DGKG (diacylglycerol kinase gamma)

2003-11-01  

Identity

HGNC
DGKG
LOCATION
3q27.2
LOCUSID
1608
ALIAS
DAGK3,DGK-GAMMA
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 1608
MIM: 601854
HGNC: 2853
Ensembl: ENSG00000058866

Variants:

dbSNP: 1608
ClinVar: 1608
TCGA: ENSG00000058866
COSMIC: DGKG

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000058866ENST00000265022P49619
ENSG00000058866ENST00000344484P49619
ENSG00000058866ENST00000382164P49619
ENSG00000058866ENST00000437018H7C0L0

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Glycerolipid metabolismKEGGko00561
Glycerophospholipid metabolismKEGGko00564
Phosphatidylinositol signaling systemKEGGko04070
Glycerolipid metabolismKEGGhsa00561
Glycerophospholipid metabolismKEGGhsa00564
Phosphatidylinositol signaling systemKEGGhsa04070
Metabolic pathwaysKEGGhsa01100
Choline metabolism in cancerKEGGhsa05231
Choline metabolism in cancerKEGGko05231
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Effects of PIP2 hydrolysisREACTOMER-HSA-114508
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907
Phospholipase D signaling pathwayKEGGko04072
Phospholipase D signaling pathwayKEGGhsa04072

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
378380362024Endothelial DGKG promotes tumor angiogenesis and immune evasion in hepatocellular carcinoma.7
378380362024Endothelial DGKG promotes tumor angiogenesis and immune evasion in hepatocellular carcinoma.7
317221162020Characterization of α-synuclein N-terminal domain as a novel cellular phosphatidic acid sensor.5
317221162020Characterization of α-synuclein N-terminal domain as a novel cellular phosphatidic acid sensor.5
303993722018Diacylglycerol kinase γ predicts prognosis and functions as a tumor suppressor by negatively regulating glucose transporter 1 in hepatocellular carcinoma.13
303993722018Diacylglycerol kinase γ predicts prognosis and functions as a tumor suppressor by negatively regulating glucose transporter 1 in hepatocellular carcinoma.13
282184732017Epigenetic silencing of diacylglycerol kinase gamma in colorectal cancer.18
282184732017Epigenetic silencing of diacylglycerol kinase gamma in colorectal cancer.18
244865432014Diacylglycerol kinase γ is a novel anionic phospholipid binding protein with a selective binding preference.5
244865432014Diacylglycerol kinase γ is a novel anionic phospholipid binding protein with a selective binding preference.5
202009782010Replication of previous genome-wide association studies of bone mineral density in premenopausal American women.8
202153972010Implication of genetic variants near NEGR1, SEC16B, TMEM18, ETV5/DGKG, GNPDA2, LIN7C/BDNF, MTCH2, BCDIN3D/FAIM2, SH2B1, FTO, MC4R, and KCTD15 with obesity and type 2 diabetes in 7705 Chinese.58
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
208161952010Analyses of shared genetic factors between asthma and obesity in children.63
202009782010Replication of previous genome-wide association studies of bone mineral density in premenopausal American women.8

Citation

Dessen P

DGKG (diacylglycerol kinase gamma)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/40300/dgkg-(diacylglycerol-kinase-gamma)