CYP2C18 (cytochrome P450 family 2 subfamily C member 18)

2003-08-01  

Identity

HGNC
CYP2C18
LOCATION
10q23.33
LOCUSID
1562
ALIAS
CPCI,CYP2C,CYP2C17,P450-6B/29C,P450IIC17
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 1562
MIM: 601131
HGNC: 2620
Ensembl: ENSG00000108242

Variants:

dbSNP: 1562
ClinVar: 1562
TCGA: ENSG00000108242
COSMIC: CYP2C18

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000108242ENST00000285979P33260
ENSG00000108242ENST00000339022P33260

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Retinol metabolismKEGGko00830
Retinol metabolismKEGGhsa00830
Metabolic pathwaysKEGGhsa01100
Serotonergic synapseKEGGhsa04726
Chemical carcinogenesisKEGGhsa05204
Chemical carcinogenesisKEGGko05204
MetabolismREACTOMER-HSA-1430728
Biological oxidationsREACTOMER-HSA-211859
Phase 1 - Functionalization of compoundsREACTOMER-HSA-211945
Cytochrome P450 - arranged by substrate typeREACTOMER-HSA-211897
XenobioticsREACTOMER-HSA-211981

References

Pubmed IDYearTitleCitations
337591772021A Novel CYP2C-Haplotype Associated With Ultrarapid Metabolism of Escitalopram.16
337591772021A Novel CYP2C-Haplotype Associated With Ultrarapid Metabolism of Escitalopram.16
217988612011Genetic variation in the CYP2C monooxygenase enzyme subfamily shows no association with longevity in a German population.1
217988612011Genetic variation in the CYP2C monooxygenase enzyme subfamily shows no association with longevity in a German population.1
204530002010A Large-scale genetic association study of esophageal adenocarcinoma risk.26
205297632010Evaluation of candidate genes for cholinesterase activity in farmworkers exposed to organophosphorus pesticides: association of single nucleotide polymorphisms in BCHE.8
204530002010A Large-scale genetic association study of esophageal adenocarcinoma risk.26
205297632010Evaluation of candidate genes for cholinesterase activity in farmworkers exposed to organophosphorus pesticides: association of single nucleotide polymorphisms in BCHE.8
192047262009Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease.93
192907872009Novel DNA sequence variations of cytochrome P450 genes in the Han Chinese population.2
195781792009A genome-wide association study of acenocoumarol maintenance dosage.54
197068582009Association of cytochrome P450 2C19 genotype with the antiplatelet effect and clinical efficacy of clopidogrel therapy.413
197517492009Risk of malignant pleural mesothelioma and polymorphisms in genes involved in the genome stability and xenobiotics metabolism.9
199580902009Genetic determinants of warfarin dosing in the Han-Chinese population.25
200459892009Influence of the genetic polymorphisms in the 5' flanking and exonic regions of CYP2C19 on proguanil oxidation.4

Citation

Dessen P

CYP2C18 (cytochrome P450 family 2 subfamily C member 18)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/40242/cyp2c18-(cytochrome-p450-family-2-subfamily-c-member-18)