Identity
HGNC
LOCATION
17q21.31
LOCUSID
ALIAS
DDX8,Dhr2,HRH1,PRP22,PRPF22
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 1659
MIM: 600396
HGNC: 2749
Ensembl: ENSG00000067596
Variants:
dbSNP: 1659
ClinVar: 1659
TCGA: ENSG00000067596
COSMIC: DHX8
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Spliceosome | KEGG | ko03040 |
| Spliceosome | KEGG | hsa03040 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38282418 | 2024 | Spliceosomal helicases DDX41/SACY-1 and PRP22/MOG-5 both contribute to proofreading against proximal 3' splice site usage. | 0 |
| 38866787 | 2024 | Human gastric cancer progression and stabilization of ATG2B through RNF5 binding facilitated by autophagy-associated CircDHX8. | 0 |
| 38282418 | 2024 | Spliceosomal helicases DDX41/SACY-1 and PRP22/MOG-5 both contribute to proofreading against proximal 3' splice site usage. | 0 |
| 38866787 | 2024 | Human gastric cancer progression and stabilization of ATG2B through RNF5 binding facilitated by autophagy-associated CircDHX8. | 0 |
| 31409651 | 2019 | Structural and functional characterisation of human RNA helicase DHX8 provides insights into the mechanism of RNA-stimulated ADP release. | 7 |
| 31409651 | 2019 | Structural and functional characterisation of human RNA helicase DHX8 provides insights into the mechanism of RNA-stimulated ADP release. | 7 |
| 30191368 | 2018 | A tandem duplication of BRCA1 exons 1-19 through DHX8 exon 2 in four families with hereditary breast and ovarian cancer syndrome. | 7 |
| 30191368 | 2018 | A tandem duplication of BRCA1 exons 1-19 through DHX8 exon 2 in four families with hereditary breast and ovarian cancer syndrome. | 7 |
| 28062851 | 2017 | Human cactin interacts with DHX8 and SRRM2 to assure efficient pre-mRNA splicing and sister chromatid cohesion. | 12 |
| 28062851 | 2017 | Human cactin interacts with DHX8 and SRRM2 to assure efficient pre-mRNA splicing and sister chromatid cohesion. | 12 |
| 23096351 | 2012 | Structural analysis of the C-terminal domain of the spliceosomal helicase Prp22. | 21 |
| 23096351 | 2012 | Structural analysis of the C-terminal domain of the spliceosomal helicase Prp22. | 21 |
| 19724143 | 2009 | Crystallization and preliminary X-ray diffraction analysis of the C-terminal domain of the human spliceosomal DExD/H-box protein hPrp22. | 1 |
| 19724143 | 2009 | Crystallization and preliminary X-ray diffraction analysis of the C-terminal domain of the human spliceosomal DExD/H-box protein hPrp22. | 1 |
Citation
Dessen P
DHX8 (DEAH-box helicase 8)
Atlas Genet Cytogenet Oncol Haematol. 2003-02-01
Online version: http://atlasgeneticsoncology.org/gene/40306/dhx8-(deah-box-helicase-8)
