DDT (D-dopachrome tautomerase)

2003-05-01  

Identity

HGNC
DDT
LOCATION
22q11.23
LOCUSID
1652
ALIAS
D-DT,DDCT,MIF-2,MIF2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 1652
MIM: 602750
HGNC: 2732
Ensembl: ENSG00000099977

Variants:

dbSNP: 1652
ClinVar: 1652
TCGA: ENSG00000099977
COSMIC: DDT

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000099977ENST00000350608P30046
ENSG00000099977ENST00000350608Q53Y51
ENSG00000099977ENST00000398344P30046
ENSG00000099977ENST00000398344Q53Y51
ENSG00000099977ENST00000403754B5MC82
ENSG00000099977ENST00000428792H7C342
ENSG00000099977ENST00000430101P30046

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
362690192022D-dopachrome tautomerase in cardiovascular and inflammatory diseases-A new kid on the block or just another MIF?6
362690192022D-dopachrome tautomerase in cardiovascular and inflammatory diseases-A new kid on the block or just another MIF?6
334015032021Macrophage Migration Inhibitory Factor (MIF) and Its Homologue d-Dopachrome Tautomerase (DDT) Inversely Correlate with Inflammation in Discoid Lupus Erythematosus.8
340983382021D-dopachrome tautomerase contributes to lung epithelial repair via atypical chemokine receptor 3-dependent Akt signaling.14
342818772021Knockdown of D-dopachrome Tautomerase Inhibits Cell Proliferation in Human HepG2 Cell Line.0
343847842021A structurally preserved allosteric site in the MIF superfamily affects enzymatic activity and CD74 activation in D-dopachrome tautomerase.7
334015032021Macrophage Migration Inhibitory Factor (MIF) and Its Homologue d-Dopachrome Tautomerase (DDT) Inversely Correlate with Inflammation in Discoid Lupus Erythematosus.8
340983382021D-dopachrome tautomerase contributes to lung epithelial repair via atypical chemokine receptor 3-dependent Akt signaling.14
342818772021Knockdown of D-dopachrome Tautomerase Inhibits Cell Proliferation in Human HepG2 Cell Line.0
343847842021A structurally preserved allosteric site in the MIF superfamily affects enzymatic activity and CD74 activation in D-dopachrome tautomerase.7
330468252020Genetic regulation of gene expression of MIF family members in lung tissue.4
330468252020Genetic regulation of gene expression of MIF family members in lung tissue.4
314848222019Cardiomyocyte d-dopachrome tautomerase protects against heart failure.12
314848222019Cardiomyocyte d-dopachrome tautomerase protects against heart failure.12
301407012018Genetic Variant rs755622 Regulates Expression of the Multiple Sclerosis Severity Modifier D-Dopachrome Tautomerase in a Sex-Specific Way.10

Citation

Dessen P

DDT (D-dopachrome tautomerase)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/40282/ddt-(d-dopachrome-tautomerase)