DCDC2 (doublecortin domain containing 2)

2003-06-01  

Identity

HGNC
DCDC2
LOCATION
6p22.3
LOCUSID
51473
ALIAS
DCDC2A,DFNB66,NPHP19,NSC,RU2,RU2S
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 51473
MIM: 605755
HGNC: 18141
Ensembl: ENSG00000146038

Variants:

dbSNP: 51473
ClinVar: 51473
TCGA: ENSG00000146038
COSMIC: DCDC2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000146038ENST00000378450Q9UHG0
ENSG00000146038ENST00000378454Q9UHG0
ENSG00000146038ENST00000436313H0Y784

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
162782972005DCDC2 is associated with reading disability and modulates neuronal development in the brain.135
163854492006Strong genetic evidence of DCDC2 as a susceptibility gene for dyslexia.78
163854492006Strong genetic evidence of DCDC2 as a susceptibility gene for dyslexia.78
170336332006Further evidence that the KIAA0319 gene confers susceptibility to developmental dyslexia.66
214579492011DCDC2, KIAA0319 and CMIP are associated with reading-related traits.62
226830912012Three dyslexia susceptibility genes, DYX1C1, DCDC2, and KIAA0319, affect temporo-parietal white matter structure.60
216982302011Increased expression of the dyslexia candidate gene DCDC2 affects length and signaling of primary cilia in neurons.46
192385502009The role of gene DCDC2 in German dyslexics.41
192385502009The role of gene DCDC2 in German dyslexics.41
200685902010Dyslexia and DCDC2: normal variation in reading and spelling is associated with DCDC2 polymorphisms in an Australian population sample.41

Citation

Dessen P

DCDC2 (doublecortin domain containing 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/40269/dcdc2-(doublecortin-domain-containing-2)