CXCL13 (C-X-C motif chemokine ligand 13)

2003-06-01  

Identity

HGNC
LOCATION
4q21.1
LOCUSID
ALIAS
ANGIE,ANGIE2,BCA-1,BCA1,BLC,BLR1L,SCYB13

Other Information

Locus ID:

NCBI: 10563
MIM: 605149
HGNC: 10639
Ensembl: ENSG00000156234

Variants:

dbSNP: 10563
ClinVar: 10563
TCGA: ENSG00000156234
COSMIC: CXCL13

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000156234ENST00000286758O43927
ENSG00000156234ENST00000286758Q53X90

Expression (GTEx)

0
100
200
300
400
500
600

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Cytokine-cytokine receptor interactionKEGGhsa04060
Chemokine signaling pathwayKEGGko04062
Chemokine signaling pathwayKEGGhsa04062
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
Chemokine receptors bind chemokinesREACTOMER-HSA-380108
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA451261rituximabChemicalMultilinkAnnotationassociated26384320

References

Pubmed IDYearTitleCitations
241388852013Spatiotemporal dynamics of intratumoral immune cells reveal the immune landscape in human cancer.460
129492492003Many chemokines including CCL20/MIP-3alpha display antimicrobial activity.154
177034122007Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.100
269088752016CXCL13 is a plasma biomarker of germinal center activity.88
127326602003Overlapping roles of CXCL13, interleukin 7 receptor alpha, and CCR7 ligands in lymph node development.75
152841192004Monocyte-like and mature macrophages produce CXCL13 (B cell-attracting chemokine 1) in inflammatory lesions with lymphoid neogenesis.69
210847532010The proteoglycan biglycan regulates expression of the B cell chemoattractant CXCL13 and aggravates murine lupus nephritis.69
225918622012CXCL13 is the major determinant for B cell recruitment to the CSF during neuroinflammation.67
159340822005Association of CXCL13 and CCL21 expression with the progressive organization of lymphoid-like structures in Sjögren's syndrome.59
199960752009Increased cerebrospinal fluid concentrations of the chemokine CXCL13 in active MS.59

Citation

Dessen P

CXCL13 (C-X-C motif chemokine ligand 13)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/40220/cxcl13-(c-x-c-motif-chemokine-ligand-13)