Identity
HGNC
LOCATION
1q23.3
LOCUSID
ALIAS
MIG20a,NTRKR3,TKT,TYRO10,WRCN
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 4921
MIM: 191311
HGNC: 2731
Ensembl: ENSG00000162733
Variants:
dbSNP: 4921
ClinVar: 4921
TCGA: ENSG00000162733
COSMIC: DDR2
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Extracellular matrix organization | REACTOME | R-HSA-1474244 |
| Non-integrin membrane-ECM interactions | REACTOME | R-HSA-3000171 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37996700 | 2024 | DDR2-regulated arginase activity in ovarian cancer-associated fibroblasts promotes collagen production and tumor progression. | 4 |
| 38154356 | 2024 | METTL3/YTHDF1 m(6)A axis promotes tumorigenesis by enhancing DDR2 expression in ovarian cancer. | 2 |
| 38538106 | 2024 | DDR2 signaling and mechanosensing orchestrate neuroblastoma cell fate through different transcriptome mechanisms. | 0 |
| 37996700 | 2024 | DDR2-regulated arginase activity in ovarian cancer-associated fibroblasts promotes collagen production and tumor progression. | 4 |
| 38154356 | 2024 | METTL3/YTHDF1 m(6)A axis promotes tumorigenesis by enhancing DDR2 expression in ovarian cancer. | 2 |
| 38538106 | 2024 | DDR2 signaling and mechanosensing orchestrate neuroblastoma cell fate through different transcriptome mechanisms. | 0 |
| 35904852 | 2023 | Special issue "The advance of solid tumor research in China": Discoidin domain receptor 2 promotes colorectal cancer metastasis by regulating epithelial mesenchymal transition via activating AKT signaling. | 0 |
| 36370214 | 2023 | Expression of CILP-2 and DDR2 and ultrastructural changes in the articular cartilage of patients with knee osteoarthritis undergoing total knee arthroplasty: a pilot morphological study. | 1 |
| 35904852 | 2023 | Special issue "The advance of solid tumor research in China": Discoidin domain receptor 2 promotes colorectal cancer metastasis by regulating epithelial mesenchymal transition via activating AKT signaling. | 0 |
| 36370214 | 2023 | Expression of CILP-2 and DDR2 and ultrastructural changes in the articular cartilage of patients with knee osteoarthritis undergoing total knee arthroplasty: a pilot morphological study. | 1 |
| 35711892 | 2022 | Discoidin Domain Receptor 2 Expression as Worse Prognostic Marker in Invasive Breast Cancer. | 3 |
| 35761108 | 2022 | Co-expression of DDR2 and IFITM1 promotes breast cancer cell proliferation, migration and invasion and inhibits apoptosis. | 4 |
| 36713812 | 2022 | DDR2 coordinates EMT and metabolic reprogramming as a shared effector of FOXQ1 and SNAI1. | 0 |
| 35711892 | 2022 | Discoidin Domain Receptor 2 Expression as Worse Prognostic Marker in Invasive Breast Cancer. | 3 |
| 35761108 | 2022 | Co-expression of DDR2 and IFITM1 promotes breast cancer cell proliferation, migration and invasion and inhibits apoptosis. | 4 |
Citation
Dessen P
DDR2 (discoidin domain receptor tyrosine kinase 2)
Atlas Genet Cytogenet Oncol Haematol. 2003-02-01
Online version: http://atlasgeneticsoncology.org/gene/40281/ddr2-(discoidin-domain-receptor-tyrosine-kinase-2)
