DCAF13 (DDB1 and CUL4 associated factor 13)

2003-12-01  

Identity

HGNC
DCAF13
LOCATION
8q22.3
LOCUSID
25879
ALIAS
GM83,HSPC064,Sof1,WDSOF1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 25879
MIM: 616196
HGNC: 24535
Ensembl: ENSG00000164934

Variants:

dbSNP: 25879
ClinVar: 25879
TCGA: ENSG00000164934
COSMIC: DCAF13

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000164934ENST00000297579A0A087WT20
ENSG00000164934ENST00000519682B3KME9
ENSG00000164934ENST00000521971E5RHM4
ENSG00000164934ENST00000521999A0A087X1F8
ENSG00000164934ENST00000612750Q9NV06
ENSG00000164934ENST00000616836A0A087WT20
ENSG00000164934ENST00000618975Q9NV06

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
rRNA processingREACTOMER-HSA-72312
Major pathway of rRNA processing in the nucleolus and cytosolREACTOMER-HSA-6791226
rRNA modification in the nucleus and cytosolREACTOMER-HSA-6790901
rRNA processing in the nucleus and cytosolREACTOMER-HSA-8868773

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
385784572024CRL4(DCAF13) E3 ubiquitin ligase targets MeCP2 for degradation to prevent DNA hypermethylation and ensure normal transcription in growing oocytes.0
385784572024CRL4(DCAF13) E3 ubiquitin ligase targets MeCP2 for degradation to prevent DNA hypermethylation and ensure normal transcription in growing oocytes.0
367974672023A biallelic variant of DCAF13 implicated in a neuromuscular disorder in humans.4
368843582023A multidimensional pan-cancer analysis of DCAF13 and its protumorigenic effect in lung adenocarcinoma.3
367974672023A biallelic variant of DCAF13 implicated in a neuromuscular disorder in humans.4
368843582023A multidimensional pan-cancer analysis of DCAF13 and its protumorigenic effect in lung adenocarcinoma.3
347756912022Doxorubicin promotes breast cancer cell migration and invasion via DCAF13.12
351788362022DCAF13 promotes breast cancer cell proliferation by ubiquitin inhibiting PERP expression.10
359329792022DCAF13 is essential for the pathogenesis of preeclampsia through its involvement in endometrial decidualization.2
347756912022Doxorubicin promotes breast cancer cell migration and invasion via DCAF13.12
351788362022DCAF13 promotes breast cancer cell proliferation by ubiquitin inhibiting PERP expression.10
359329792022DCAF13 is essential for the pathogenesis of preeclampsia through its involvement in endometrial decidualization.2
333004312020DCAF13 promotes triple-negative breast cancer metastasis by mediating DTX3 mRNA degradation.17
333004312020DCAF13 promotes triple-negative breast cancer metastasis by mediating DTX3 mRNA degradation.17
302830812019Mammalian nucleolar protein DCAF13 is essential for ovarian follicle maintenance and oocyte growth by mediating rRNA processing.33

Citation

Dessen P

DCAF13 (DDB1 and CUL4 associated factor 13)

Atlas Genet Cytogenet Oncol Haematol. 2003-12-01

Online version: http://atlasgeneticsoncology.org/gene/40320/dcaf13