DAPK3 (death associated protein kinase 3)

2003-11-01  

Identity

HGNC
LOCATION
19p13.3
LOCUSID
ALIAS
DLK,ZIP,ZIPK
FUSION GENES

Other Information

Locus ID:

NCBI: 1613
MIM: 603289
HGNC: 2676
Ensembl: ENSG00000167657

Variants:

dbSNP: 1613
ClinVar: 1613
TCGA: ENSG00000167657
COSMIC: DAPK3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000167657ENST00000301264O43293
ENSG00000167657ENST00000545797O43293
ENSG00000167657ENST00000593844M0QYW5
ENSG00000167657ENST00000594894M0QYY8
ENSG00000167657ENST00000596311M0R0D0
ENSG00000167657ENST00000601824M0R0D0

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Autophagy - animalKEGGko04140
Bladder cancerKEGGko05219
Autophagy - animalKEGGhsa04140
Pathways in cancerKEGGhsa05200
Bladder cancerKEGGhsa05219
Programmed Cell DeathREACTOMER-HSA-5357801
ApoptosisREACTOMER-HSA-109581
Caspase activation via extrinsic apoptotic signalling pathwayREACTOMER-HSA-5357769
Ligand-independent caspase activation via DCCREACTOMER-HSA-418889

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
129173392003ZIP kinase triggers apoptosis from nuclear PML oncogenic domains.25
214870362011Cancer-associated loss-of-function mutations implicate DAPK3 as a tumor-suppressing kinase.24
152922222004Identification and characterization of zipper-interacting protein kinase as the unique vascular smooth muscle myosin phosphatase-associated kinase.16
191170592009Downregulation of ZIP kinase is associated with tumor invasion, metastasis and poor prognosis in gastric cancer.11
280114582017Insulin and Glucose Alter Death-Associated Protein Kinase 3 (DAPK3) DNA Methylation in Human Skeletal Muscle.10
261173362015Oncogenic miR-17/20a Forms a Positive Feed-forward Loop with the p53 Kinase DAPK3 to Promote Tumorigenesis.9
280754592017Death-associated protein kinase 3 controls the tumor progression of A549 cells through ERK MAPK/c-Myc signaling.9
180843232008ZIP kinase plays a crucial role in androgen receptor-mediated transcription.8
287311732017Anacardic acid induces cell apoptosis of prostatic cancer through autophagy by ER stress/DAPK3/Akt signaling pathway.8
214546792011Zipper-interacting protein kinase (ZIPK) modulates canonical Wnt/beta-catenin signaling through interaction with Nemo-like kinase and T-cell factor 4 (NLK/TCF4).7

Citation

Dessen P

DAPK3 (death associated protein kinase 3)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/40264/dapk3-(death-associated-protein-kinase-3)