TET1 (tet methylcytosine dioxygenase 1)

2003-02-01 Affiliation

Identity

HGNC

TET1

LOCATION

10q21.3

LOCUSID

80312

ALIAS

CXXC6,LCX,bA119F7.1

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 80312
MIM: 607790
HGNC: 29484
Ensembl: ENSG00000138336

Variants:

dbSNP: 80312
ClinVar: 80312
TCGA: ENSG00000138336
COSMIC: TET1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000138336	ENST00000373644	Q8NFU7

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Gene Expression	REACTOME	R-HSA-74160
Epigenetic regulation of gene expression	REACTOME	R-HSA-212165
TET1,2,3 and TDG demethylate DNA	REACTOME	R-HSA-5221030

References

Pubmed ID	Year	Title	Citations
19372391	2009	Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1.	1858
21251613	2011	Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases.	828
21496894	2011	Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain.	537
19420352	2009	Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies.	240
19420352	2009	Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies.	240
12646957	2003	TET1, a member of a novel protein family, is fused to MLL in acute myeloid leukemia containing the t(10;11)(q22;q23).	138
23716660	2013	HMGA2/TET1/HOXA9 signaling pathway regulates breast cancer growth and metastasis.	108
22999938	2012	TET1 suppresses cancer invasion by activating the tissue inhibitors of metalloproteinases.	107
22320381	2012	Loss of 5-hydroxymethylcytosine is accompanied with malignant cellular transformation.	97
23818607	2013	TET1 plays an essential oncogenic role in MLL-rearranged leukemia.	74

Citation

Dessen P

TET1 (tet methylcytosine dioxygenase 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40227/tet1-(tet-methylcytosine-dioxygenase-1)