UBR5 (ubiquitin protein ligase E3 component n-recognin 5)

2003-06-01  

Identity

HGNC
UBR5
LOCATION
8q22.3
LOCUSID
51366
ALIAS
DD5,EDD,EDD1,HYD
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 51366
MIM: 608413
HGNC: 16806
Ensembl: ENSG00000104517

Variants:

dbSNP: 51366
ClinVar: 51366
TCGA: ENSG00000104517
COSMIC: UBR5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000104517ENST00000220959O95071
ENSG00000104517ENST00000518205E7ET84
ENSG00000104517ENST00000519365H0YAV7
ENSG00000104517ENST00000520539O95071
ENSG00000104517ENST00000520898H0YBB4
ENSG00000104517ENST00000521566E5RFK7
ENSG00000104517ENST00000521922E7EMW7

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Ubiquitin mediated proteolysisKEGGko04120
Ubiquitin mediated proteolysisKEGGhsa04120

References

Pubmed IDYearTitleCitations
228846922012TRIP12 and UBR5 suppress spreading of chromatin ubiquitylation at damaged chromosomes.132
120110952002EDD, the human hyperplastic discs protein, has a role in progesterone receptor coactivation and potential involvement in DNA damage response.41
234075522013The E3 ubiquitin ligase UBR5 is recurrently mutated in mantle cell lymphoma.40
211189912011The EDD E3 ubiquitin ligase ubiquitinates and up-regulates beta-catenin.39
180735322007The E3 ubiquitin ligase EDD regulates S-phase and G(2)/M DNA damage checkpoints.32
170747622006EDD mediates DNA damage-induced activation of CHK2.30
233622802013Dyrk2-associated EDD-DDB1-VprBP E3 ligase inhibits telomerase by TERT degradation.25
212282272011Regulation of the human papillomavirus type 18 E6/E6AP ubiquitin ligase complex by the HECT domain-containing protein EDD.23
183498192008The E3 ubiquitin ligase EDD is an adverse prognostic factor for serous epithelial ovarian cancer and modulates cisplatin resistance in vitro.21
213830202011EDD inhibits ATM-mediated phosphorylation of p53.20

Citation

Dessen P

UBR5 (ubiquitin protein ligase E3 component n-recognin 5)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/40276/ubr5-(ubiquitin-protein-ligase-e3-component-n-recognin-5)