DCTD (dCMP deaminase)

2003-05-01  

Identity

HGNC
DCTD
LOCATION
4q35.1
LOCUSID
1635
ALIAS
-
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 1635
MIM: 607638
HGNC: 2710
Ensembl: ENSG00000129187

Variants:

dbSNP: 1635
ClinVar: 1635
TCGA: ENSG00000129187
COSMIC: DCTD

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000129187ENST00000357067P32321
ENSG00000129187ENST00000438320P32321
ENSG00000129187ENST00000500813D6RD72
ENSG00000129187ENST00000503182D6RBJ9
ENSG00000129187ENST00000503820D6RAR9
ENSG00000129187ENST00000503988D6RAD7
ENSG00000129187ENST00000507543D6R9P0
ENSG00000129187ENST00000507631D6RD72
ENSG00000129187ENST00000508994D6RJA9
ENSG00000129187ENST00000509218D6R9P0
ENSG00000129187ENST00000509757D6R9P0
ENSG00000129187ENST00000510307D6RBN2
ENSG00000129187ENST00000510370P32321
ENSG00000129187ENST00000512766D6R9S0
ENSG00000129187ENST00000513348D6RIG3
ENSG00000129187ENST00000514754D6RC36

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Pyrimidine metabolismKEGGko00240
Pyrimidine metabolismKEGGhsa00240
Metabolic pathwaysKEGGhsa01100
MetabolismREACTOMER-HSA-1430728
Metabolism of nucleotidesREACTOMER-HSA-15869
Pyrimidine metabolismREACTOMER-HSA-73848
Pyrimidine biosynthesisREACTOMER-HSA-500753

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA445218Pancreatic NeoplasmsDiseaseClinicalAnnotationassociatedPD22838950
PA449748gemcitabineChemicalClinicalAnnotationassociatedPD22838950

References

Pubmed IDYearTitleCitations
200287592010Single nucleotide polymorphisms of gemcitabine metabolic genes and pancreatic cancer survival and drug toxicity.37
206654882010Gemcitabine metabolic and transporter gene polymorphisms are associated with drug toxicity and efficacy in patients with locally advanced pancreatic cancer.35
200287592010Single nucleotide polymorphisms of gemcitabine metabolic genes and pancreatic cancer survival and drug toxicity.37
206654882010Gemcitabine metabolic and transporter gene polymorphisms are associated with drug toxicity and efficacy in patients with locally advanced pancreatic cancer.35
176020532007An association between RRM1 haplotype and gemcitabine-induced neutropenia in breast cancer patients.17
176020532007An association between RRM1 haplotype and gemcitabine-induced neutropenia in breast cancer patients.17

Citation

Dessen P

DCTD (dCMP deaminase)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/40275/dctd-(dcmp-deaminase)