CYP3A4 (cytochrome P450 family 3 subfamily A member 4)

2003-02-01 Affiliation

Identity

HGNC

CYP3A4

LOCATION

7q22.1

LOCUSID

1576

ALIAS

CP33,CP34,CYP3A,CYP3A3,CYPIIIA3,CYPIIIA4,HLP,NF-25,P450C3,P450PCN1,VDDR3

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 1576
MIM: 124010
HGNC: 2637
Ensembl: ENSG00000160868

Variants:

dbSNP: 1576
ClinVar: 1576
TCGA: ENSG00000160868
COSMIC: CYP3A4

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000160868	ENST00000336411	A0A499FJM4
ENSG00000160868	ENST00000354593	E7EVM8
ENSG00000160868	ENST00000415003	C9JBD2
ENSG00000160868	ENST00000651514	P08684
ENSG00000160868	ENST00000651514	Q6GRK0
ENSG00000160868	ENST00000651783	A0A494C192
ENSG00000160868	ENST00000652018	A0A494C0W7

Expression (GTEx)

100

150

200

250

300

350

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Steroid hormone biosynthesis	KEGG	ko00140
Linoleic acid metabolism	KEGG	ko00591
Retinol metabolism	KEGG	ko00830
Metabolism of xenobiotics by cytochrome P450	KEGG	ko00980
Drug metabolism - cytochrome P450	KEGG	ko00982
Drug metabolism - other enzymes	KEGG	ko00983
Steroid hormone biosynthesis	KEGG	hsa00140
Linoleic acid metabolism	KEGG	hsa00591
Retinol metabolism	KEGG	hsa00830
Metabolism of xenobiotics by cytochrome P450	KEGG	hsa00980
Drug metabolism - cytochrome P450	KEGG	hsa00982
Drug metabolism - other enzymes	KEGG	hsa00983
Metabolic pathways	KEGG	hsa01100
Bile secretion	KEGG	ko04976
Bile secretion	KEGG	hsa04976
Chemical carcinogenesis	KEGG	hsa05204
Chemical carcinogenesis	KEGG	ko05204
Metabolism	REACTOME	R-HSA-1430728
Biological oxidations	REACTOME	R-HSA-211859
Phase 1 - Functionalization of compounds	REACTOME	R-HSA-211945
Cytochrome P450 - arranged by substrate type	REACTOME	R-HSA-211897
Xenobiotics	REACTOME	R-HSA-211981
Aflatoxin activation and detoxification	REACTOME	R-HSA-5423646

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA10026	aripiprazole	Chemical	VariantAnnotation	not associated	PK		25868121
PA10075	esomeprazole	Chemical	LabelAnnotation	associated
PA10084	fosamprenavir	Chemical	LabelAnnotation	associated
PA10202	telithromycin	Chemical	LabelAnnotation	associated
PA10232	vindesine	Chemical	VipGene	associated			9187528
PA10233	voriconazole	Chemical	ClinicalAnnotation, LabelAnnotation, VariantAnnotation	ambiguous	PK	PD	25515945, 28786228, 30306637
PA10251	atazanavir	Chemical	ClinicalAnnotation	associated	PK		22394315
PA10804	imatinib	Chemical	ClinicalAnnotation	associated	PK
PA128406956	fluorouracil	Chemical	VariantAnnotation	not associated		PD
PA130232992	bevacizumab	Chemical	VariantAnnotation	not associated		PD	27995989
PA131285527	oxaliplatin	Chemical	VariantAnnotation	not associated		PD	27995989
PA131301952	gefitinib	Chemical	VariantAnnotation	not associated	PK	PD	25554506, 26898617
PA133888799	Organ Transplantation	Disease	ClinicalAnnotation	associated	PK	PD	12966368, 17495880, 21635144, 21770725, 21902502, 22388796, 23459029, 23588314, 23778326, 24189425, 24444408, 24522145, 24658827, 26227094, 26228923, 26615671, 27225724, 27653228, 29043387, 29135906
PA133950441	hmg coa reductase inhibitors	Chemical	Literature, MultilinkAnnotation, Pathway	associated			23436703
PA134687924	erlotinib	Chemical	VariantAnnotation	associated		PD
PA134687937	mianserin	Chemical	VipGene	associated			9187528
PA134850491	Transplantation	Disease	ClinicalAnnotation, VariantAnnotation	ambiguous	PK	PD	21902502, 21903774, 23588314, 23778326, 23837477, 24052064, 24444408, 25141896, 25271728, 25287072, 25322286, 25588704, 27314545, 27653228, 28050888, 28342282, 28704257, 29043387, 29160300, 29256966
PA151958574	posaconazole	Chemical	LabelAnnotation	associated
PA153619853	dronedarone	Chemical	LabelAnnotation	associated
PA154410481	prasugrel	Chemical	Literature, MultilinkAnnotation	associated			21828263
PA161925594	tropisetron	Chemical	VipGene	associated			9187528
PA162372840	sunitinib	Chemical	LabelAnnotation, MultilinkAnnotation, VariantAnnotation	associated	PK		17825686, 24566734
PA163522472	darunavir	Chemical	LabelAnnotation	associated
PA163522473	tipranavir	Chemical	LabelAnnotation	associated
PA164722621	MIR27A	Gene	MultilinkAnnotation	associated			26229046
PA164744924	trimethadione	Chemical	VipGene	associated			9187528
PA164746007	ranolazine	Chemical	VipGene	associated			9187528
PA164746311	everolimus	Chemical	ClinicalAnnotation, VariantAnnotation	ambiguous	PK		24628014
PA164746757	tolterodine	Chemical	LabelAnnotation	associated
PA164748728	mycophenolic acid	Chemical	Pathway	associated			24220207
PA164748765	dorzolamide	Chemical	VipGene	associated			9187528
PA164776964	desloratadine	Chemical	VipGene	associated			9187528
PA164781320	flunitrazepam	Chemical	Pathway	associated
PA164784002	sertindole	Chemical	VipGene	associated			9187528
PA164924493	axitinib	Chemical	VariantAnnotation	not associated	PK		22170007
PA165108401	Acute coronary syndrome	Disease	ClinicalAnnotation	associated	PK		25935875
PA165111696	artemisinin	Chemical	Pathway	associated
PA165111698	artemether	Chemical	Pathway	associated
PA165111722	lumefantrine	Chemical	ClinicalAnnotation	associated	PK	PD
PA165260403	arteether	Chemical	Pathway	associated
PA165291492	pazopanib	Chemical	MultilinkAnnotation	associated			22341567
PA165374673	ticagrelor	Chemical	ClinicalAnnotation	associated	PK		25935875
PA165817016	Kidney Transplantation	Disease	ClinicalAnnotation, VariantAnnotation	ambiguous	PK	PD	12966368, 15707415, 21635144, 23459029, 23557867, 23974086, 24444408, 24691060, 25240575, 25287072, 25588704, 26227094, 26228923, 26615671, 27225724, 28050888, 28704257, 28945481, 29043387, 29135906, 29318894, 29454235, 29469606, 29546446
PA165819201	CYP3A4*1	Haplotype	VipGene	associated			3267210
PA165819202	CYP3A4*1A	Haplotype	VipGene	associated			3267210
PA165819203	CYP3A4*1B	Haplotype	VipGene	associated			10548319, 10660343, 10668853, 11181494, 11959896, 12107441, 12142725, 12439220, 12692107, 14515059, 14673875, 16765145, 17367411, 17434921, 9719084, 10511065
PA165819204	CYP3A4*1C	Haplotype	VipGene	associated			11279519
PA165819205	CYP3A4*1D	Haplotype	VipGene	associated			11279519
PA165819206	CYP3A4*1E	Haplotype	VipGene	associated			11890939
PA165819207	CYP3A4*1F	Haplotype	VipGene	associated			11890939
PA165819208	CYP3A4*1G	Haplotype	VipGene	associated			14695543, 11714865
PA165819209	CYP3A4*1H	Haplotype	VipGene	associated			14695543, 11714865
PA165819210	CYP3A4*1J	Haplotype	VipGene	associated			14695543
PA165819211	CYP3A4*1K	Haplotype	VipGene	associated			14695543
PA165819212	CYP3A4*1L	Haplotype	VipGene	associated			14695543
PA165819213	CYP3A4*1M	Haplotype	VipGene	associated			14695543
PA165819214	CYP3A4*1N	Haplotype	VipGene	associated			14695543, 11714865
PA165819215	CYP3A4*1P	Haplotype	VipGene	associated			14695543
PA165819216	CYP3A4*1Q	Haplotype	VipGene	associated			14695543
PA165819217	CYP3A4*1R	Haplotype	VipGene	associated			14695543
PA165819218	CYP3A4*1S	Haplotype	VipGene	associated			14695543, 11714865
PA165819219	CYP3A4*1T	Haplotype	VipGene	associated			14695543
PA165819220	CYP3A4*2	Haplotype	VipGene	associated			14580164, 10668853
PA165819221	CYP3A4*3	Haplotype	VipGene	associated			11375299, 10668853
PA165819222	CYP3A4*4	Haplotype	VipGene	associated			11181494
PA165819223	CYP3A4*5	Haplotype	VipGene	associated			11181494
PA165819224	CYP3A4*6	Haplotype	VipGene	associated			11181494
PA165819225	CYP3A4*7	Haplotype	VipGene	associated			11470997
PA165819226	CYP3A4*8	Haplotype	VipGene	associated			11470997
PA165819227	CYP3A4*9	Haplotype	VipGene	associated			11470997
PA165819228	CYP3A4*10	Haplotype	VipGene	associated			11875366, 11470997
PA165819229	CYP3A4*11	Haplotype	VipGene	associated			11470997
PA165819230	CYP3A4*12	Haplotype	VipGene	associated			11470997
PA165819231	CYP3A4*13	Haplotype	VipGene	associated			11470997
PA165819232	CYP3A4*14	Haplotype	VipGene	associated			11875366
PA165819234	CYP3A4*15A	Haplotype	VipGene	associated			11875366, 11714865
PA165819235	CYP3A4*15B	Haplotype	VipGene	associated			11890939
PA165819237	CYP3A4*16A	Haplotype	VipGene	associated			11875366
PA165819238	CYP3A4*16B	Haplotype	VipGene	associated			14695543, 16890579, 11714865
PA165819239	CYP3A4*17	Haplotype	VipGene	associated			15634941, 11714865
PA165819241	CYP3A4*18A	Haplotype	VipGene	associated			15634941, 11714865
PA165819242	CYP3A4*18B	Haplotype	VipGene	associated			14695543, 11714865
PA165819243	CYP3A4*19	Haplotype	VipGene	associated			15634941, 11714865
PA165819244	CYP3A4*20	Haplotype	VipGene	associated			16580902
PA165860521	ambrisentan	Chemical	MultilinkAnnotation	not associated			25286744
PA165946873	vemurafenib	Chemical	MultilinkAnnotation	associated			23116250
PA165948902	boceprevir	Chemical	LabelAnnotation	associated
PA165958354	telaprevir	Chemical	LabelAnnotation	associated
PA165958365	vilazodone	Chemical	MultilinkAnnotation	associated			21951984
PA165958376	fesoterodine	Chemical	ClinicalAnnotation	associated	PK
PA165958401	cabazitaxel	Chemical	LabelAnnotation	associated
PA166048680	CYP3A4*22	Haplotype	GuidelineAnnotation	associated
PA166114454	transplant rejection	Disease	ClinicalAnnotation, VariantAnnotation	ambiguous	PK	PD	27653228, 29043387
PA166114455	acute cellular rejection	Disease	VariantAnnotation	ambiguous		PD	24189425
PA166114457	lung transplantation	Disease	VariantAnnotation	not associated	PK		24628014
PA166114961	dolutegravir	Chemical	LabelAnnotation	associated
PA166115462	dry mouth	Disease	VariantAnnotation	associated		PD	23559402
PA166122590	simeprevir	Chemical	LabelAnnotation	associated
PA166123204	bioavailability	Disease	VariantAnnotation	associated	PK		24598718
PA166123386	ruxolitinib	Chemical	LabelAnnotation	associated
PA166123415	ivabradine	Chemical	LabelAnnotation	associated
PA166124372	treatment modification	Disease	VariantAnnotation	associated		PD	25398452
PA166124478	endoxifen	Chemical	VariantAnnotation	not associated	PK		29436156
PA166127651	n-desmethyltamoxifen	Chemical	VariantAnnotation	not associated	PK		29436156
PA166127652	4-hydroxytamoxifen	Chemical	VariantAnnotation	not associated	PK		29436156
PA166128219	CYP3A5*3	Haplotype	GuidelineAnnotation	associated
PA166151827	adverse events	Disease	VariantAnnotation	not associated		PD	21223952
PA166153431	flibanserin	Chemical	LabelAnnotation	associated
PA166157345	rs2242480	Variant	VipGene	associated			14695543, 15634941, 16890579, 11714865
PA166157367	rs2740574	Variant	VipGene	associated			10548319, 10660343, 10668853, 11181494, 11890939, 11959896, 12107441, 12142725, 12439220, 12692107, 14515059, 14673875, 16765145, 17367411, 17434921, 9719084, 10511065
PA166157392	rs4646438	Variant	VipGene	associated			11181494
PA166157402	rs4986907	Variant	VipGene	associated			11875366, 11890939, 11714865
PA166157403	rs4986908	Variant	VipGene	associated			11875366, 11470997
PA166157404	rs4986909	Variant	VipGene	associated			11470997
PA166157405	rs4986910	Variant	VipGene	associated			11375299, 10668853
PA166157406	rs4986913	Variant	VipGene	associated			15634941, 11714865
PA166157408	rs4987161	Variant	VipGene	associated			15634941, 11714865
PA166157460	rs12721627	Variant	VipGene	associated			11875366, 14695543, 16890579, 11714865
PA166157461	rs12721629	Variant	VipGene	associated			11470997
PA166157462	rs12721634	Variant	VipGene	associated			11875366
PA166157481	rs28371759	Variant	VipGene	associated			14695543, 15634941, 11714865
PA166157491	rs55785340	Variant	VipGene	associated			14580164, 10668853
PA166157493	rs55901263	Variant	VipGene	associated			11181494
PA166157494	rs55951658	Variant	VipGene	associated			11181494
PA166157496	rs56324128	Variant	VipGene	associated			11470997
PA166157502	rs67666821	Variant	VipGene	associated			16580902
PA166157503	rs67784355	Variant	VipGene	associated			11470997
PA166157506	rs72552798	Variant	VipGene	associated			11470997
PA166157507	rs72552799	Variant	VipGene	associated			11470997
PA166158243	CYP3A4 -444T>G	Variant	VipGene	associated			11279519
PA166158244	CYP3A4 -369T>A	Variant	VipGene	associated			11890939
PA166158333	CYP3A4 -630A>G	Variant	VipGene	associated			14695543
PA166158334	CYP3A4 14200T>G	Variant	VipGene	associated			14695543, 11714865
PA166158335	CYP3A4 15727G>A	Variant	VipGene	associated			14695543
PA166158336	CYP3A4 16775A>G	Variant	VipGene	associated			14695543
PA166158426	CYP3A4 -655A>G	Variant	VipGene	associated			14695543
PA166158520	CYP3A4 -62C>A	Variant	VipGene	associated			11279519
PA166158521	CYP3A4 -747C>G	Variant	VipGene	associated			11890939
PA166158522	CYP3A4 26206C>A	Variant	VipGene	associated			14695543
PA166158613	CYP3A4 -156C>A	Variant	VipGene	associated			14695543
PA166158614	CYP3A4 15809T>C	Variant	VipGene	associated			14695543
PA166158705	CYP3A4 6077A>G	Variant	VipGene	associated			14695543
PA166158706	CYP3A4 17815_17816delAT	Variant	VipGene	associated			14695543, 11714865
PA166158707	CYP3A4 26013T>C	Variant	VipGene	associated			14695543
PA166158708	CYP3A4 -845-844insATGGAGTGA	Variant	VipGene	associated			11890939
PA166163418	rucaparib	Chemical	LabelAnnotation	associated
PA166165251	4-beta-hydroxycholesterol	Chemical	VariantAnnotation	not associated
PA166169562	laparoscopic sleeve gastrectomy	Disease	VariantAnnotation	not associated	PK		28342282
PA166178554	(S)-methadone	Chemical	VariantAnnotation	associated	PK		17178267
PA378	NR1I2	Gene	Pathway	associated			21151855, 21738081, 22722338
PA391	NR1I3	Gene	Pathway	associated			21738081
PA443309	Alcoholism	Disease	ClinicalAnnotation	associated		PD	32112986
PA443314	Alopecia	Disease	ClinicalAnnotation	associated		PD
PA443560	Breast Neoplasms	Disease	ClinicalAnnotation, VariantAnnotation	ambiguous	PK	PD	17434921, 19376514, 24744093, 25398452, 27549341, 29436156
PA443622	Carcinoma, Non-Small-Cell Lung	Disease	ClinicalAnnotation, VariantAnnotation	ambiguous	PK	PD	16890579, 25554506, 26898617
PA443731	Chronic Disease	Disease	ClinicalAnnotation	associated		PD	21946898, 28482130
PA443796	Coronary Artery Disease	Disease	ClinicalAnnotation	associated		PD	16645157, 17697139, 18004210, 19576320, 24140730, 24262617, 28135763
PA443886	Diabetes Mellitus	Disease	VariantAnnotation	not associated		PD	29546446
PA443928	Dizziness	Disease	VariantAnnotation	not associated		PD	23313934
PA443937	Drug Toxicity	Disease	VariantAnnotation	not associated		PD	23974086, 25554506, 27995989
PA444065	Epilepsy	Disease	ClinicalAnnotation	associated	PK		23252947, 25495409, 26421491
PA444109	Exanthema	Disease	VariantAnnotation	associated		PD
PA444370	Heart Failure	Disease	ClinicalAnnotation, VariantAnnotation	associated	PK		28440343
PA444460	Heroin Dependence	Disease	ClinicalAnnotation	associated		PD	21902501
PA444516	Hypercholesterolemia	Disease	ClinicalAnnotation, VariantAnnotation	ambiguous	PK	PD	23252946, 24598718, 25051018, 26164721, 28482130
PA444528	Hyperlipidemias	Disease	ClinicalAnnotation, VariantAnnotation	ambiguous		PD	15650881, 18528690
PA444552	Hypertension	Disease	ClinicalAnnotation	associated		PD
PA444859	Malaria	Disease	ClinicalAnnotation	associated	PK	PD
PA445009	Mycoses	Disease	ClinicalAnnotation	associated	PK		25515945
PA445043	Opioid-Related Disorders	Disease	ClinicalAnnotation, VariantAnnotation	associated	PK	PD	17178267, 31676110
PA445048	Nausea	Disease	VariantAnnotation	not associated		PD	21128989, 23313934
PA445062	Neoplasms	Disease	ClinicalAnnotation, VariantAnnotation	ambiguous	PK	PD	16890579, 18509327, 21404110, 23327575, 24704000, 25495407, 26114223, 27574448
PA445089	Nephrotic Syndrome	Disease	VariantAnnotation	not associated		PD
PA445204	Ovarian Neoplasms	Disease	ClinicalAnnotation, VariantAnnotation	associated		PD	25398452
PA445208	Pain	Disease	ClinicalAnnotation, VariantAnnotation	associated	PK	PD	26407542, 29926893, 31773688
PA445210	Pain, Postoperative	Disease	ClinicalAnnotation, VariantAnnotation	ambiguous	PK	PD	19784640, 21128989, 21223952, 21513075, 21535061, 23313934, 23557865, 25794200, 29601950
PA445301	Peripheral Nervous System Diseases	Disease	VariantAnnotation	associated		PD	25398452
PA445425	Prostatic Neoplasms	Disease	VipGene	associated			12107441, 9719084, 10548319
PA445522	Respiratory Insufficiency	Disease	ClinicalAnnotation	associated		PD	31773688
PA445742	Stomach Neoplasms	Disease	VariantAnnotation	not associated		PD	27995989
PA445828	Testicular Neoplasms	Disease	ClinicalAnnotation	associated		PD
PA446051	Vomiting	Disease	VariantAnnotation	not associated		PD	21128989, 23313934
PA446108	Colorectal Neoplasms	Disease	VariantAnnotation	not associated		PD
PA446155	Precursor Cell Lymphoblastic Leukemia-Lymphoma	Disease	MultilinkAnnotation	associated			25266680
PA446199	Overdose	Disease	VariantAnnotation	not associated		PD	30306637
PA446411	Endometrial Neoplasms	Disease	VipGene	associated			17434921
PA446661	Carcinoma, Small Cell	Disease	VipGene	associated			14515059
PA446852	Hot Flashes	Disease	VariantAnnotation	associated		PD	24744093
PA446863	Hepatitis C, Chronic	Disease	VipGene	associated			12087352
PA446876	Substance-Related Disorders	Disease	ClinicalAnnotation	associated	PK		26129906
PA447196	Anxiety Disorders	Disease	ClinicalAnnotation	associated		PD	32112986
PA447199	Bipolar Disorder	Disease	ClinicalAnnotation	associated	PK		26129906
PA447215	Psychotic Disorders	Disease	VariantAnnotation	not associated	PK		23609392, 25868121
PA447230	HIV Infections	Disease	ClinicalAnnotation	associated	PK		15622315, 16267764, 24950369, 27142945
PA447247	liver transplantation	Disease	ClinicalAnnotation, VariantAnnotation	ambiguous	PK	PD	24189425, 27653228, 29318894, 29454235
PA447278	Depression	Disease	ClinicalAnnotation	associated	PK		26129906
PA447322	therapy-related acute myeloid leukemia (t-ML)	Disease	VipGene	associated			12439220
PA448015	acetaminophen	Chemical	Literature, MultilinkAnnotation, Pathway, VipGene	ambiguous			11866476, 19219744, 26049587, 9187528
PA448333	alprazolam	Chemical	ClinicalAnnotation, Pathway	associated	PK	PD	32112986
PA448383	amiodarone	Chemical	VipGene	associated			9187528
PA448385	amitriptyline	Chemical	VipGene	associated			9187528
PA448388	amlodipine	Chemical	ClinicalAnnotation	associated		PD
PA448498	astemizole	Chemical	VipGene	associated			9187528
PA448500	atorvastatin	Chemical	ClinicalAnnotation, Pathway, VariantAnnotation	associated		PD	18528690, 19802823
PA448586	benzphetamine	Chemical	VipGene	associated			9187528
PA448645	bleomycin	Chemical	ClinicalAnnotation	associated		PD
PA448681	budesonide	Chemical	VipGene	associated			9187528
PA448685	buprenorphine	Chemical	ClinicalAnnotation, VariantAnnotation	associated		PD	26407542, 31676110
PA448771	capecitabine	Chemical	VariantAnnotation	not associated		PD	27995989
PA448785	carbamazepine	Chemical	ClinicalAnnotation, MultilinkAnnotation, Pathway, VipGene	associated	PK		21738081, 23252947, 25495409, 26421491, 26574235, 9187528
PA448871	celecoxib	Chemical	Pathway	associated			22336956
PA448971	chlorzoxazone	Chemical	VipGene	associated			9187528
PA449011	cisapride	Chemical	VipGene	associated			9187528
PA449014	cisplatin	Chemical	ClinicalAnnotation, VariantAnnotation	ambiguous		PD	27995989
PA449015	citalopram	Chemical	Pathway	associated			21546862
PA449028	clarithromycin	Chemical	MultilinkAnnotation, VipGene	associated			9187528, 9951426
PA449048	clomipramine	Chemical	Pathway, VipGene	associated			9187528
PA449050	clonazepam	Chemical	VipGene	associated			9187528
PA449053	clopidogrel	Chemical	ClinicalAnnotation, Literature, MultilinkAnnotation, Pathway, VariantAnnotation	ambiguous		PD	16645157, 17697139, 18004210, 19576320, 20938371, 21828263, 24140730, 24262617, 28135763
PA449061	clozapine	Chemical	MultilinkAnnotation	associated			23297297
PA449072	cocaine	Chemical	VipGene	associated			9187528
PA449088	codeine	Chemical	VipGene	associated			9187528
PA449165	cyclophosphamide	Chemical	ClinicalAnnotation	associated		PD	19376514
PA449167	cyclosporine	Chemical	ClinicalAnnotation, Pathway, VariantAnnotation	ambiguous	PK	PD	21902502, 22388796, 23557867, 23922006, 24522145, 24658827, 24691060, 25240575, 25976223, 27653228, 29043387, 29135906
PA449211	dapsone	Chemical	VipGene	associated			9187528
PA449233	desipramine	Chemical	Pathway	associated
PA449273	dextromethorphan	Chemical	VipGene	associated			9187528
PA449283	diazepam	Chemical	Pathway, VipGene	associated			9187528
PA449334	diltiazem	Chemical	VipGene	associated			9187528
PA449383	docetaxel	Chemical	ClinicalAnnotation, Pathway, VariantAnnotation, VipGene	ambiguous	PK	PD	18509327, 21151855, 24704000, 25495407, 27574448, 27995989, 9187528
PA449390	dolasetron	Chemical	VipGene	associated			9187528
PA449409	doxepin	Chemical	Pathway	associated
PA449412	doxorubicin	Chemical	VipGene	associated			9187528
PA449441	efavirenz	Chemical	ClinicalAnnotation	associated	PK		15622315, 16267764
PA449456	enalapril	Chemical	VipGene	associated			9187528
PA449476	epirubicin	Chemical	VariantAnnotation	not associated		PD	27995989
PA449493	erythromycin	Chemical	ClinicalAnnotation, VipGene	associated	PK		23327575, 9187528
PA449533	ethosuximide	Chemical	VipGene	associated			9187528
PA449552	etoposide	Chemical	ClinicalAnnotation	associated		PD
PA449563	exemestane	Chemical	ClinicalAnnotation, VariantAnnotation	ambiguous	PK		27549341
PA449590	felbamate	Chemical	VipGene	associated			9187528
PA449591	felodipine	Chemical	VipGene	associated			9187528
PA449599	fentanyl	Chemical	ClinicalAnnotation, VariantAnnotation, VipGene	ambiguous	PK	PD	19784640, 21128989, 21223952, 21513075, 21535061, 23313934, 23557865, 25794200, 26088794, 29601950, 30281924, 9187528
PA449673	fluoxetine	Chemical	Pathway	associated
PA449685	flutamide	Chemical	VipGene	associated			9187528
PA449688	fluvastatin	Chemical	ClinicalAnnotation, Pathway	associated		PD	16103896
PA449809	granisetron	Chemical	VipGene	associated			9187528
PA449841	haloperidol	Chemical	VariantAnnotation	not associated	PK		25868121
PA449905	hydrocortisone	Chemical	VipGene	associated			9187528
PA449957	ibuprofen	Chemical	Pathway	associated			25502615
PA449969	imipramine	Chemical	Pathway, VipGene	associated			9187528
PA449977	indinavir	Chemical	ClinicalAnnotation, LabelAnnotation, VipGene	associated	PK		9187528
PA450085	irinotecan	Chemical	VariantAnnotation	not associated		PD
PA450132	itraconazole	Chemical	VipGene	associated			9187528
PA450146	ketoconazole	Chemical	VipGene	associated			9187528
PA450226	lidocaine	Chemical	VipGene	associated			9187528
PA450264	lopinavir	Chemical	ClinicalAnnotation	associated	PK		24950369, 27142945
PA450268	losartan	Chemical	LabelAnnotation, Pathway, VipGene	associated			9187528
PA450272	lovastatin	Chemical	Pathway	associated
PA450373	mephenytoin	Chemical	VipGene	associated			9187528
PA450401	methadone	Chemical	ClinicalAnnotation, VipGene	associated		PD	21902501, 9187528
PA450434	methoxyflurane	Chemical	VipGene	associated			9187528
PA450494	miconazole	Chemical	VipGene	associated			9187528
PA450496	midazolam	Chemical	ClinicalAnnotation, Pathway, VariantAnnotation, VipGene	associated	PK		19255940, 23327575, 25287072, 26114223, 9187528
PA450500	mifepristone	Chemical	VipGene	associated			9187528
PA450600	nateglinide	Chemical	Pathway	associated
PA450606	nelfinavir	Chemical	LabelAnnotation	associated
PA450616	nevirapine	Chemical	Pathway	associated
PA450620	nicardipine	Chemical	VipGene	associated			9187528
PA450631	nifedipine	Chemical	ClinicalAnnotation, VariantAnnotation, VipGene	ambiguous	PK		15634941, 9187528
PA450688	olanzapine	Chemical	VariantAnnotation	associated		PD	23559402
PA450704	omeprazole	Chemical	LabelAnnotation, VipGene	associated			9187528
PA450705	ondansetron	Chemical	VipGene	associated			9187528
PA450731	oxazepam	Chemical	Pathway	associated
PA450761	paclitaxel	Chemical	ClinicalAnnotation, Pathway, VariantAnnotation, VipGene	associated	PK	PD	16890579, 21151855, 25398452, 9187528
PA450801	paroxetine	Chemical	Pathway	associated
PA450921	phenprocoumon	Chemical	VariantAnnotation	ambiguous		PD	23510058, 24224579, 25461249, 30207196
PA450965	pimozide	Chemical	MultilinkAnnotation, VariantAnnotation	ambiguous	PK		25868121, 9580580, 9951426
PA451096	prednisolone	Chemical	VipGene	associated			9187528
PA451124	proguanil	Chemical	VipGene	associated			9187528
PA451131	propafenone	Chemical	VipGene	associated			9187528
PA451201	quetiapine	Chemical	ClinicalAnnotation	associated	PK
PA451209	quinidine	Chemical	MultilinkAnnotation, VipGene	associated			11353757, 9187528
PA451213	quinine	Chemical	VipGene	associated			9187528
PA451234	repaglinide	Chemical	Pathway	associated
PA451250	rifampin	Chemical	Literature, MultilinkAnnotation	associated			24839948
PA451257	risperidone	Chemical	ClinicalAnnotation, VariantAnnotation	ambiguous	PK		23609392, 25868121, 26129906
PA451260	ritonavir	Chemical	LabelAnnotation, VipGene	associated			9187528
PA451271	ropivacaine	Chemical	VipGene	associated			9187528
PA451305	saquinavir	Chemical	VipGene	associated			9187528
PA451316	selegiline	Chemical	VipGene	associated			9187528
PA451333	sertraline	Chemical	VipGene	associated			9187528
PA451341	sevoflurane	Chemical	VipGene	associated			9187528
PA451346	sildenafil	Chemical	ClinicalAnnotation, VariantAnnotation	associated	PK		28440343
PA451363	simvastatin	Chemical	ClinicalAnnotation, Literature, MultilinkAnnotation, Pathway, VariantAnnotation	ambiguous	PK	PD	15650881, 18528690, 19802823, 21946898, 23252946, 24598718, 25051018, 26164721, 28482130
PA451365	sirolimus	Chemical	ClinicalAnnotation, LabelAnnotation, VariantAnnotation	ambiguous	PK	PD	15707415, 23974086
PA451527	sufentanil	Chemical	ClinicalAnnotation, VariantAnnotation	associated	PK	PD	29926893, 31773688
PA451539	sulfadiazine	Chemical	VipGene	associated			9187528
PA451544	sulfamethoxazole	Chemical	VipGene	associated			9187528
PA451550	sulfinpyrazone	Chemical	VipGene	associated			9187528
PA451578	tacrolimus	Chemical	ClinicalAnnotation, GuidelineAnnotation, MultilinkAnnotation, Pathway, VariantAnnotation	ambiguous	PK	PD	12966368, 17495880, 21635144, 21770725, 21902502, 21903774, 23459029, 23557867, 23588314, 23778326, 23837477, 23922006, 24052064, 24189425, 24444408, 25141896, 25271728, 25287072, 25322286, 25588704, 26039043, 26227094, 26228923, 26615671, 27225724, 27314545, 27653228, 28050888, 28342282, 28704257, 28945481, 29043387, 29160300, 29256966, 29318894, 29454235, 29469606, 29546446
PA451581	tamoxifen	Chemical	ClinicalAnnotation, Pathway, VariantAnnotation	ambiguous	PK	PD	17434921, 23962908, 24744093, 29436156
PA451583	tamsulosin	Chemical	LabelAnnotation, VipGene	associated			9187528
PA451608	temazepam	Chemical	Pathway	associated
PA451619	terfenadine	Chemical	VipGene	associated			9187528
PA451627	testosterone	Chemical	VipGene	associated			9187528
PA451647	theophylline	Chemical	Pathway, VipGene	associated			9187528
PA451731	toremifene	Chemical	VipGene	associated			9187528
PA451735	tramadol	Chemical	Pathway	associated			24849324
PA451743	trastuzumab	Chemical	VariantAnnotation	not associated		PD	27995989
PA451753	triazolam	Chemical	Pathway	associated
PA451788	trimethoprim	Chemical	VipGene	associated			9187528
PA451868	verapamil	Chemical	VipGene	associated			9187528
PA451877	vinblastine	Chemical	VipGene	associated			9187528
PA451879	vincristine	Chemical	Pathway, VariantAnnotation, VipGene	ambiguous	PK		21404110, 9187528
PA451906	warfarin	Chemical	MultilinkAnnotation	associated			11353757
PA451954	zidovudine	Chemical	Pathway, VipGene	associated			22960662, 9187528
PA451976	zolpidem	Chemical	VipGene	associated			9187528
PA451978	zonisamide	Chemical	LabelAnnotation, VipGene	associated			9187528
PA452233	antipsychotics	Chemical	VariantAnnotation	not associated	PK		25868121
PA452632	acenocoumarol	Chemical	VariantAnnotation	not associated		PD	23510058
PA7000	sorafenib	Chemical	Pathway	associated			28362716

References

Pubmed ID	Year	Title	Citations
16954191	2006	Structural basis for ligand promiscuity in cytochrome P450 3A4.	203
15256616	2004	Crystal structures of human cytochrome P450 3A4 bound to metyrapone and progesterone.	195
15622315	2004	Pharmacogenetics of efavirenz and central nervous system side effects: an Adult AIDS Clinical Trials Group study.	175
15258162	2004	The structure of human microsomal cytochrome P450 3A4 determined by X-ray crystallography to 2.05-A resolution.	169
17900275	2007	Common polymorphisms of CYP2C19 and CYP2C9 affect the pharmacokinetic and pharmacodynamic response to clopidogrel but not prasugrel.	133
19833260	2009	The SLCO1B1*5 genetic variant is associated with statin-induced side effects.	116
20386561	2011	Intronic polymorphism in CYP3A4 affects hepatic expression and response to statin drugs.	115
20386561	2011	Intronic polymorphism in CYP3A4 affects hepatic expression and response to statin drugs.	115
16538176	2006	Genetic susceptibility to carbamazepine-induced cutaneous adverse drug reactions.	112
12966368	2003	Genetic polymorphisms of the CYP3A4, CYP3A5, and MDR-1 genes and pharmacokinetics of the calcineurin inhibitors cyclosporine and tacrolimus.	98

Citation

Dessen P

CYP3A4 (cytochrome P450 family 3 subfamily A member 4)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40250/cyp3a4-(cytochrome-p450-family-3-subfamily-a-member-4)