CYP2C9 (cytochrome P450 family 2 subfamily C member 9)

2003-08-01 Affiliation

Identity

HGNC

CYP2C9

LOCATION

10q23.33

LOCUSID

1559

ALIAS

CPC9,CYP2C,CYP2C10,CYPIIC9,P450IIC9

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 1559
MIM: 601130
HGNC: 2623
Ensembl: ENSG00000138109

Variants:

dbSNP: 1559
ClinVar: 1559
TCGA: ENSG00000138109
COSMIC: CYP2C9

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000138109	ENST00000260682	P11712
ENSG00000138109	ENST00000260682	S5RV20
ENSG00000138109	ENST00000461906	P11712
ENSG00000138109	ENST00000643112	A0A2R8YF67

Expression (GTEx)

100

150

200

250

300

350

400

450

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Arachidonic acid metabolism	KEGG	ko00590
Linoleic acid metabolism	KEGG	ko00591
Retinol metabolism	KEGG	ko00830
Metabolism of xenobiotics by cytochrome P450	KEGG	ko00980
Drug metabolism - cytochrome P450	KEGG	ko00982
Arachidonic acid metabolism	KEGG	hsa00590
Linoleic acid metabolism	KEGG	hsa00591
Retinol metabolism	KEGG	hsa00830
Metabolism of xenobiotics by cytochrome P450	KEGG	hsa00980
Drug metabolism - cytochrome P450	KEGG	hsa00982
Metabolic pathways	KEGG	hsa01100
Serotonergic synapse	KEGG	hsa04726
Chemical carcinogenesis	KEGG	hsa05204
Chemical carcinogenesis	KEGG	ko05204
Metabolism	REACTOME	R-HSA-1430728
Metabolism of lipids and lipoproteins	REACTOME	R-HSA-556833
Arachidonic acid metabolism	REACTOME	R-HSA-2142753
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)	REACTOME	R-HSA-2142816
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)	REACTOME	R-HSA-2142670
Biological oxidations	REACTOME	R-HSA-211859
Phase 1 - Functionalization of compounds	REACTOME	R-HSA-211945
Cytochrome P450 - arranged by substrate type	REACTOME	R-HSA-211897
Xenobiotics	REACTOME	R-HSA-211981
CYP2E1 reactions	REACTOME	R-HSA-211999

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA10034	bosentan	Chemical	VariantAnnotation	ambiguous	PK	PD	24048276, 24842639
PA10075	esomeprazole	Chemical	LabelAnnotation	associated
PA10233	voriconazole	Chemical	LabelAnnotation, VariantAnnotation	ambiguous	PK		26886310
PA10390	sulfonamides, urea derivatives	Chemical	ClinicalAnnotation	associated		PD	19794412, 24442125, 29681852
PA10892	gliclazide	Chemical	GuidelineAnnotation, VariantAnnotation	associated			24442125
PA124	CYP2C19	Gene	DataAnnotation	associated
PA131301952	gefitinib	Chemical	Literature, MultilinkAnnotation	associated			24433361
PA131890625	tenoxicam	Chemical	ClinicalAnnotation, GuidelineAnnotation, VariantAnnotation	associated	PK		15229460, 18992346
PA133787052	VKORC1	Gene	DataAnnotation, VipGene	associated			12931134, 14765194, 14765195, 15358623, 15597574, 15865594, 15930419, 15938684, 16888441, 16960144, 16983400, 17124101, 9684798, 11926893
PA133950441	hmg coa reductase inhibitors	Chemical	Pathway	associated
PA134308647	rosuvastatin	Chemical	VariantAnnotation	not associated	PK		23930675
PA134852920	benzbromarone	Chemical	MultilinkAnnotation, VariantAnnotation	associated	PK		20962433, 25876828
PA143485705	antiepileptics	Chemical	VariantAnnotation	associated		PD
PA154410481	prasugrel	Chemical	LabelAnnotation	associated
PA162316739	Maculopapular Exanthema	Disease	ClinicalAnnotation, VariantAnnotation	ambiguous		PD	20941486, 25096692
PA164712462	Antiinflammatory agents, non-steroids	Chemical	ClinicalAnnotation	associated		PD	17681167
PA164744895	gliquidone	Chemical	VariantAnnotation	associated			24442125
PA164746757	tolterodine	Chemical	LabelAnnotation	associated
PA164784021	ethambutol	Chemical	ClinicalAnnotation	associated		PD	20941486
PA165108401	Acute coronary syndrome	Disease	ClinicalAnnotation	associated	PK	PD	17900275, 19463375, 19934793, 20833683, 21831410, 22990067, 27756942
PA165111675	Drug Resistance	Disease	VariantAnnotation	associated		PD
PA165816542	CYP2C9*1	Haplotype	LabelAnnotation	associated
PA165816543	CYP2C9*2	Haplotype	GuidelineAnnotation, LabelAnnotation, VipGene	associated			11927841, 14597963, 15469410, 15637526, 16863464, 19151603, 8004131, 9241660, 11337938
PA165816544	CYP2C9*3	Haplotype	GuidelineAnnotation, LabelAnnotation, VipGene	associated			11927841, 12698304, 14597963, 15289789, 15637526, 19082874, 10761997
PA165816546	CYP2C9*5	Haplotype	GuidelineAnnotation	associated
PA165816547	CYP2C9*6	Haplotype	GuidelineAnnotation	associated
PA165816549	CYP2C9*8	Haplotype	GuidelineAnnotation	associated
PA165816552	CYP2C9*11	Haplotype	GuidelineAnnotation	associated
PA165954769	HLA-B*15:02:01	Haplotype	LabelAnnotation	associated
PA165958395	lornoxicam	Chemical	ClinicalAnnotation, GuidelineAnnotation, VariantAnnotation, VipGene	associated	PK		15764711, 16182270, 16342679
PA165980614	fluindione	Chemical	GuidelineAnnotation, VariantAnnotation	ambiguous	PK
PA166119041	drug-induced liver injury	Disease	VariantAnnotation	ambiguous		PD	24842639
PA166120927	drug reaction with eosinophilia and systemic symptoms	Disease	VariantAnnotation	ambiguous		PD	25096692, 29458119
PA166120929	severe cutaneous adverse reactions	Disease	VariantAnnotation	associated		PD	25994870
PA166122646	hemopoietic stem cell transplant	Disease	ClinicalAnnotation	associated	PK		24165757
PA166123298	over-anticoagulation	Disease	VariantAnnotation	ambiguous		PD	11692083, 11926893, 12414349, 12634980, 14614357, 15001971, 15116052, 15128048, 15536456, 16815313, 17226852, 17324110, 17989110, 18690342, 18781852, 19225451, 19794411, 20354686, 21318593, 22252093, 22571356, 22990331, 23016521, 23104259, 23279643, 23602689, 24911077, 24919870, 24956252, 25769357
PA166123431	heart valve replacement	Disease	ClinicalAnnotation, VariantAnnotation	associated		PD	11926893, 17324110, 17955230, 18322281, 18690342, 19077919, 23279643, 24474498, 25504915, 29396738
PA166123766	platelet aggregation	Disease	VariantAnnotation	ambiguous		PD	28745576
PA166124478	endoxifen	Chemical	VariantAnnotation	not associated	PK		15632378, 29436156
PA166127651	n-desmethyltamoxifen	Chemical	VariantAnnotation	not associated	PK		29436156
PA166127652	4-hydroxytamoxifen	Chemical	VariantAnnotation	ambiguous	PK		29436156
PA166129530	time to achieve stable dose	Disease	VariantAnnotation	ambiguous		PD	11926893, 15116052, 16815313, 17324110, 17955230, 18690342, 21057703, 23279643, 24956252
PA166129531	time in therapeutic range	Disease	VariantAnnotation	ambiguous		PD	10961881, 12414349, 17226852, 17955230, 18690342, 26469104, 27511999
PA166129532	time to therapeutic inr	Disease	VariantAnnotation	ambiguous		PD	11926893, 17226852, 19794411, 20339978, 20386359, 20833980, 21148049, 21318593, 22571356, 23279643, 29396738
PA166129534	time above therapeutic range	Disease	VariantAnnotation	associated		PD	26469104
PA166129560	major adverse cardiac events (mace)	Disease	VariantAnnotation	not associated		PD	28745576
PA166129562	time below therapeutic range	Disease	VariantAnnotation	associated		PD	23016521
PA166131388	4-hydroxycyclophosphamide	Chemical	VipGene	associated			18496131, 12684728
PA166151827	adverse events	Disease	VariantAnnotation	not associated		PD
PA166153431	flibanserin	Chemical	LabelAnnotation	associated
PA166153491	brivaracetam	Chemical	LabelAnnotation	associated
PA166153959	rs1057910	Variant	VipGene	associated			11927841, 12698304, 14597963, 15289789, 15637526, 19082874, 10761997
PA166153972	rs1799853	Variant	VipGene	associated			11927841, 14597963, 15469410, 15637526, 16863464, 19151603, 8004131, 9241660, 11337938
PA166154157	rs12777823	Variant	GuidelineAnnotation	associated
PA166155091	rs9923231	Variant	GuidelineAnnotation, LabelAnnotation	associated
PA166155096	rs9934438	Variant	GuidelineAnnotation	associated
PA166155381	rs2108622	Variant	GuidelineAnnotation	associated
PA166160006	lesinurad	Chemical	LabelAnnotation	associated
PA166163418	rucaparib	Chemical	LabelAnnotation	associated
PA166179849	avatrombopag	Chemical	LabelAnnotation	associated
PA166182720	erdafitinib	Chemical	LabelAnnotation	associated
PA166182736	siponimod	Chemical	GuidelineAnnotation, LabelAnnotation	associated
PA166182883	ospemifene	Chemical	LabelAnnotation	associated
PA27121	CYP4F2	Gene	DataAnnotation	associated
PA28660	GGCX	Gene	DataAnnotation	associated
PA443309	Alcoholism	Disease	VariantAnnotation	associated
PA443459	Atrial Fibrillation	Disease	ClinicalAnnotation, VariantAnnotation	ambiguous	PK	PD	11926893, 15094935, 15970795, 17324110, 17955230, 18322281, 18690342, 19077919, 19387626, 20072124, 21590310, 21635147, 21981797, 22040439, 22534826, 22676192, 23113310, 23279643, 24108193, 24251363, 24474498, 25089947, 25504915, 25769357, 27121899, 29396738, 29479633, 29986700
PA443460	Atrial Flutter	Disease	VariantAnnotation	associated		PD	29479633
PA443523	Blood Coagulation Disorders	Disease	ClinicalAnnotation, VariantAnnotation	associated	PK	PD	11692083, 12414349, 12634980, 14614357, 15116052, 15128048, 16815313, 18781852, 19225451, 22252093, 23651023, 24911077, 24919870, 24956252, 29479633
PA443560	Breast Neoplasms	Disease	VariantAnnotation	ambiguous	PK	PD	15632378, 18024866, 29436156
PA443635	Cardiovascular Diseases	Disease	ClinicalAnnotation, VariantAnnotation	associated	PK	PD	10509530, 11926893, 12496751, 12621390, 14656880, 15001971, 15094935, 15590403, 15841315, 15883587, 15947090, 16493479, 16890578, 17049586, 17391071, 17510308, 17851566, 17989110, 18756910, 18836275, 19031075, 19077919, 19135231, 19177029, 19582440, 19745563, 20421126, 21174619, 21185752, 21326313, 21590310, 21782804, 21981797, 22010099, 22040439, 22075505, 22349464, 22528326, 22534826, 22549502, 22594507, 22676192, 22854539, 22855348, 22892446, 22990331, 23061746, 23104259, 23183958, 23208322, 23279643, 23949431, 24029542, 24474498, 25042728, 25084205, 26517138, 29298995, 31395958, 31653973
PA443636	Carotid Artery Diseases	Disease	VariantAnnotation	not associated		PD	26526111
PA443796	Coronary Artery Disease	Disease	ClinicalAnnotation	associated	PK	PD	17900275, 19463375, 19934793, 20833683, 21831410, 22990067, 27756942
PA443886	Diabetes Mellitus	Disease	VariantAnnotation	associated			24442125
PA443890	Diabetes Mellitus, Type 2	Disease	ClinicalAnnotation	associated		PD	19794412, 24442125, 29681852
PA443937	Drug Toxicity	Disease	ClinicalAnnotation, VariantAnnotation	associated	PK	PD	22641027, 26658169
PA444059	Epidermal Necrolysis, Toxic	Disease	VariantAnnotation	associated		PD	25096692, 26928377
PA444065	Epilepsy	Disease	ClinicalAnnotation, VariantAnnotation	ambiguous	PK	PD	10774639, 10901705, 11434505, 11668218, 11673755, 12707459, 14659971, 15024534, 15385837, 16815679, 19030785, 20390258, 21068649, 21338443, 21532277, 21537551, 22641027, 25096692, 25162219, 25597548, 25994870, 25998968, 26122019, 26928377, 27163851, 9333104, 9860067
PA444250	Gastritis	Disease	VariantAnnotation	associated		PD	26517138
PA444368	Heart Diseases	Disease	ClinicalAnnotation, VariantAnnotation	associated	PK	PD	10509530, 11926893, 12496751, 12621390, 14656880, 15001971, 15094935, 15590403, 15841315, 15883587, 15947090, 16493479, 16890578, 17049586, 17391071, 17510308, 17851566, 17989110, 18756910, 18836275, 19031075, 19077919, 19135231, 19177029, 19582440, 19745563, 20421126, 21174619, 21185752, 21326313, 21590310, 21782804, 21981797, 22010099, 22040439, 22075505, 22349464, 22528326, 22534826, 22549502, 22594507, 22676192, 22854539, 22855348, 22892446, 22990331, 23061746, 23104259, 23183958, 23208322, 23279643, 23949431, 24029542, 24474498, 25042728, 25084205, 29298995, 31395958, 31653973
PA444398	Hematoma, Subdural	Disease	VariantAnnotation	associated		PD
PA444417	Hemorrhage	Disease	ClinicalAnnotation, MultilinkAnnotation, VariantAnnotation	ambiguous		PD	10509530, 11926893, 12414349, 12728288, 12876643, 14676821, 15213846, 15714076, 16699986, 17653141, 17955230, 18570163, 18574025, 18690342, 18752379, 18756910, 18950464, 19297219, 21148049, 22571356, 23104259, 23113310, 23348161, 23602689, 23774101, 23932037, 24474498, 24503627, 24602049, 25001883, 25244877, 25521356, 25585969, 25769357, 25858232, 26777610, 27488176, 27581200, 28033245, 28689179, 29432897, 29577257
PA444516	Hypercholesterolemia	Disease	VariantAnnotation	not associated	PK		23930675
PA444552	Hypertension	Disease	VariantAnnotation	ambiguous		PD	18971529
PA444555	Hypertension, Pulmonary	Disease	VariantAnnotation	not associated		PD	24842639
PA444570	Hypoglycemia	Disease	VariantAnnotation	associated			24442125
PA444584	Hypotension	Disease	ClinicalAnnotation, VariantAnnotation	associated		PD	23559402
PA444682	Kidney Diseases	Disease	VariantAnnotation	associated		PD
PA444773	Leukopenia	Disease	VariantAnnotation	associated		PD	26894931
PA445019	Myocardial Infarction	Disease	VariantAnnotation	not associated		PD
PA445043	Opioid-Related Disorders	Disease	VariantAnnotation	not associated	PK		17178267
PA445062	Neoplasms	Disease	VariantAnnotation	ambiguous		PD	17226852
PA445208	Pain	Disease	VariantAnnotation	associated		PD
PA445465	Pulmonary Embolism	Disease	ClinicalAnnotation, VariantAnnotation	associated	PK	PD	15094935, 15970795, 19387626, 20072124, 21590310, 21635147, 22676192, 27121899, 29986700
PA445506	Recurrence	Disease	VariantAnnotation	not associated		PD	18024866
PA445553	Rheumatic Heart Disease	Disease	VariantAnnotation	associated		PD	27335128
PA445676	Skin Diseases	Disease	VariantAnnotation	not associated		PD	29458119
PA445738	Stevens-Johnson Syndrome	Disease	VariantAnnotation	associated		PD	25096692, 26928377
PA445848	Thromboembolism	Disease	VariantAnnotation	associated	PK	PD	22528326
PA445862	Thyrotoxicosis	Disease	VariantAnnotation	associated		PD
PA445941	Tuberculosis	Disease	ClinicalAnnotation	associated		PD	20941486
PA446023	Vasculitis	Disease	VariantAnnotation	associated		PD	26894931
PA446065	Wegener Granulomatosis	Disease	VariantAnnotation	associated		PD	26894931
PA446813	Gingival Overgrowth	Disease	VariantAnnotation	not associated		PD	14659971
PA446969	Venous Thrombosis	Disease	ClinicalAnnotation, VariantAnnotation	associated	PK	PD	15094935, 15970795, 19387626, 20072124, 21590310, 21635147, 22676192, 27121899, 29479633, 29986700
PA447054	Stroke	Disease	ClinicalAnnotation, VariantAnnotation	ambiguous	PK	PD	15094935, 15970795, 19387626, 20072124, 21590310, 21635147, 22676192, 25989350, 27121899, 29986700
PA447199	Bipolar Disorder	Disease	ClinicalAnnotation, VariantAnnotation	ambiguous	PK	PD	27353638
PA447207	Depressive Disorder	Disease	VariantAnnotation	not associated		PD	24663076
PA447208	Mental Disorders	Disease	VariantAnnotation	ambiguous	PK		14726986, 18677622
PA447215	Psychotic Disorders	Disease	ClinicalAnnotation, VariantAnnotation	ambiguous	PK	PD	27353638
PA447216	Schizophrenia	Disease	VariantAnnotation	not associated	PK		15260906
PA447230	HIV	Disease	VariantAnnotation	associated		PD	11186133
PA447276	Thrombosis of cerebral veins	Disease	VariantAnnotation	associated		PD	24530212
PA447288	Essential hypertension	Disease	ClinicalAnnotation	associated	PK	PD	16094537, 21842338
PA447298	venous thromboembolism	Disease	VariantAnnotation	associated		PD	20421126, 24251363, 25089947
PA447321	Depressive Disorder, Major	Disease	VariantAnnotation	ambiguous	PK		16236141
PA448497	aspirin	Chemical	VariantAnnotation	associated		PD	20833683, 26517138
PA448500	atorvastatin	Chemical	Pathway	associated
PA448691	busulfan	Chemical	ClinicalAnnotation, VariantAnnotation	associated	PK		24165757
PA448817	carvedilol	Chemical	LabelAnnotation, VariantAnnotation	ambiguous	PK		21599570
PA448871	celecoxib	Chemical	ClinicalAnnotation, GuidelineAnnotation, LabelAnnotation, Pathway, VariantAnnotation, VipGene	associated	PK	PD	11337938, 12893985, 16153401, 16401468, 17681167, 22336956, 23996211, 25585969, 26360837, 27864660
PA449053	clopidogrel	Chemical	ClinicalAnnotation, Pathway, VariantAnnotation	ambiguous	PK	PD	17900275, 19463375, 19934793, 20833683, 20938371, 21831410, 22929815, 22990067, 24262617, 26526111, 27756942, 28745576
PA449165	cyclophosphamide	Chemical	VariantAnnotation, VipGene	associated		PD	18496131, 12684728, 26894931
PA449211	dapsone	Chemical	VariantAnnotation	not associated		PD	29458119
PA449283	diazepam	Chemical	VariantAnnotation	associated	PK	PD	22641027
PA449293	diclofenac	Chemical	ClinicalAnnotation, VariantAnnotation, VipGene	associated	PK	PD	17681167, 20814155, 23400009, 23959274, 25994031, 8417277
PA449409	doxepin	Chemical	ClinicalAnnotation, Pathway, VariantAnnotation	associated	PK	PD	12360109
PA449421	dronabinol	Chemical	LabelAnnotation	associated
PA449653	fluconazole	Chemical	VariantAnnotation	associated	PK		26886310
PA449673	fluoxetine	Chemical	Pathway, VariantAnnotation	ambiguous	PK	PD	14726986, 16236141, 24663076
PA449683	flurbiprofen	Chemical	ClinicalAnnotation, GuidelineAnnotation, LabelAnnotation, VariantAnnotation	associated	PK		12698304, 25712887, 32423989
PA449688	fluvastatin	Chemical	ClinicalAnnotation, Pathway, VariantAnnotation, VipGene	ambiguous	PK	PD	12891229, 17289397, 30363031, 7586933
PA449761	glimepiride	Chemical	GuidelineAnnotation, VariantAnnotation, VipGene	associated			16325295, 12235454, 24442125
PA449762	glipizide	Chemical	VariantAnnotation, VipGene	associated			10208645, 24442125
PA449782	glibenclamide	Chemical	GuidelineAnnotation, VariantAnnotation, VipGene	associated			16342679, 24442125
PA449957	ibuprofen	Chemical	ClinicalAnnotation, GuidelineAnnotation, Pathway, VariantAnnotation	ambiguous	PK	PD	12152005, 15289789, 18694831, 19480553, 25502615, 26122864
PA449982	indomethacin	Chemical	ClinicalAnnotation, VariantAnnotation	associated		PD	12876643
PA450084	irbesartan	Chemical	ClinicalAnnotation, MultilinkAnnotation	associated	PK	PD	12359989, 16094537, 21842338
PA450112	isoniazid	Chemical	ClinicalAnnotation	associated		PD	20941486
PA450268	losartan	Chemical	ClinicalAnnotation, LabelAnnotation, Literature, MultilinkAnnotation, Pathway, VariantAnnotation, VipGene	ambiguous	PK	PD	10096267, 11408373, 11823761, 15197523, 15289788, 18971529, 22294058, 22735459, 25303293, 25994031
PA450272	lovastatin	Chemical	Pathway	associated
PA450353	meloxicam	Chemical	ClinicalAnnotation, GuidelineAnnotation, LabelAnnotation, VariantAnnotation, VipGene	associated	PK		24322170, 24615047, 9493314
PA450401	methadone	Chemical	VariantAnnotation	not associated	PK		17178267
PA450595	naproxen	Chemical	ClinicalAnnotation, VariantAnnotation, VipGene	ambiguous	PK		17686967, 19280158, 32423989, 8866821
PA450600	nateglinide	Chemical	Pathway, VariantAnnotation	associated	PK		22842957
PA450616	nevirapine	Chemical	Pathway	associated
PA450688	olanzapine	Chemical	ClinicalAnnotation, VariantAnnotation	associated		PD	23559402
PA450921	phenprocoumon	Chemical	ClinicalAnnotation, DataAnnotation, GuidelineAnnotation, VariantAnnotation	ambiguous	PK	PD	12728288, 15128047, 15128048, 15213846, 15536456, 15742978, 16847664, 18629445, 19319511, 20020283, 20376629, 20833980, 21057703, 21063236, 23016521, 23423913, 24224579, 26984978, 30207196
PA450947	phenytoin	Chemical	ClinicalAnnotation, DataAnnotation, GuidelineAnnotation, LabelAnnotation, Literature, MultilinkAnnotation, Pathway, VariantAnnotation, VipGene	ambiguous	PK	PD	10208645, 10774639, 10901705, 11434505, 11668218, 11673755, 12707459, 14659971, 15024534, 15385837, 16220110, 16815679, 19030785, 20390258, 21068649, 21338443, 21532277, 21537551, 22569204, 22641027, 25096692, 25099164, 25162219, 25597548, 25994870, 25998968, 26122019, 26658169, 26928377, 27163851, 32423989, 9333104, 9860067
PA450970	pioglitazone	Chemical	VariantAnnotation	associated	PK		28099407
PA450985	piroxicam	Chemical	ClinicalAnnotation, GuidelineAnnotation, LabelAnnotation, VariantAnnotation	associated	PK	PD	16198655, 17112811
PA451141	propofol	Chemical	VariantAnnotation	associated	PK		24891132
PA451182	pyrazinamide	Chemical	ClinicalAnnotation	associated		PD	20941486
PA451250	rifampin	Chemical	ClinicalAnnotation	associated		PD	20941486
PA451257	risperidone	Chemical	VariantAnnotation	not associated	PK		15260906
PA451283	rosiglitazone	Chemical	Pathway	associated
PA451333	sertraline	Chemical	VariantAnnotation	not associated	PK		18677622
PA451363	simvastatin	Chemical	ClinicalAnnotation, Pathway, VariantAnnotation	ambiguous	PK	PD	17289397, 22594507
PA451544	sulfamethoxazole	Chemical	VariantAnnotation	associated		PD	11186133
PA451581	tamoxifen	Chemical	Pathway, VariantAnnotation, VipGene	ambiguous	PK	PD	15632378, 18024866, 23962908, 29436156
PA451718	tolbutamide	Chemical	ClinicalAnnotation, GuidelineAnnotation, VariantAnnotation, VipGene	associated	PK		11875364, 15284535, 25994031, 27339126, 8742240
PA451791	trimipramine	Chemical	ClinicalAnnotation, VariantAnnotation	associated	PK		14520122
PA451846	valproic acid	Chemical	ClinicalAnnotation, VariantAnnotation	ambiguous	PK	PD	14597963, 27353638
PA451906	warfarin	Chemical	ClinicalAnnotation, DataAnnotation, GuidelineAnnotation, LabelAnnotation, Literature, MultilinkAnnotation, VariantAnnotation, VipGene	ambiguous	PK	PD	8004131, 8747411, 8801057, 10073515, 10509530, 10961881, 11127854, 11926893, 12414349, 12496751, 12621390, 12634980, 12876643, 14521618, 14656880, 14676821, 15001971, 15094935, 15213846, 15590403, 15714076, 1581537, 15841315, 15883587, 15947090, 15970795, 16432637, 16493479, 16699986, 16863464, 16890578, 16983400, 17015052, 17049586, 17111199, 17226852, 17289397, 17324110, 17387222, 17391071, 17510308, 17653141, 17851566, 17955230, 17989110, 18030307, 18183038, 18305455, 18322281, 18466099, 18535201, 18542936, 18570163, 18574025, 18690342, 18698879, 18752379, 18756910, 18836275, 18950464, 19031075, 19074728, 19077919, 19135231, 19177029, 19228618, 19297219, 19300499, 19387626, 19582440, 19745563, 19752777, 19794411, 20072124, 20339191, 20339978, 20354686, 20386359, 20410877, 20421126, 20585834, 20833655, 20833980, 21110192, 21148049, 21174619, 21185752, 21228733, 21318593, 21326313, 21383771, 21590310, 21635147, 21725053, 21782804, 21900891, 21981797, 22010099, 22040439, 22075505, 22130800, 22248286, 22349464, 22528326, 22534826, 22549502, 22571356, 22594507, 22676192, 22854539, 22855348, 22892446, 22990331, 23061746, 23104259, 23113310, 23159229, 23183958, 23208322, 23279643, 23348161, 23582453, 23602689, 23688605, 23774101, 23932037, 23941071, 23949431, 24019055, 24029542, 24088130, 24251363, 24330000, 24474498, 24503627, 24602049, 24728385, 24911077, 25001883, 25026456, 25042728, 25075423, 25084205, 25126975, 25244877, 25312789, 25504915, 25521356, 25594941, 25712185, 25769357, 25858232, 25989350, 25994031, 26010205, 26219158, 26223945, 26257249, 26469104, 26777610, 27121899, 27488176, 27488389, 27511999, 27581200, 27617219, 27661060, 27878474, 28033245, 28049362, 28262345, 28429387, 28550460, 28689179, 28973620, 29054760, 29298995, 29396738, 29432897, 29577257, 29986700, 30821933, 31395958, 31653973, 32423989, 8004131, 9630825
PA451949	zafirlukast	Chemical	ClinicalAnnotation, VariantAnnotation	associated	PK		27377818
PA451954	zidovudine	Chemical	Pathway	associated			22960662
PA452632	acenocoumarol	Chemical	ClinicalAnnotation, DataAnnotation, GuidelineAnnotation, LabelAnnotation, Literature, MultilinkAnnotation, VariantAnnotation	ambiguous	PK	PD	10509530, 11186138, 11557918, 11692083, 11926893, 12010835, 12123234, 12414349, 12634980, 12844136, 12876643, 14521618, 14614357, 14676821, 15116052, 15116053, 15128048, 15213846, 15714076, 15790782, 16699986, 16815313, 16863464, 17653141, 17955230, 18021343, 18570163, 18574025, 18690342, 18756910, 18781852, 18950464, 19018719, 19225451, 19277427, 19297219, 19578179, 20020283, 21148049, 21811894, 22252093, 22486182, 22571356, 22629463, 22911785, 22920394, 23104259, 23113310, 23159639, 23348161, 23473641, 23481074, 23582453, 23602689, 23651023, 23774101, 23774941, 23932037, 24108193, 24474498, 24503627, 24530212, 24602049, 24911077, 24919870, 24956252, 25001883, 25042728, 25089947, 25244877, 25519826, 25521356, 25769357, 25858232, 26777610, 26781925, 27335128, 27488176, 27581200, 28033245, 28689179, 29432897, 29479633, 29577257, 30983536
PA452637	hormonal contraceptives for systemic use	Chemical	ClinicalAnnotation	associated		PD	28750087
PA55	APOE	Gene	DataAnnotation	associated
PA7000	sorafenib	Chemical	Pathway	associated			28362716

References

Pubmed ID	Year	Title	Citations
37747773	2024	Identification of the effects of pathogenic genetic variations of human CYP2C9 and CYP2D6: an in silico approach.	0
37875597	2024	Association of variants in the ABCB1, CYP2C19 and CYP2C9 genes for Juvenile Myoclonic Epilepsy.	0
38227154	2024	Genetic variation of CYP2C9 gene and its correlation with cardiovascular disease risk factors.	0
37747773	2024	Identification of the effects of pathogenic genetic variations of human CYP2C9 and CYP2D6: an in silico approach.	0
37875597	2024	Association of variants in the ABCB1, CYP2C19 and CYP2C9 genes for Juvenile Myoclonic Epilepsy.	0
38227154	2024	Genetic variation of CYP2C9 gene and its correlation with cardiovascular disease risk factors.	0
36601711	2023	Dosage exploration of meloxicam according to CYP2C9 genetic polymorphisms based on a population pharmacokinetic-pharmacodynamic model.	1
36651185	2023	Biotransformation of Bisphenol by Human Cytochrome P450 2C9 Enzymes: A Density Functional Theory Study.	4
36718958	2023	Effects of UGT1A, CYP2C9/19 and ABAT polymorphisms on plasma concentration of valproic acid in Chinese epilepsy patients.	0
36787094	2023	CYP2C9 Polymorphisms and the Risk of Cardiovascular Events in Patients Treated with Clopidogrel: Combined Data from the POPular Genetics and POPular AGE Trials.	2
36855170	2023	Global distribution of functionally important CYP2C9 alleles and their inferred metabolic consequences.	10
36942299	2023	The role of CYP2C92, CYP2C93 and VKORC1-1639 variants on the susceptibility of upper gastrointestinal bleeding: A full case-control study.	3
36960518	2023	Prevalence of CYP2C9 and CYP2C19 variants and the impact on clopidogrel efficacy in patients having CYPC19*2 variant.	0
37008923	2023	Identification and in vitro functional assessment of 10 CYP2C9 variants found in Chinese Han subjects.	1
37222158	2023	The frequency of major ABCG2, SLCO1B1 and CYP2C9 variants in Asian, Native Hawaiian and Pacific Islander women subgroups: implications for personalized statins dosing.	0

Citation

Dessen P

CYP2C9 (cytochrome P450 family 2 subfamily C member 9)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/40245/cyp2c9-(cytochrome-p450-family-2-subfamily-c-member-9)