Identity
HGNC
LOCATION
8q22.3
LOCUSID
ALIAS
DD5,EDD,EDD1,HYD
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 51366
MIM: 608413
HGNC: 16806
Ensembl: ENSG00000104517
Variants:
dbSNP: 51366
ClinVar: 51366
TCGA: ENSG00000104517
COSMIC: UBR5
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Ubiquitin mediated proteolysis | KEGG | ko04120 |
| Ubiquitin mediated proteolysis | KEGG | hsa04120 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37620400 | 2024 | Structural snapshots along K48-linked ubiquitin chain formation by the HECT E3 UBR5. | 9 |
| 37855385 | 2024 | Targeting UBR5 inhibits postsurgical breast cancer lung metastases by inducing CDC73 and p53 mediated apoptosis. | 2 |
| 38280476 | 2024 | Spermatid perinuclear RNA-binding protein promotes UBR5-mediated proteolysis of Dicer to accelerate triple-negative breast cancer progression. | 0 |
| 38331119 | 2024 | The role of UBR5 in tumor proliferation and oncotherapy. | 0 |
| 37620400 | 2024 | Structural snapshots along K48-linked ubiquitin chain formation by the HECT E3 UBR5. | 9 |
| 37855385 | 2024 | Targeting UBR5 inhibits postsurgical breast cancer lung metastases by inducing CDC73 and p53 mediated apoptosis. | 2 |
| 38280476 | 2024 | Spermatid perinuclear RNA-binding protein promotes UBR5-mediated proteolysis of Dicer to accelerate triple-negative breast cancer progression. | 0 |
| 38331119 | 2024 | The role of UBR5 in tumor proliferation and oncotherapy. | 0 |
| 37040767 | 2023 | Structure of the human UBR5 E3 ubiquitin ligase. | 8 |
| 37098808 | 2023 | The role and molecular mechanism of metabolic reprogramming of colorectal cancer by UBR5 through PYK2 regulation of OXPHOS expression study. | 1 |
| 37409633 | 2023 | Cryo-EM structure of the chain-elongating E3 ubiquitin ligase UBR5. | 6 |
| 37478846 | 2023 | UBR5 forms ligand-dependent complexes on chromatin to regulate nuclear hormone receptor stability. | 8 |
| 37478862 | 2023 | Orphan quality control shapes network dynamics and gene expression. | 7 |
| 37040767 | 2023 | Structure of the human UBR5 E3 ubiquitin ligase. | 8 |
| 37098808 | 2023 | The role and molecular mechanism of metabolic reprogramming of colorectal cancer by UBR5 through PYK2 regulation of OXPHOS expression study. | 1 |
Citation
Dessen P
UBR5 (ubiquitin protein ligase E3 component n-recognin 5)
Atlas Genet Cytogenet Oncol Haematol. 2003-06-01
Online version: http://atlasgeneticsoncology.org/gene/40276/ubr5-(ubiquitin-protein-ligase-e3-component-n-recognin-5)
