CXXC4 (CXXC finger protein 4)

2003-05-01  

Identity

HGNC
CXXC4
LOCATION
4q24
LOCUSID
80319
ALIAS
IDAX
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 80319
MIM: 611645
HGNC: 24593
Ensembl: ENSG00000168772

Variants:

dbSNP: 80319
ClinVar: 80319
TCGA: ENSG00000168772
COSMIC: CXXC4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000168772ENST00000394767J9JIF5

Expression (GTEx)

0
1
2
3
4
5
6
7
8
9
10
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Wnt signaling pathwayKEGGko04310
Wnt signaling pathwayKEGGhsa04310
Signal TransductionREACTOMER-HSA-162582
Signaling by WntREACTOMER-HSA-195721
TCF dependent signaling in response to WNTREACTOMER-HSA-201681
Negative regulation of TCF-dependent signaling by DVL-interacting proteinsREACTOMER-HSA-5368598

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA164713176Platinum compoundsChemicalClinicalAnnotationassociatedPD24980784
PA443622Carcinoma, Non-Small-Cell LungDiseaseClinicalAnnotationassociatedPD24980784

References

Pubmed IDYearTitleCitations
340769822021SPZ1 promotes glioma aggravation via targeting CXXC4.2
340769822021SPZ1 promotes glioma aggravation via targeting CXXC4.2
327156412020CXXC finger protein 4 inhibits the CDK18-ERK1/2 axis to suppress the immune escape of gastric cancer cells with involvement of ELK1/MIR100HG pathway.18
331072352020LUCAT1 Epigenetically Downregulates the Tumor Suppressor Genes CXXC4 and SFRP2 in Gastric Cancer.5
332050682020Malignant Transformation Involving CXXC4 Mutations Identified in a Leukemic Progression Model of Severe Congenital Neutropenia.10
327156412020CXXC finger protein 4 inhibits the CDK18-ERK1/2 axis to suppress the immune escape of gastric cancer cells with involvement of ELK1/MIR100HG pathway.18
331072352020LUCAT1 Epigenetically Downregulates the Tumor Suppressor Genes CXXC4 and SFRP2 in Gastric Cancer.5
332050682020Malignant Transformation Involving CXXC4 Mutations Identified in a Leukemic Progression Model of Severe Congenital Neutropenia.10
293370632018BMI1 activates WNT signaling in colon cancer by negatively regulating the WNT antagonist IDAX.14
300421692018MiR-629-5p promotes colorectal cancer progression through targetting CXXC finger protein 4.10
293370632018BMI1 activates WNT signaling in colon cancer by negatively regulating the WNT antagonist IDAX.14
300421692018MiR-629-5p promotes colorectal cancer progression through targetting CXXC finger protein 4.10
250648422014New tumor suppressor CXXC finger protein 4 inactivates mitogen activated protein kinase signaling.10
250850162014CXXC4 mRNA levels are associated with clinicopathological parameters and survival of myelodysplastic syndrome patients.3
250648422014New tumor suppressor CXXC finger protein 4 inactivates mitogen activated protein kinase signaling.10

Citation

Dessen P

CXXC4 (CXXC finger protein 4)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/40226/cxxc4-(cxxc-finger-protein-4)