CXCR4 (C-X-C motif chemokine receptor 4)

2003-02-01 Affiliation

Identity

HGNC

CXCR4

LOCATION

2q22.1

LOCUSID

7852

ALIAS

CD184,D2S201E,FB22,HM89,HSY3RR,LAP-3,LAP3,LCR1,LESTR,NPY3R,NPYR,NPYRL,NPYY3R,WHIM,WHIMS

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 7852
MIM: 162643
HGNC: 2561
Ensembl: ENSG00000121966

Variants:

dbSNP: 7852
ClinVar: 7852
TCGA: ENSG00000121966
COSMIC: CXCR4

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000121966	ENST00000241393	P61073
ENSG00000121966	ENST00000409817	P61073

Expression (GTEx)

100

150

200

250

300

350

400

450

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Cytokine-cytokine receptor interaction	KEGG	ko04060
Axon guidance	KEGG	ko04360
Leukocyte transendothelial migration	KEGG	ko04670
Cytokine-cytokine receptor interaction	KEGG	hsa04060
Axon guidance	KEGG	hsa04360
Leukocyte transendothelial migration	KEGG	hsa04670
Pathways in cancer	KEGG	hsa05200
Chemokine signaling pathway	KEGG	ko04062
Chemokine signaling pathway	KEGG	hsa04062
Endocytosis	KEGG	ko04144
Endocytosis	KEGG	hsa04144
Intestinal immune network for IgA production	KEGG	ko04672
Intestinal immune network for IgA production	KEGG	hsa04672
Disease	REACTOME	R-HSA-1643685
Infectious disease	REACTOME	R-HSA-5663205
HIV Infection	REACTOME	R-HSA-162906
HIV Life Cycle	REACTOME	R-HSA-162587
Early Phase of HIV Life Cycle	REACTOME	R-HSA-162594
Binding and entry of HIV virion	REACTOME	R-HSA-173107
Signal Transduction	REACTOME	R-HSA-162582
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR ligand binding	REACTOME	R-HSA-500792
Class A/1 (Rhodopsin-like receptors)	REACTOME	R-HSA-373076
Peptide ligand-binding receptors	REACTOME	R-HSA-375276
Chemokine receptors bind chemokines	REACTOME	R-HSA-380108
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (i) signalling events	REACTOME	R-HSA-418594

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA130232992	bevacizumab	Chemical	ClinicalAnnotation	associated		PD	27503580
PA446108	Colorectal Neoplasms	Disease	ClinicalAnnotation	associated		PD	27503580

References

Pubmed ID	Year	Title	Citations
20929726	2010	Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists.	624
17435771	2007	MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment.	380
15608062	2004	Directed migration of neural stem cells to sites of CNS injury by the stromal cell-derived factor 1alpha/CXC chemokine receptor 4 pathway.	323
11912162	2002	Use of the stromal cell-derived factor-1/CXCR4 pathway in prostate cancer metastasis to bone.	303
13679920	2003	Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL.	251
14597738	2003	Regulation of the chemokine receptor CXCR4 by hypoxia.	232
12690099	2003	NF-kappaB promotes breast cancer cell migration and metastasis by inducing the expression of the chemokine receptor CXCR4.	204
22370717	2012	HMGB1 promotes recruitment of inflammatory cells to damaged tissues by forming a complex with CXCL12 and signaling via CXCR4.	204
15251986	2004	A small proportion of mesenchymal stem cells strongly expresses functionally active CXCR4 receptor capable of promoting migration to bone marrow.	199
14595012	2003	A small-molecule antagonist of CXCR4 inhibits intracranial growth of primary brain tumors.	190

Citation

Dessen P

CXCR4 (C-X-C motif chemokine receptor 4)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40225/cxcr4-(c-x-c-motif-chemokine-receptor-4)