DDX53 (DEAD-box helicase 53)

2003-06-01 Affiliation

Identity

HGNC

DDX53

LOCATION

Xp22.11

LOCUSID

168400

ALIAS

CAGE,CT26

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 168400
HGNC: 20083
Ensembl: ENSG00000184735

Variants:

dbSNP: 168400
ClinVar: 168400
TCGA: ENSG00000184735
COSMIC: DDX53

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000184735	ENST00000327968	Q86TM3

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

References

Pubmed ID	Year	Title	Citations
20531469	2010	Functional impact of global rare copy number variation in autism spectrum disorders.	778
12849980	2003	Promoter hypomethylation of a novel cancer/testis antigen gene CAGE is correlated with its aberrant expression and is seen in premalignant stage of gastric carcinoma.	30
11922625	2002	Identification and characterization of a novel cancer/testis antigen gene CAGE.	29
20534591	2010	Cancer/testis antigen CAGE exerts negative regulation on p53 expression through HDAC2 and confers resistance to anti-cancer drugs.	22
26863629	2016	miR-217 and CAGE form feedback loop and regulates the response to anti-cancer drugs through EGFR and HER2.	7
28152297	2017	DDX53 Promotes Cancer Stem Cell-Like Properties and Autophagy.	7
17341616	2006	DNA hypomethylation of CAGE promotors in squamous cell carcinoma of uterine cervix.	6
18388483	2008	Role of CAGE, a novel cancer/testis antigen, in various cellular processes, including tumorigenesis, cytolytic T lymphocyte induction, and cell motility.	6
26883907	2016	Histone Deacetylase-3/CAGE Axis Targets EGFR Signaling and Regulates the Response to Anti-Cancer Drugs.	6
26912082	2016	miR-30a Regulates the Expression of CAGE and p53 and Regulates the Response to Anti-Cancer Drugs.	6

Citation

Dessen P

DDX53 (DEAD-box helicase 53)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/40291/ddx53-(dead-box-helicase-53)