UBR5 (ubiquitin protein ligase E3 component n-recognin 5)

2003-06-01  

Identity

HGNC
UBR5
LOCATION
8q22.3
LOCUSID
51366
ALIAS
DD5,EDD,EDD1,HYD
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 51366
MIM: 608413
HGNC: 16806
Ensembl: ENSG00000104517

Variants:

dbSNP: 51366
ClinVar: 51366
TCGA: ENSG00000104517
COSMIC: UBR5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000104517ENST00000220959O95071
ENSG00000104517ENST00000518205E7ET84
ENSG00000104517ENST00000519365H0YAV7
ENSG00000104517ENST00000520539O95071
ENSG00000104517ENST00000520898H0YBB4
ENSG00000104517ENST00000521566E5RFK7
ENSG00000104517ENST00000521922E7EMW7

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Ubiquitin mediated proteolysisKEGGko04120
Ubiquitin mediated proteolysisKEGGhsa04120

References

Pubmed IDYearTitleCitations
376204002024Structural snapshots along K48-linked ubiquitin chain formation by the HECT E3 UBR5.9
378553852024Targeting UBR5 inhibits postsurgical breast cancer lung metastases by inducing CDC73 and p53 mediated apoptosis.2
382804762024Spermatid perinuclear RNA-binding protein promotes UBR5-mediated proteolysis of Dicer to accelerate triple-negative breast cancer progression.0
383311192024The role of UBR5 in tumor proliferation and oncotherapy.0
376204002024Structural snapshots along K48-linked ubiquitin chain formation by the HECT E3 UBR5.9
378553852024Targeting UBR5 inhibits postsurgical breast cancer lung metastases by inducing CDC73 and p53 mediated apoptosis.2
382804762024Spermatid perinuclear RNA-binding protein promotes UBR5-mediated proteolysis of Dicer to accelerate triple-negative breast cancer progression.0
383311192024The role of UBR5 in tumor proliferation and oncotherapy.0
370407672023Structure of the human UBR5 E3 ubiquitin ligase.8
370988082023The role and molecular mechanism of metabolic reprogramming of colorectal cancer by UBR5 through PYK2 regulation of OXPHOS expression study.1
374096332023Cryo-EM structure of the chain-elongating E3 ubiquitin ligase UBR5.6
374788462023UBR5 forms ligand-dependent complexes on chromatin to regulate nuclear hormone receptor stability.8
374788622023Orphan quality control shapes network dynamics and gene expression.7
370407672023Structure of the human UBR5 E3 ubiquitin ligase.8
370988082023The role and molecular mechanism of metabolic reprogramming of colorectal cancer by UBR5 through PYK2 regulation of OXPHOS expression study.1

Citation

Dessen P

UBR5 (ubiquitin protein ligase E3 component n-recognin 5)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/40276/ubr5-(ubiquitin-protein-ligase-e3-component-n-recognin-5)