CYP19A1 (cytochrome P450 family 19 subfamily A member 1)

2003-02-01  

Identity

HGNC
CYP19A1
LOCATION
15q21.2
LOCUSID
1588
ALIAS
ARO,ARO1,CPV1,CYAR,CYP19,CYPXIX,P-450AROM
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 1588
MIM: 107910
HGNC: 2594
Ensembl: ENSG00000137869

Variants:

dbSNP: 1588
ClinVar: 1588
TCGA: ENSG00000137869
COSMIC: CYP19A1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000137869ENST00000396402P11511
ENSG00000137869ENST00000396402A0A024R5S8
ENSG00000137869ENST00000396404P11511
ENSG00000137869ENST00000396404A0A024R5S8
ENSG00000137869ENST00000405011E9PGZ6
ENSG00000137869ENST00000405913P11511
ENSG00000137869ENST00000439712E7EQ08
ENSG00000137869ENST00000453807E7EPL6
ENSG00000137869ENST00000557858P11511
ENSG00000137869ENST00000557934E7EQ08
ENSG00000137869ENST00000558328H0YLP1
ENSG00000137869ENST00000559646H0YLS2
ENSG00000137869ENST00000559653H0YK57
ENSG00000137869ENST00000559878P11511
ENSG00000137869ENST00000559878A0A024R5S8
ENSG00000137869ENST00000559980H0YKN1
ENSG00000137869ENST00000561075H0YNJ7
ENSG00000137869ENST00000613097A0A087WVQ0

Expression (GTEx)

0
1
2
3
4
5
6
7
8
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Steroid hormone biosynthesisKEGGko00140
Steroid hormone biosynthesisKEGGhsa00140
Metabolic pathwaysKEGGhsa01100
C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estroneKEGGhsa_M00110
C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estroneKEGGM00110
Ovarian steroidogenesisKEGGhsa04913
Ovarian steroidogenesisKEGGko04913
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Metabolism of steroid hormonesREACTOMER-HSA-196071
Estrogen biosynthesisREACTOMER-HSA-193144
Biological oxidationsREACTOMER-HSA-211859
Phase 1 - Functionalization of compoundsREACTOMER-HSA-211945
Cytochrome P450 - arranged by substrate typeREACTOMER-HSA-211897
Endogenous sterolsREACTOMER-HSA-211976

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA128406956fluorouracilChemicalClinicalAnnotationassociatedPD
PA133950441hmg coa reductase inhibitorsChemicalClinicalAnnotationassociated26463708
PA164712732Enzyme inhibitorsChemicalPathwayassociated19512956
PA166048848MenopauseDiseaseClinicalAnnotation, VariantAnnotationassociatedPD26463708
PA166122986radiotherapyChemicalClinicalAnnotationassociatedPD
PA166129559hdl cholesterolChemicalClinicalAnnotationassociated26463708
PA443560Breast NeoplasmsDiseaseClinicalAnnotation, VariantAnnotationassociatedPD20048079, 24590773, 26463708, 26536870
PA445058Neoplasm MetastasisDiseaseClinicalAnnotationassociatedPD
PA448432anastrozoleChemicalClinicalAnnotation, PathwayassociatedPD20048079
PA448771capecitabineChemicalClinicalAnnotationassociatedPD
PA449165cyclophosphamideChemicalClinicalAnnotationassociatedPD
PA449383docetaxelChemicalClinicalAnnotationassociatedPD
PA449412doxorubicinChemicalClinicalAnnotationassociatedPD
PA449476epirubicinChemicalClinicalAnnotationassociatedPD
PA449563exemestaneChemicalClinicalAnnotation, PathwayassociatedPD20048079, 24590773, 26536870
PA450196letrozoleChemicalClinicalAnnotation, PathwayassociatedPD20048079, 26463708, 26536870
PA450761paclitaxelChemicalClinicalAnnotationassociatedPD
PA451581tamoxifenChemicalClinicalAnnotationassociatedPD
PA451776triglyceridesChemicalClinicalAnnotation, VariantAnnotationassociated26463708

References

Pubmed IDYearTitleCitations
380489182024The relationship between CYP19A1 gene expression in luteinized granulosa cells and follicular estradiol output in women with endometriosis.2
383387202024Charged Amino Acids in the Transmembrane Helix Strongly Affect the Enzyme Activity of Aromatase.0
387035122024Small angle scattering reveals the orientation of cytochrome P450 19A1 in lipoprotein nanodiscs.0
380489182024The relationship between CYP19A1 gene expression in luteinized granulosa cells and follicular estradiol output in women with endometriosis.2
383387202024Charged Amino Acids in the Transmembrane Helix Strongly Affect the Enzyme Activity of Aromatase.0
387035122024Small angle scattering reveals the orientation of cytochrome P450 19A1 in lipoprotein nanodiscs.0
355387942023Evaluation of the Relationship between Aromatase/Sirtuin1 Interaction and miRNA Expression in Human Neuroblastoma Cells.0
355931812023Genetic polymorphisms related to muscular strength and flexibility are associated with artistic gymnastic performance in the Japanese population.2
364414972023Association of CYP19A1 Gene, Plasma Zinc, and Urinary Zinc with the Risk of Type 2 Diabetes Mellitus in a Chinese Population.2
370755682023Association between barium exposed, CYP19A1 and central obesity: A cross-sectional study in rural China.1
375726672023CYP19A1 mediates severe SARS-CoV-2 disease outcome in males.2
377841352023CYP19A1 promotes gastric cancer as part of a lipid metabolism-related gene signature related to the response of immunotherapy and prognosis.0
378204402023Intratumoral cortisol associated with aromatase in the endometrial cancer microenvironment.0
378882992023SNP of Aromatase Predict Long-term Survival and Aromatase Inhibitor Toxicity in Patients with Early Breast Cancer: A Biomarker Analysis of the GIM4 and GIM5 Trials.0
355387942023Evaluation of the Relationship between Aromatase/Sirtuin1 Interaction and miRNA Expression in Human Neuroblastoma Cells.0

Citation

Dessen P

CYP19A1 (cytochrome P450 family 19 subfamily A member 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40234/cyp19a1-(cytochrome-p450-family-19-subfamily-a-member-1)