Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 83932
MIM: 616086
HGNC: 25356
Ensembl: ENSG00000010072
Variants:
dbSNP: 83932
ClinVar: 83932
TCGA: ENSG00000010072
COSMIC: SPRTN
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38086993 | 2024 | SPRTN is involved in hepatocellular carcinoma development through the ER stress response. | 0 |
| 38086993 | 2024 | SPRTN is involved in hepatocellular carcinoma development through the ER stress response. | 0 |
| 36681662 | 2023 | SPRTN patient variants cause global-genome DNA-protein crosslink repair defects. | 9 |
| 36681662 | 2023 | SPRTN patient variants cause global-genome DNA-protein crosslink repair defects. | 9 |
| 35469923 | 2022 | Ubiquitin-directed AAA+ ATPase p97/VCP unfolds stable proteins crosslinked to DNA for proteolysis by SPRTN. | 10 |
| 35469923 | 2022 | Ubiquitin-directed AAA+ ATPase p97/VCP unfolds stable proteins crosslinked to DNA for proteolysis by SPRTN. | 10 |
| 33348378 | 2021 | A ubiquitin switch controls autocatalytic inactivation of the DNA-protein crosslink repair protease SPRTN. | 19 |
| 33558481 | 2021 | SPRTN protease-cleaved MRE11 decreases DNA repair and radiosensitises cancer cells. | 6 |
| 33567341 | 2021 | USP11 mediates repair of DNA-protein cross-links by deubiquitinating SPRTN metalloprotease. | 8 |
| 34551432 | 2021 | Replication-dependent cytotoxicity and Spartan-mediated repair of trapped PARP1-DNA complexes. | 13 |
| 34879279 | 2021 | The protease SPRTN and SUMOylation coordinate DNA-protein crosslink repair to prevent genome instability. | 25 |
| 33348378 | 2021 | A ubiquitin switch controls autocatalytic inactivation of the DNA-protein crosslink repair protease SPRTN. | 19 |
| 33558481 | 2021 | SPRTN protease-cleaved MRE11 decreases DNA repair and radiosensitises cancer cells. | 6 |
| 33567341 | 2021 | USP11 mediates repair of DNA-protein cross-links by deubiquitinating SPRTN metalloprotease. | 8 |
| 34551432 | 2021 | Replication-dependent cytotoxicity and Spartan-mediated repair of trapped PARP1-DNA complexes. | 13 |
Citation
Dessen P
SPRTN (SprT-like N-terminal domain)
Atlas Genet Cytogenet Oncol Haematol. 2004-04-01
Online version: http://atlasgeneticsoncology.org/gene/40315/sprtn-(sprt-like-n-terminal-domain)
