DCN (decorin)

2003-02-01  

Identity

HGNC
DCN
LOCATION
12q21.33
LOCUSID
1634
ALIAS
CSCD,DSPG2,PG40,PGII,PGS2,SLRR1B
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 1634
MIM: 125255
HGNC: 2705
Ensembl: ENSG00000011465

Variants:

dbSNP: 1634
ClinVar: 1634
TCGA: ENSG00000011465
COSMIC: DCN

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000011465ENST00000052754P07585
ENSG00000011465ENST00000052754Q6FH10
ENSG00000011465ENST00000393155P07585
ENSG00000011465ENST00000393155Q6FH10
ENSG00000011465ENST00000420120P07585
ENSG00000011465ENST00000425043P07585
ENSG00000011465ENST00000425043A0A024RBG6
ENSG00000011465ENST00000441303P07585
ENSG00000011465ENST00000456569P07585
ENSG00000011465ENST00000546370F8VNW0
ENSG00000011465ENST00000546391F8VNV6
ENSG00000011465ENST00000546745F8VU58
ENSG00000011465ENST00000547568P07585
ENSG00000011465ENST00000547568A0A024RBG6
ENSG00000011465ENST00000547937F8VWU0
ENSG00000011465ENST00000548218H0YI87
ENSG00000011465ENST00000549513F8VX58
ENSG00000011465ENST00000550099F8VU58
ENSG00000011465ENST00000550563F8VXZ8
ENSG00000011465ENST00000550758H0YIH3
ENSG00000011465ENST00000551354F8VSI3
ENSG00000011465ENST00000552145F8VUF6
ENSG00000011465ENST00000552962P07585
ENSG00000011465ENST00000552962Q6FH10

Expression (GTEx)

0
100
200
300
400
500
600
700
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
TGF-beta signaling pathwayKEGGko04350
TGF-beta signaling pathwayKEGGhsa04350
Proteoglycans in cancerKEGGhsa05205
Proteoglycans in cancerKEGGko05205
DiseaseREACTOMER-HSA-1643685
Diseases of glycosylationREACTOMER-HSA-3781865
Diseases associated with glycosaminoglycan metabolismREACTOMER-HSA-3560782
Defective B4GALT7 causes EDS, progeroid typeREACTOMER-HSA-3560783
Defective B3GAT3 causes JDSSDHDREACTOMER-HSA-3560801
Defective CHSY1 causes TPBSREACTOMER-HSA-3595177
Defective CHST3 causes SEDCJDREACTOMER-HSA-3595172
Defective CHST14 causes EDS, musculocontractural typeREACTOMER-HSA-3595174
MetabolismREACTOMER-HSA-1430728
Metabolism of carbohydratesREACTOMER-HSA-71387
Glycosaminoglycan metabolismREACTOMER-HSA-1630316
Heparan sulfate/heparin (HS-GAG) metabolismREACTOMER-HSA-1638091
A tetrasaccharide linker sequence is required for GAG synthesisREACTOMER-HSA-1971475
Chondroitin sulfate/dermatan sulfate metabolismREACTOMER-HSA-1793185
Chondroitin sulfate biosynthesisREACTOMER-HSA-2022870
Dermatan sulfate biosynthesisREACTOMER-HSA-2022923
CS/DS degradationREACTOMER-HSA-2024101
Extracellular matrix organizationREACTOMER-HSA-1474244
ECM proteoglycansREACTOMER-HSA-3000178
Degradation of the extracellular matrixREACTOMER-HSA-1474228
Defective B3GALT6 causes EDSP2 and SEMDJL1REACTOMER-HSA-4420332

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
382436152024The effects of TGF-β1 and IFN-α2b on decorin, decorin isoforms and type I collagen in hypertrophic scar dermal fibroblasts.0
390458982024Decorin attenuates hypertrophic scar fibrosis via TGFβ/Smad signalling.0
382436152024The effects of TGF-β1 and IFN-α2b on decorin, decorin isoforms and type I collagen in hypertrophic scar dermal fibroblasts.0
390458982024Decorin attenuates hypertrophic scar fibrosis via TGFβ/Smad signalling.0
354387732023The aberrant levels of decorin induce damages of human salivary gland epithelial cells and polarization of macrophages.4
364439692023Maternally Expressed Gene 3 Negatively Regulated Decorin to Supresse Angiogenesis, Proliferation and Migration of Endothelial Cells.0
368524402023The levels of peripheral blood TNF-α, Decorin and neutrophils MAPK1 mRNA levels of patients with preeclampsia and their clinical significance.1
369291602023HBx downregulated decorin and decorin-derived peptides inhibit the proliferation and tumorigenicity of hepatocellular carcinoma cells.1
354387732023The aberrant levels of decorin induce damages of human salivary gland epithelial cells and polarization of macrophages.4
364439692023Maternally Expressed Gene 3 Negatively Regulated Decorin to Supresse Angiogenesis, Proliferation and Migration of Endothelial Cells.0
368524402023The levels of peripheral blood TNF-α, Decorin and neutrophils MAPK1 mRNA levels of patients with preeclampsia and their clinical significance.1
369291602023HBx downregulated decorin and decorin-derived peptides inhibit the proliferation and tumorigenicity of hepatocellular carcinoma cells.1
364384792022Decorin promotes decidual M1-like macrophage polarization via mitochondrial dysfunction resulting in recurrent pregnancy loss.6
365238942022Resistance Exercise-Induced Increases in Muscle Myostatin mRNA and Protein Expression Are Subsequently Decreased in Circulation in the Presence of Increased Levels of the Extracellular Matrix Stabilizing Protein Decorin.1
364384792022Decorin promotes decidual M1-like macrophage polarization via mitochondrial dysfunction resulting in recurrent pregnancy loss.6

Citation

Dessen P

DCN (decorin)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40274/dcn-(decorin)