CYP2C18 (cytochrome P450 family 2 subfamily C member 18)

2003-08-01 Affiliation

Identity

HGNC

CYP2C18

LOCATION

10q23.33

LOCUSID

1562

ALIAS

CPCI,CYP2C,CYP2C17,P450-6B/29C,P450IIC17

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 1562
MIM: 601131
HGNC: 2620
Ensembl: ENSG00000108242

Variants:

dbSNP: 1562
ClinVar: 1562
TCGA: ENSG00000108242
COSMIC: CYP2C18

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000108242	ENST00000285979	P33260
ENSG00000108242	ENST00000339022	P33260

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Retinol metabolism	KEGG	ko00830
Retinol metabolism	KEGG	hsa00830
Metabolic pathways	KEGG	hsa01100
Serotonergic synapse	KEGG	hsa04726
Chemical carcinogenesis	KEGG	hsa05204
Chemical carcinogenesis	KEGG	ko05204
Metabolism	REACTOME	R-HSA-1430728
Biological oxidations	REACTOME	R-HSA-211859
Phase 1 - Functionalization of compounds	REACTOME	R-HSA-211945
Cytochrome P450 - arranged by substrate type	REACTOME	R-HSA-211897
Xenobiotics	REACTOME	R-HSA-211981

References

Pubmed ID	Year	Title	Citations
19706858	2009	Association of cytochrome P450 2C19 genotype with the antiplatelet effect and clinical efficacy of clopidogrel therapy.	307
17048007	2007	Association of warfarin dose with genes involved in its action and metabolism.	100
16385451	2006	A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.	69
19204726	2009	Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease.	63
19578179	2009	A genome-wide association study of acenocoumarol maintenance dosage.	50
19074885	2008	Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia.	25
19958090	2009	Genetic determinants of warfarin dosing in the Han-Chinese population.	25
20453000	2010	A Large-scale genetic association study of esophageal adenocarcinoma risk.	23
20529763	2010	Evaluation of candidate genes for cholinesterase activity in farmworkers exposed to organophosphorus pesticides: association of single nucleotide polymorphisms in BCHE.	8
19751749	2009	Risk of malignant pleural mesothelioma and polymorphisms in genes involved in the genome stability and xenobiotics metabolism.	7

Citation

Dessen P

CYP2C18 (cytochrome P450 family 2 subfamily C member 18)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/40242/cyp2c18-(cytochrome-p450-family-2-subfamily-c-member-18)