Q93034
ENSG00000166266ENST00000532064E9PP19
ENSG00000166266ENST00000532782H0YCA0

Expression (GTEx)

0
5
10
15
20
25

Pathways

PathwaySourceExternal ID
Ubiquitin mediated proteolysisKEGGko04120
Ubiquitin mediated proteolysisKEGGhsa04120
ECS complexKEGGhsa_M00388
ECS complexKEGGM00388
DiseaseREACTOMER-HSA-1643685
Infectious diseaseREACTOMER-HSA-5663205
HIV InfectionREACTOMER-HSA-162906
Host Interactions of HIV factorsREACTOMER-HSA-162909
Vif-mediated degradation of APOBEC3GREACTOMER-HSA-180585
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168
Signal TransductionREACTOMER-HSA-162582
Signaling by ERBB2REACTOMER-HSA-1227986
Downregulation of ERBB2 signalingREACTOMER-HSA-8863795

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
145640142003Induction of APOBEC3G ubiquitination and degradation by an HIV-1 Vif-Cul5-SCF complex.579
155745922004Phosphorylation of a novel SOCS-box regulates assembly of the HIV-1 Vif-Cul5 complex that promotes APOBEC3G degradation.161
166360532006A zinc-binding region in Vif binds Cul5 and determines cullin selection.104
157814492005Ubiquitination of APOBEC3G by an HIV-1 Vif-Cullin5-Elongin B-Elongin C complex is essential for Vif function.94
244022812014Structural basis for hijacking CBF-β and CUL5 E3 ligase complex by HIV-1 Vif.87
165307992006Assembly of HIV-1 Vif-Cul5 E3 ubiquitin ligase through a novel zinc-binding domain-stabilized hydrophobic interface in Vif.76
179749152007Cullin 5 regulates Dab1 protein levels and neuron positioning during cortical development.67
199333252009Regulation of Hsp90 client proteins by a Cullin5-RING E3 ubiquitin ligase.47
172570572007Polymorphisms of CUL5 are associated with CD4+ T cell loss in HIV-1 infected individuals.31
173511292007Adenovirus E4orf6 assembles with Cullin5-ElonginB-ElonginC E3 ubiquitin ligase through an HIV/SIV Vif-like BC-box to regulate p53.26

Citation

Dessen P

CUL5 (cullin 5)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/40216/cul5-(cullin-5)