Identity
HGNC
LOCATION
15q24.1
LOCUSID
ALIAS
AHH,AHRR,CP11,CYP1,CYPIA1,P1-450,P450-C,P450DX
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 1543
MIM: 108330
HGNC: 2595
Ensembl: ENSG00000140465
Variants:
dbSNP: 1543
ClinVar: 1543
TCGA: ENSG00000140465
COSMIC: CYP1A1
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA164760843 | deferasirox | Chemical | ClinicalAnnotation | associated | PK | 25348619, 27193993 | |
| PA166123431 | heart valve replacement | Disease | ClinicalAnnotation | associated | PD | 27740732 | |
| PA443560 | Breast Neoplasms | Disease | ClinicalAnnotation, VariantAnnotation | ambiguous | PK | PD | 22426923 |
| PA444065 | Epilepsy | Disease | ClinicalAnnotation | associated | PK | PD | 21121773, 26951882 |
| PA446432 | beta-Thalassemia | Disease | ClinicalAnnotation | associated | PK | 25348619, 27193993 | |
| PA447215 | Psychotic Disorders | Disease | ClinicalAnnotation | associated | PK | 23492908 | |
| PA448404 | amodiaquine | Chemical | Pathway | associated | |||
| PA448771 | capecitabine | Chemical | ClinicalAnnotation | associated | PD | 22426923 | |
| PA448785 | carbamazepine | Chemical | ClinicalAnnotation | associated | PK | PD | 21121773, 26951882 |
| PA449197 | dacarbazine | Chemical | VariantAnnotation | associated | PK | 27428168 | |
| PA449383 | docetaxel | Chemical | ClinicalAnnotation | associated | PD | 22426923 | |
| PA449563 | exemestane | Chemical | VariantAnnotation | not associated | PK | ||
| PA449809 | granisetron | Chemical | ClinicalAnnotation, VariantAnnotation | associated | PK | 27809336 | |
| PA450688 | olanzapine | Chemical | ClinicalAnnotation | associated | PK | 23492908 | |
| PA450911 | phenobarbital | Chemical | ClinicalAnnotation | associated | PK | PD | 21121773, 26951882 |
| PA450947 | phenytoin | Chemical | ClinicalAnnotation | associated | PK | PD | 21121773, 26951882 |
| PA451846 | valproic acid | Chemical | ClinicalAnnotation | associated | PK | PD | 21121773, 26951882 |
| PA451906 | warfarin | Chemical | ClinicalAnnotation, MultilinkAnnotation | associated | PD | 27740732, 8689941 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36623673 | 2023 | Genic-intergenic polymorphisms of CYP1A genes and their clinical impact. | 1 |
| 36881057 | 2023 | Association Between CYP1A1 Polymorphisms and Esophageal Cancer Susceptibility: A Case-control Study. | 0 |
| 36921208 | 2023 | Assessment of cytochrome P450 1A1 gene polymorphism and vitamin A serum level in psoriasis vulgaris. | 0 |
| 37195087 | 2023 | CYP1A1 common gene polymorphisms and ischemic stroke risk: a meta-analysis and a structural examination. | 0 |
| 37506988 | 2023 | Association of CYP1A1 T3801C (rs4646903) variant with the susceptibility and progression of B-chronic lymphocytic Leukemia (B-CLL) in the Egyptian population. | 0 |
| 37511239 | 2023 | Hydration and Structural Adaptations of the Human CYP1A1, CYP1A2, and CYP1B1 Active Sites by Molecular Dynamics Simulations. | 1 |
| 38376298 | 2023 | Genetic polymorphisms of CYP1A, CYP1B, CYP2C and risk of cervical cancer among rural population of Maharashtra: Findings from a hospital-based case-control study. | 1 |
| 36623673 | 2023 | Genic-intergenic polymorphisms of CYP1A genes and their clinical impact. | 1 |
| 36881057 | 2023 | Association Between CYP1A1 Polymorphisms and Esophageal Cancer Susceptibility: A Case-control Study. | 0 |
| 36921208 | 2023 | Assessment of cytochrome P450 1A1 gene polymorphism and vitamin A serum level in psoriasis vulgaris. | 0 |
| 37195087 | 2023 | CYP1A1 common gene polymorphisms and ischemic stroke risk: a meta-analysis and a structural examination. | 0 |
| 37506988 | 2023 | Association of CYP1A1 T3801C (rs4646903) variant with the susceptibility and progression of B-chronic lymphocytic Leukemia (B-CLL) in the Egyptian population. | 0 |
| 37511239 | 2023 | Hydration and Structural Adaptations of the Human CYP1A1, CYP1A2, and CYP1B1 Active Sites by Molecular Dynamics Simulations. | 1 |
| 38376298 | 2023 | Genetic polymorphisms of CYP1A, CYP1B, CYP2C and risk of cervical cancer among rural population of Maharashtra: Findings from a hospital-based case-control study. | 1 |
| 35380334 | 2022 | Contribution of CYP19A1, CYP1A1, and CYP1A2 polymorphisms in coronary heart disease risk among the Chinese Han population. | 0 |
Citation
Dessen P
CYP1A1 (cytochrome P450 family 1 subfamily A member 1)
Atlas Genet Cytogenet Oncol Haematol. 2003-02-01
Online version: http://atlasgeneticsoncology.org/gene/40235/cyp1a1-(cytochrome-p450-family-1-subfamily-a-member-1)
